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GRINL1A complex locus 1

G up, GRINL1A, Gcom, Gcom1
This locus represents naturally occurring readthrough transcription between the neighboring MYZAP (myocardial zonula adherens protein) and POLR2M (polymerase (RNA) II (DNA directed) polypeptide M) genes on chromosome 15. Alternate splicing results in two readthrough transcript variants that encode different isoforms. One of the readthrough variants encodes a fusion protein that shares sequence identity with each individual gene product. The other variant encodes a protein that shares sequence identity with the upstream gene product but its C-terminal region is distinct due to frameshifts relative to the downstream gene. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: CAN, HLA-G, ACID, POLYMERASE, V1a
Papers on G up
Sub-inhibitory concentrations of penicillin G induce biofilm formation by field isolates of Actinobacillus pleuropneumoniae.
New
Jacques et al., Saint-Hyacinthe, Canada. In Vet Microbiol, Oct 2015
Furthermore, sub-MIC of penicillin G up-regulated the expression of pgaA, which encodes a protein involved in PGA synthesis, and the genes encoding the envelope-stress sensing two-component regulatory system CpxRA.
Primary Central Nervous System (CNS) Lymphoma B Cell Receptors Recognize CNS Proteins.
New
Deckert et al., Köln, Germany. In J Immunol, Sep 2015
Interestingly, proteins (GRINL1A, centaurin-α, BAIAP2) recognized by the recAbs are physiologically expressed by CNS neurons.
TGF-β induces HLA-G expression through inhibiting miR-152 in gastric cancer cells.
Qu et al., Jinan, China. In J Biomed Sci, 2014
RESULTS: TGF-β and HLA-G levels were analyzed in blood samples from twenty GC patients with ELISA assays, while TGF-β showed directly proportional to HLA-G levels in GC patients, and TGF-β induced HLA-G up-regulation was also confirmed in GC cell lines.
A novel aqueous parenteral formulation of docetaxel using prodrugs.
Cho et al., Taejŏn, South Korea. In Int J Pharm, 2014
It was observed that the novel mixture of 15% PEG 400, 2.5% Tween 80 and 20% hydroxypropyl-β-cyclodextrin significantly increased the solubility of DTX-G up to 5.7 mg/mL.
Circulating MicroRNAs as potential biomarkers for alcoholic steatohepatitis.
Li et al., Hangzhou, China. In Liver Int, 2013
Besides, Ccdc117, Gcom1, Zmynd11 and Zfp423 were found at top list as under common regulation of maximum miRNAs.
Biologically relevant doses of mixed aflatoxins B and G up-regulate MyD88, TLR2, TLR4 and CD14 transcripts in human PBMCs.
Saleh-moghaddam et al., Mashhad, Iran. In Immunopharmacol Immunotoxicol, 2013
CONTEXT: Aflatoxins (AFs) are highly hazardous carcinogenic mycotoxins originated from very common fungi present in the environment.
RGD capsid modification enhances mucosal protective immunity of a non-human primate adenovirus vector expressing Pseudomonas aeruginosa OprF.
Worgall et al., New York City, United States. In Clin Exp Immunol, 2013
Intratracheal immunization of mice with either AdC7OprF.RGD or AdC7OprF induced robust serum levels of anti-OprF immunoglobulin (Ig)G up to 12 weeks that were higher compared to immunization with the human vectors Ad5OprF or Ad5OprF.RGD.
The human leukocyte antigen G promotes trophoblast fusion and β-hCG production through the Erk1/2 pathway in human choriocarcinoma cell lines.
Yao et al., Tianjin, China. In Biochem Biophys Res Commun, 2013
HLA-G up-regulates β-hCG production in human choriocarcinoma cells because HLA-G knockdown in JEG-3 cells induces a dramatic decrease in β-hCG compared with control cells.
Functional association of Gdown1 with RNA polymerase II poised on human genes.
GeneRIF
Price et al., Iowa City, United States. In Mol Cell, 2012
Gdown1 stabilizes poised polymerases while maintaining their responsiveness to P-TEFb.
Transcriptional regulation by Pol II(G) involving mediator and competitive interactions of Gdown1 and TFIIF with Pol II.
GeneRIF
Roeder et al., New York City, United States. In Mol Cell, 2012
Gdown1 competes with TFIIF for binding to the RPB1 and RPB5 subunits of Pol II, thereby inhibiting an essential function of TFIIF in preinitiation complex assembly.
Bone marrow-derived mesenchymal stem cells repaired but did not prevent gentamicin-induced acute kidney injury through paracrine effects in rats.
Schor et al., São Paulo, Brazil. In Plos One, 2011
Animals received daily injections of G up to 20 days.
Soluble HLA-G dampens CD94/NKG2A expression and function and differentially modulates chemotaxis and cytokine and chemokine secretion in CD56bright and CD56dim NK cells.
Pistoia et al., Genova, Italy. In Blood, 2011
sHLA-G up-regulated secretion of (1) CCL22 in CD56bright and CD56dim and (2) CCL2, CCL8, and CXCL2-CXCL3 in CD56dim PB NK cells.
Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B.
Greenblatt et al., Toronto, Canada. In Transcription, 2011
Here, we identify by affinity purification and mass spectrometry three previously uncharacterized human CTD-interaction domain (CID)-containing proteins, RPRD1A, RPRD1B and RPRD2, which co-purify with RNAP II and three other RNAP II-associated proteins, RPAP2, GRINL1A and RECQL5, but not with the Mediator complex.
Identification of human UGT isoforms responsible for glucuronidation of efavirenz and its three hydroxy metabolites.
Liu et al., Puch'ŏn, South Korea. In Xenobiotica, 2011
Furthermore, fluconazole, a known UGT2B7 inhibitor, potently inhibited the formation of EFV-G up to 80%.
Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration.
Zhang et al., Hong Kong, Hong Kong. In Embo J, 2011
Structural studies reveal that the binding of a β hairpin from GRINL1A converts ZO-1 ZU5 into a complete ZU5-fold.
Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A.
GeneRIF
Bruix et al., Madrid, Spain. In Febs J, 2010
Data identify GRINL1A as a membrane-associated DYNLL1 binding partner and suggest that additional DYNLL1-binding partners are present near this glutamate channel homolog.
Myozap, a novel intercalated disc protein, activates serum response factor-dependent signaling and is required to maintain cardiac function in vivo.
GeneRIF
Frey et al., Kiel, Germany. In Circ Res, 2010
Reveal myozap as a previously unrecognized component of a Rho-dependent signaling pathway that links the intercalated disc to cardiac gene regulation.
The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes.
GeneRIF
Rowen et al., Philadelphia, United States. In Genomics, 2004
genetic and transcriptional organization of gene
Mammalian Ogg1/Mmh gene plays a major role in repair of the 8-hydroxyguanine lesion in DNA.
Review
Nishimura, Tsukuba, Japan. In Prog Nucleic Acid Res Mol Biol, 2000
A further increase of 8-OH-G up to 7-fold was observed in 14-week-old animals.
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