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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

GTP binding protein 1

This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GPCR, CAN, V1a, ACID, OUT
Papers on G-protein
Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection.
Kehrl et al., Bethesda, United States. In J Immunol, Feb 2016
In contrast, AGS3-deficient macrophages had increased mammalian target of rapamycin activity, reduced transcription factor EB activity, and a lower lysosomal mass.
A structure-based consensus scoring scheme for selecting class A aminergic GPCR fragments.
Keseru et al., In J Chem Inf Model, Feb 2016
6 out of the 36 experimentally tested fragments exhibited remarkable antagonist efficacies and 4 showed IC50 values in the low micromolar or submicromolar range in a cell based assay.
A Usual G-Protein-Coupled Receptor in Unusual Membranes.
Liang et al., Tucson, United States. In Angew Chem Int Ed Engl, Feb 2016
We reveal a new allosteric mode of rhodopsin activation incurred by the non-biological membranes: the cationic membrane drives a transition from the inactive MI to the activated MII state in the absence of high [H(+) ] or negative spontaneous curvature.
Loss of neurogenesis in Hydra leads to compensatory regulation of neurogenic and neurotransmission genes in epithelial cells.
Galliot et al., Genève, Switzerland. In Philos Trans R Soc Lond B Biol Sci, Feb 2016
By crossing these results with cell-type-specific transcriptomics, we identified epithelial genes up-regulated upon loss of neurogenesis: transcription factors (Dlx, Dlx1, DMBX1/Manacle, Ets1, Gli3, KLF11, LMX1A, ZNF436, Shox1), epitheliopeptides (Arminins, PW peptide), neurosignalling components (CAMK1D, DDCl2, Inx1), ligand-ion channel receptors (CHRNA1, NaC7), G-Protein Coupled Receptors and FMRFRL.
G-Protein Subunit-α11 Loss-of-Function Mutation, Thr54Met, Causing Familial Hypocalciuric Hypercalcemia Type 2 (FHH2).
Thakker et al., Derry, United Kingdom. In J Bone Miner Res, Feb 2016
Expression of wild-type and the mutant Gα11 in HEK293 cells stably expressing CaSR, demonstrate that the Ca(2+) i responses following stimulation with Ca(2+) o , of the mutant Met54 Gα11 led to a rightward shift of the concentration-response curve with a significantly (p < 0.01) increased mean half-maximal concentration (EC50 ) value of 3.88 mM (95%CI 3.76-4.01
Regulator of G-Protein Signaling 10 Negatively Regulates Cardiac Remodeling by Blocking Mitogen-Activated Protein Kinase-Extracellular Signal-Regulated Protein Kinase 1/2 Signaling.
Yuan et al., Changsha, China. In Hypertension, Jan 2016
We used a genetic approach to study the role of RGS10 in the regulation of pathological cardiac hypertrophy and found that RGS10 can negatively influence pressure overload-induced cardiac remodeling.
How Can Mutations Thermostabilize G-Protein-Coupled Receptors?
Tate et al., Duarte, United States. In Trends Pharmacol Sci, Jan 2016
The data indicate that receptors are stabilized through a combination of factors, including an increase in receptor rigidity, a decrease in collective motion, reduced stress at specific residues, and the presence of ordered water molecules.
Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation.
Sedding et al., Hannover, Germany. In Arterioscler Thromb Vasc Biol, Jan 2016
Mechanistically, inhibition of ERK1/2 phosphorylation and MAPK downstream signaling was shown to be responsible for the anti-proliferative effect of RGS5.
Docosahexaenoic Acid and Its Role in G-Protein-Coupled Receptor 120 Activation in Children Affected by Nonalcoholic Fatty Liver Disease.
Nobili et al., In Endocr Dev, Dec 2015
The anti-inflammatory effects of DHA depend on its ability to alter phospholipid composition of the cell membrane, to disrupt lipid rafts and to hamper the transcriptional activity of nuclear factor-x03BA;B that controls the expression of proinflammatory cytokines.
Spatial and Temporal Aspects of Signaling by G-Protein-Coupled Receptors.
Hofmann et al., Berlin, Germany. In Mol Pharmacol, Sep 2015
While this may be the case in some biologic systems, the example of rhodopsin with its strictly local single-quantum mode of function shows that homogeneity in space and time cannot be a general property of G-protein-coupled systems.
G-Protein-Coupled Receptors: Next Generation Therapeutic Targets in Head and Neck Cancer?
Carey et al., Japan. In Toxins (basel), Aug 2015
In this review, we discuss the roles that galanin receptor type 1 (GALR1) and type 2 (GALR2), tachykinin receptor type 1 (TACR1), and somatostatin receptor type 1 (SST1) play in HNSCC.
Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease.
GAPP study in collaboration with the MCMDM-1VWD study group et al., Sheffield, United Kingdom. In Plos One, 2014
Expression and signalling of the p.T22N PAR4 variant was similar to wild-type, while the TBXA2R variation introduced a cryptic splice site that was predicted to cause premature termination of protein translation.
Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development.
Ojha et al., Abu Dhabi, United Arab Emirates. In Evid Based Complement Alternat Med, 2014
The cannabinoid molecules are derived from Cannabis sativa plant which acts on the cannabinoid receptors types 1 and 2 (CB1 and CB2) which have been explored as potential therapeutic targets for drug discovery and development.
The G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Inhibits Gastric Inflammation Through Antagonizing NF-κB Signaling Pathway.
Wang et al., Beijing, China. In Front Pharmacol, 2014
TGR5 overexpression with ligand treatment inhibited gene expression of interferon-inducible protein 10 (IP-10), TNF-α, and chemoattractant protein-1 (MCP-1) induced by LPS.
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.
Costantini et al., New York City, United States. In Cell, 1997
The product of the Fused locus, Axin, displays similarities to RGS (Regulators of G-Protein Signaling) and Dishevelled proteins.
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