Identification of proteins interacted with bat3 using tandem affinity purification.
Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 28 Mar 2014
Objective To identify the specific protein interactions involved in Bat3-mediated apoptosis.Methods Tandem affinity purification(TAP)was utilized to investigate Bat3-protein interactions,during which full-length human Bat3 fused with Strep2 and FLAG tag as a bait was used to screen the specific protein-protein interactions.The isolated proteins were identified with mass spectrometry.Results TAP studies showed that Ubl4A was identified as a Bat3-binding partner.Further investigation using co-immunoprecipitation confirmed that Bat3 was associated with Ubl4A.Conclusion TAP was successfully established and is suitable for isolating the binding partners of Bat3.
BAG-6, a jack of all trades in health and disease.
Frankfurt am Main, Germany. In Cell Mol Life Sci, Jan 2014
UNLABELLED: BCL2-associated athanogene 6 (BAG-6) (also Bat-3/Scythe) was discovered as a gene product of the major histocompatibility complex class III locus.
Genetic susceptibility to lung cancer and co-morbidities.
Brisbane, Australia. In J Thorac Dis, Oct 2013
Large scale, multi-cohort GWAS of mainly Caucasian, smoking, populations have identified strong associations for lung cancer mapped to chromosomal regions 15q [nicotinic acetylcholine receptor (nAChR) subunits: CHRNA3, CHRNA5], 5p (TERT-CLPTM1L locus) and 6p (BAT3-MSH5).
HLA-dependent tumour development: a role for tumour associate macrophages?
Stockholm, Sweden. In J Transl Med, 2012
BAT3, a positive regulator of MHC class II expression in normal macrophages, seems to be secreted by TAMs, consequently lacking its intracellular function, it looks like acting as an immunosuppressive factor.In conclusion HLA could cover a considerable role in tumour-development orchestrated by tumour-associated macrophages.
Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma.
Boston, United States. In J Clin Oncol, 2010
High-order interactions among reflux, BMI, smoking, and functional polymorphisms in five apoptotic genes (FAS, FASL, IL1B, TP53BP, and BAT3) were investigated by entropy-based multifactor dimensionality reduction (MDR), classification and regression tree (CART), and traditional logistic regression (LR) models.
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
United Kingdom. In Nat Genet, 2008
Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; P(combined) = 4.97 x 10(-10)) and 5p15.33 (rs401681, CLPTM1L; P(combined) = 7.90 x 10(-9)).