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RNA binding motif protein 5

G-15, H37, 1-Acylglycerol-3-Phosphate O-Acyltransferase, RBM5
This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, OUT, POLYMERASE
Papers using G-15 antibodies
Tuberculosis associated with infliximab, a tumor necrosis factor α-neutralizing agent
Supplier
Paleolog Ewa M et al., In Arthritis Research & Therapy, 2000
... H37 Ra (Difco Becton Dickinson, Cowley, Oxford, UK) ...
Papers on G-15
Co- and post-transcriptional regulation of Rbm5 and Rbm10 in mouse cells as evidenced by tissue-specific, developmental and disease-associated variation of splice variant and protein expression levels.
New
Sutherland et al., Skövde, Sweden. In Gene, Feb 2016
BACKGROUND: Expression and function of the two RNA binding proteins and regulators of alternative splicing, RBM5 and RBM10, have largely been studied in human tissue and cell lines.
RNA-binding motif protein 5 inhibits the proliferation of cigarette smoke-transformed BEAS-2B cells through cell cycle arrest and apoptosis.
New
Zhang et al., Changchun, China. In Oncol Rep, Feb 2016
Recent studies have also indicated that RNA-binding motif protein 5 (RBM5) can modulate apoptosis and suppress tumor growth.
Nuclear Magnetic Resonance Structure of a Novel Globular Domain in RBM10 Containing OCRE, the Octamer Repeat Sequence Motif.
New
Wüthrich et al., Los Angeles, United States. In Structure, Feb 2016
The OCtamer REpeat (OCRE) has been annotated as a 42-residue sequence motif with 12 tyrosine residues in the spliceosome trans-regulatory elements RBM5 and RBM10 (RBM [RNA-binding motif]), which are known to regulate alternative splicing of Fas and Bcl-x pre-mRNA transcripts.
Synthesis, antiviral activity, 3D-QSAR, and interaction mechanisms study of novel malonate derivatives containing quinazolin-4(3H)-one moiety.
New
Song et al., Guiyang, China. In Bioorg Med Chem Lett, Feb 2016
Notably, compounds g15, g16, g17, and g18 exhibited excellent curative activities in vivo against CMV, with 50% effective concentration (EC50) values of 208.36, 153.78, 181.47, and 164.72μg/mL, respectively, which were better than that of Ningnanmycin (256.35μg/mL) and Ribavirin (523.34μg/mL).
Post-transcriptional regulation of Rbm5 expression in undifferentiated H9c2 myoblasts.
New
Sutherland et al., Greater Sudbury, Canada. In In Vitro Cell Dev Biol Anim, Jan 2016
UNASSIGNED: We previously examined the expression of Rbm5 during myoblast differentiation and found significantly more protein in the early stages of skeletal myoblast differentiation than during the later stages.
Conserved histidine residues at the ferroxidase center of the Campylobacter jejuni Dps protein are not strictly required for metal binding and oxidation.
New
Huergo et al., Brazil. In Microbiology, Dec 2015
In this study, we analyzed the role of two conserved histidine residues (H25 and H37) located at the ferroxidase center of the Campylobacter jejuni Dps protein by replacing them with glycine residues.
Different origin of adipogenic stem cells influences the response to antiretroviral drugs.
Review
New
Cossarizza et al., Modena, Italy. In Exp Cell Res, Nov 2015
CCAAT/enhancer-binding protein alpha (CEBPα) and peroxisome proliferator-activated receptor gamma (PPARγ), and in adipocyte functions, i.e. fatty acid synthase (FASN), fatty acid binding protein-4 (FABP4), perilipin-1 (PLIN1) and 1-acylglycerol-3-phosphate O-acyltransferase-2 (AGPAT2), were quantified by real time PCR.
An overview to understand the role of PE_PGRS family proteins in Mycobacterium tuberculosis H37 Rv and their potential as new drug targets.
Review
New
Meena, Delhi, India. In Biotechnol Appl Biochem, Mar 2015
Tuberculosis has long been the scourge of humanity, claiming millions of lives.
Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes against Mycobacterium tuberculosis.
Yamgar et al., Mumbai, India. In Bioinorg Chem Appl, 2014
A new series of quinoline hydrazone derivatives and their metal complexes have been synthesized and their biological properties have been evaluated against Mycobacterium tuberculosis (H37 RV strain).
Identification of mutant genes with high-frequency, high-risk, and high-expression in lung adenocarcinoma.
Mei et al., Shanghai, China. In Thorac Cancer, 2014
CONCLUSION: For the mutant genes with high-frequency-risk-expression, CTNND1, DUSP6, MDH1 and RBM5 were identified.
Generation of membrane diversity by lysophospholipid acyltransferases.
Review
Shimizu et al., Tokyo, Japan. In J Biochem, 2013
Recently, several laboratories, including ours, isolated LPLATs that function in the Lands' cycle from the 1-acylglycerol-3-phosphate O-acyltransferase family and the membrane bound O-acyltransferases family.
Solution structure of the second RRM domain of RBM5 and its unusual binding characters for different RNA targets.
GeneRIF
Shi et al., Hefei, China. In Biochemistry, 2012
NMR data analysis of RBM5 RRM2 reveals several features of protein-RNA interfaces. The most striking observation is the presence of two preferred target RNA sequences, the sequences [5'-(CUCUUC)-3'] and [5'-(GAGAAG)-3'].
Tumor suppressor RBM5 directly interacts with the DExD/H-box protein DHX15 and stimulates its helicase activity.
GeneRIF
Li et al., Beijing, China. In Febs Lett, 2012
Data suggest that G-patch domain of RBM5 is indispensable for its ability to interact with DHX15; RBM5 stimulates helicase activity of DHX15 in a G-patch domain-dependent manner.
p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.
GeneRIF
Brachmann et al., Sapporo, Japan. In Int J Cancer, 2011
p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.
RBM5/H37 tumor suppressor, located at the lung cancer hot spot 3p21.3, alters expression of genes involved in metastasis.
GeneRIF
Slamon et al., Los Angeles, United States. In Lung Cancer, 2010
alters expression of genes involved in metastasis
RBM5 as a putative tumor suppressor gene for lung cancer.
Review
Robinson et al., Greater Sudbury, Canada. In J Thorac Oncol, 2010
RBM5 is one member of a group of structurally related genes that includes RBM6 and RBM10.
Identification and characterisation of a novel antisense non-coding RNA from the RBM5 gene locus.
GeneRIF
Sutherland et al., Greater Sudbury, Canada. In Gene, 2009
LUST is a novel, functional, non-coding RNA that plays a role in determining the apoptotic fate of a cell by regulating the expression of RBM5 splice variants.
Recent progress on acyl CoA: lysophospholipid acyltransferase research.
Review
Shimizu et al., Tokyo, Japan. In J Lipid Res, 2009
Recently, several laboratories, including ours, have identified enzymes working in the Lands' cycle from the 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) family, and also from the membrane bound O-acyltransferases (MBOAT) family.
The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation.
Impact
Helmann et al., Ithaca, United States. In Nature, 2006
Protein oxidation, catalysed by a bound ferrous ion, leads to the rapid and direct incorporation of one oxygen atom into histidine 37 (H37) or H91, two of the residues that coordinate the bound Fe2+.
AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34.
Impact
Garg et al., Dallas, United States. In Nat Genet, 2002
We report several different mutations of the gene (AGPAT2) encoding 1-acylglycerol-3-phosphate O-acyltransferase 2 in 20 affected individuals from 11 pedigrees of diverse ethnicities showing linkage to chromosome 9q34.
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