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Frizzled family receptor 8

FZD8, Frizzled 8, Fz8
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on FZD8
Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche.
Impact
GeneRIF
Li et al., Kansas City, United States. In Cell, 2012
Study shows Flamingo (Fmi) and Frizzled (Fz) 8, members of noncanonical Wnt signaling, both express in and functionally maintain quiescent long-term hematopoietic stem cells.
Structural basis of Wnt recognition by Frizzled.
Impact
GeneRIF
Garcia et al., Stanford, United States. In Science, 2012
study presents the structure of Xenopus Wnt8 (XWnt8) in complex with the mouse Fz8-cysteine-rich domain to a resolution of 3.25 A
Regulation of retinal progenitor expansion by Frizzled receptors: implications for microphthalmia and retinal coloboma.
GeneRIF
Swaroop et al., Bethesda, United States. In Hum Mol Genet, 2012
studies suggest a dose-dependent regulation of signaling by Fz5 and Fz8 in optic fissure/disc formation and progenitor expansion
Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8.
GeneRIF
Musso et al., Rennes, France. In Plos One, 2011
Soluble FZC18 and Wnt3a physically interact in a cell-free system and soluble FZC18 binds the frizzled 1 and 8 receptors.
Genetic mosaic analysis reveals a major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney.
GeneRIF
Nathans et al., Baltimore, United States. In Development, 2011
A major role for frizzled 4 and frizzled 8 in controlling ureteric growth in the developing kidney.
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