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Lysophosphatidic acid receptor 2

G protein-coupled receptor, LPA2
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, LpA-I, GPCR, GPCR, CAN
Papers on G protein-coupled receptor
The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules.
Gomeza et al., Bonn, Germany. In J Biol Chem, Feb 2016
GPR17, in particular, is an orphan G protein-coupled receptor that has been identified as oligodendroglial maturation inhibitor because its stimulation arrests primary mouse oligodendrocytes at a less differentiated stage.
G Protein-Coupled Receptor Biased Agonism.
Rockman et al., Durham, United States. In J Cardiovasc Pharmacol, Feb 2016
UNASSIGNED: G protein-coupled receptors (GPCR) are the largest family of targets for current therapeutics.
Feedback Regulation of G Protein-Coupled Receptor Signaling by GRKs and Arrestins.
Daaka et al., Durham, United States. In Semin Cell Dev Biol, Feb 2016
UNASSIGNED: GPCR are ubiquitous in mammalian cells and present intricate mechanisms for cellular signaling and communication.
Design of Next-Generation G Protein-Coupled Receptor Drugs: Linking Novel Pharmacology and In Vivo Animal Models.
Tobin et al., Leicester, United Kingdom. In Annu Rev Pharmacol Toxicol, Feb 2016
Despite the fact that G protein-coupled receptors (GPCRs) are the most successful drug targets in history, this supergene family of cell surface receptors has yet to be fully exploited as targets in the treatment of human disease.
G Protein-Coupled Receptor Heteromers.
Devi et al., France. In Annu Rev Pharmacol Toxicol, Feb 2016
G protein-coupled receptors (GPCRs) compose one of the largest families of membrane proteins involved in intracellular signaling.
Adropin Acts in Brain to Inhibit Water Drinking: Potential Interaction with the Orphan G Protein-Coupled Receptor, GPR19.
Samson et al., Saint-Louis, Senegal. In Am J Physiol Regul Integr Comp Physiol, Feb 2016
We describe a central nervous system action of adropin to inhibit water drinking and identify a potential adropin receptor, the orphan G protein-coupled receptor, GPR19.
NT-3 protein levels are enhanced in the hippocampus of PRG1-deficient mice but remain unchanged in PRG1/LPA2 double mutants.
Roskoden et al., Magdeburg, Germany. In Neurosci Lett, Jan 2016
Since PRG1 deficiency leads to increased neuronal excitability and higher hippocampal network activity, which may well influence neurotrophin levels, we further assessed PRG1 deficient mice on an LPA2-receptor (LPA2R) deficient background, reported to normalize hippocampal over-excitability in PRG1(-/-) mice.
G Protein-Coupled Receptor Signaling Networks from a Systems Perspective.
Bruggeman et al., Dublin, Ireland. In Mol Pharmacol, Sep 2015
The signal-transduction network of a mammalian cell integrates internal and external cues to initiate adaptive responses.
A Molecular Pharmacologist's Guide to G Protein-Coupled Receptor Crystallography.
Deupi et al., Switzerland. In Mol Pharmacol, Sep 2015
G protein-coupled receptor (GPCR) structural biology has progressed dramatically in the last decade.
The evolving impact of g protein-coupled receptor kinases in cardiac health and disease.
Koch et al., Suwŏn, South Korea. In Physiol Rev, Apr 2015
G protein-coupled receptors (GPCRs) are important regulators of various cellular functions via activation of intracellular signaling events.
The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of Neutrophils.
Jin et al., Rockville, United States. In J Immunol Res, 2014
Chemotaxis is mediated by the G protein-coupled receptor (GPCR) signaling pathway.
Expressions of lysophosphatidic acid receptors in the development of human ovarian carcinoma.
Tang et al., Guangzhou, China. In Int J Clin Exp Med, 2014
The value of LPA2 and LPA3 in discriminating OC was confirmed by receiver-operator characteristic (ROC) curves analysis.
Overexpression of Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5 (LGR5) Represents a Typical Wnt/β-Catenin Pathway-Activated Hepatocellular Carcinoma.
Sakamoto et al., Tokyo, Japan. In Liver Cancer, 2014
We previously identified overexpression of the leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), also known as GPR49, in HCC with β-catenin mutations.
Lysophosphatidic acid receptor 2/3-mediated IL-8-dependent angiogenesis in cervical cancer cells.
Lin et al., Taipei, Taiwan. In Int J Cancer, 2012
found that LPA receptor 2/3-mediated IL-8 expression occurs through Gi/PI3K/AKT, Gi/PKC and IkappaB/NF-kappaB signaling
Lpa2 is a negative regulator of both dendritic cell activation and murine models of allergic lung inflammation.
Georas et al., Rochester, United States. In J Immunol, 2012
these findings identify LPA acting via lpa2 as a novel negative regulatory pathway that inhibits DC activation and allergic airway inflammation.
Modulation of LPA receptor expression in the human brain following neurotrauma.
Pébay et al., Melbourne, Australia. In Cell Mol Neurobiol, 2011
This work shows for the first time that key components of the LPA pathway are modulated following traumatic brain injuries in humans.
MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.
Yun et al., Atlanta, United States. In Gastroenterology, 2011
MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.
Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells.
Tsujiuchi et al., Ōsaka, Japan. In Virchows Arch, 2010
LPA2 gene mutation may play some role in the pathogenesis of colon cancer.
Milestones in the Activation of a G Protein-Coupled Receptor. Insights from Molecular-Dynamics Simulations into the Human Cholecystokinin Receptor-1.
Chipot, Vandœuvre-lès-Nancy, France. In J Chem Theory Comput, 2009
Activation of G protein-coupled receptors (GPCRs) obeys an allosteric mechanism triggered by ligand binding.
Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity.
Leurs et al., Amsterdam, Netherlands. In Annu Rev Pharmacol Toxicol, 2006
G protein-coupled receptors (GPCRs) respond to a chemically diverse plethora of signal transduction molecules.
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