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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 05 Dec 2014.

BCL2-associated athanogene 6

G-3, BAT3, Scythe, HLA-B-associated transcript 3
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HLA-B, CAN, Ubiquitin, MHC, HSP70
Papers using G-3 antibodies
The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum.
Supplier
Buratti Emanuele, In PLoS ONE, 2009
... Antibodies against the hemagglutinin (HA) epitope tag were purchased from Roche (3F10), antibodies against BAT3 were obtained from Abcam (ab88292).
Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells.
Supplier
Zimmer Jacques, In PLoS ONE, 2006
... Multhoff, München) and chicken polyclonal anti-BAT3 (ab37751, Abcam, Germany) ...
Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.
Supplier
Ashwell Jonathan D., In PLoS Biology, 2004
... Anti-p97 and anti-BAT3 antibodies were purchased from Fitzgerald Industries and Abcam, respectively ...
Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.
Supplier
Tailleux Ludovic, In PLoS ONE, 1996
... Primers used in the cloning and real-time PCR of BAT3 were designed with Oligoperfect Designer software (Life Technologies, NY) and are described ...
Papers on G-3
Papillomavirus binding factor (PBF) is an intrinsically disordered protein with potential participation in osteosarcoma genesis, in silico evidence.
New
Barrón et al., In Theor Biol Med Model, 03 Jan 2015
The in silico analysis to find out PBF interactions with cellular factors, confirmed the experimentally demonstrated interaction of PBF with two key cellular proteins involved in regulation of cellular apoptosis, 14-3-3beta and Scythe/BAT3 proteins.
mReg2 inhibits nuclear entry of apoptosis-inducing factor in mouse insulinoma cells.
New
Srikant et al., Montréal, Canada. In Growth Factors, 05 Dec 2014
Here we tested the hypothesis that mReg2 may regulate Scythe and/or hsp70 which influence the nuclear import of AIF.
BAT2 and BAT3 polymorphisms as novel genetic risk factors for rejection after HLA-related SCT.
New
Bacchetta et al., Pula, Croatia. In Bone Marrow Transplant, 30 Nov 2014
We identified two single-nucleotide polymorphisms (SNPs) in BAT2 (A/G) and BAT3 (T/C) genes, SNP rs11538264 and SNP rs10484558, both located in the HLA class III region, in strong linkage disequilibrium between each other (R(2)=0.92).
A role for the TIM-3/GAL-9/BAT3 pathway in determining the clinical phenotype of multiple sclerosis.
New
Clerici et al., Milano, Italy. In Faseb J, 30 Nov 2014
T-cell immunoglobulin and mucin domain 3 (Tim-3) ligates galectin-9 (Gal-9); this process, resulting in the inhibition of Th1 responses and in the apoptosis of antigen-specific cells, is hampered by binding of the molecular adaptor human leukocyte antigen B (HLA-B)-associated transcript 3 (Bat3) to the intracellular tail of Tim-3.
BAG-6, a jack of all trades in health and disease.
Review
New
Koch et al., Frankfurt am Main, Germany. In Cell Mol Life Sci, May 2014
BCL2-associated athanogene 6 (BAG-6) (also Bat-3/Scythe) was discovered as a gene product of the major histocompatibility complex class III locus.
Effect of HLA-B-associated Transcript 3 Polymorphisms on Lung Cancer Risk: A Meta-Analysis.
New
Jin et al., Lishui, China. In Med Sci Monit, Dec 2013
Background The association between the HLA-B-associated transcript 3 polymorphisms and lung cancer risk is a subject of debate.
Genetic susceptibility to lung cancer and co-morbidities.
Review
New
Fong et al., Brisbane, Australia. In J Thorac Dis, Oct 2013
Large scale, multi-cohort GWAS of mainly Caucasian, smoking, populations have identified strong associations for lung cancer mapped to chromosomal regions 15q [nicotinic acetylcholine receptor (nAChR) subunits: CHRNA3, CHRNA5], 5p (TERT-CLPTM1L locus) and 6p (BAT3-MSH5).
Bag6/Bat3/Scythe: a novel chaperone activity with diverse regulatory functions in protein biogenesis and degradation.
Review
New
Ye et al., Bethesda, United States. In Bioessays, Apr 2013
The key component, Bag6/Bat3/Scythe, can effectively shield long hydrophobic segments exposed on the surface of a polypeptide, preventing aggregation or inappropriate interactions before a triaging decision is made.
BAG6/BAT3: emerging roles in quality control for nascent polypeptides.
Review
New
Yokota et al., Tokyo, Japan. In J Biochem, Feb 2013
BAG6 (also known as BAT3/Scythe) is a ubiquitin-like protein that is thought to participate in a variety of seemingly unrelated physiological and pathological processes, such as apoptosis, antigen presentation and the T-cell response.
HLA-dependent tumour development: a role for tumour associate macrophages?
Review
Masucci et al., Stockholm, Sweden. In J Transl Med, 2012
BAT3, a positive regulator of MHC class II expression in normal macrophages, seems to be secreted by TAMs, consequently lacking its intracellular function, it looks like acting as an immunosuppressive factor.In conclusion HLA could cover a considerable role in tumour-development orchestrated by tumour-associated macrophages.
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.
Impact
GeneRIF
Kuchroo et al., Boston, United States. In Nat Med, 2012
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion.
Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases.
GeneRIF
Wang et al., Durham, United States. In Embo J, 2012
These findings identify a novel role for Bat3 in regulating DOT1L function, which plays a critical role in DNA damage response.
Scythe cleavage during Fas (APO-1)-and staurosporine-mediated apoptosis.
GeneRIF
Fadeel et al., Stockholm, Sweden. In Febs Lett, 2012
Data show that cleavage of Scythe by caspase-3 occurs after activation of both the extrinsic (i.e. Fas/APO-1-mediated) and the intrinsic (i.e. staurosporine-induced) apoptosis pathway.
A novel BAT3 sequence generated by alternative RNA splicing of exon 11B displays cell type-specific expression and impacts on subcellular localization.
GeneRIF
Koch et al., Bonn, Germany. In Plos One, 2011
Cell type-specific subcellular expression of BAT3 suggests distinct functions in the cytosol and in the nucleus.
BAT3 guides misfolded glycoproteins out of the endoplasmic reticulum.
GeneRIF
Ploegh et al., Cambridge, United States. In Plos One, 2010
BAT3, a cytosolic chaperone, is recruited to the site of dislocation through its interaction with Derlin2.
A ribosome-associating factor chaperones tail-anchored membrane proteins.
Impact
Hegde et al., Bethesda, United States. In Nature, 2010
Here we identify a conserved three-protein complex composed of Bat3, TRC35 and Ubl4A that facilitates TA protein capture by TRC40.
Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma.
Impact
Christiani et al., Boston, United States. In J Clin Oncol, 2010
High-order interactions among reflux, BMI, smoking, and functional polymorphisms in five apoptotic genes (FAS, FASL, IL1B, TP53BP, and BAT3) were investigated by entropy-based multifactor dimensionality reduction (MDR), classification and regression tree (CART), and traditional logistic regression (LR) models.
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
Impact
Houlston et al., United Kingdom. In Nat Genet, 2008
Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; P(combined) = 4.97 x 10(-10)) and 5p15.33 (rs401681, CLPTM1L; P(combined) = 7.90 x 10(-9)).
Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells.
Impact
GeneRIF
Engert et al., Köln, Germany. In Immunity, 2007
HLA-B-associated transcript 3 (BAT3) was released from tumor cells, bound directly to NKp30, and engaged NKp30 on NK cells. BAT3 triggered NKp30-mediated cytotoxicity and was necessary for tumor rejection in a multiple myeloma model.
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