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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Frizzled family receptor 7

FZD7, Frizzled-7, Fz7, FzE3
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Frizzled, CAN, Frizzled-2, Wnt5a, FZD6
Papers on FZD7
MicroRNA-27b suppresses Helicobacter pylori-induced gastric tumorigenesis through negatively regulating Frizzled7.
New
Xu et al., Xi'an, China. In Oncol Rep, Feb 2016
Frizzled7 (FZD7) is an important co-receptor in the WNT signaling pathway.
MicroRNA-613 represses prostate cancer cell proliferation and invasion through targeting Frizzled7.
New
Xing et al., Xi'an, China. In Biochem Biophys Res Commun, Feb 2016
Frizzled7 (Fzd7), the most important receptor of the Wnt signaling pathway, is extensively involved in cancer development and progression.
Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.
New
Henry et al., Urbana, United States. In Exp Eye Res, Feb 2016
Numerous frizzled receptors (fzd1, fzd2, fzd3, fzd4, fzd6, fzd7, fzd8, and fzd10) and wnt ligands (wnt2b.a,
Wnt inhibition is dysregulated in gliomas and its re-establishment inhibits proliferation and tumor sphere formation.
New
Vik-Mo et al., Oslo, Norway. In Exp Cell Res, Feb 2016
This identified a six-gene Wnt signature present in all nine primary GSC cultures, and the combined expression of three of these genes (SFRP1, SFRP4 and FZD7) reduced median survival of glioma patients from 38 to 17 months.
FZD7 regulates BMSCs-mediated protection of CML cells.
New
Ji et al., China. In Oncotarget, Jan 2016
In this study, we found that BMSCs increased the expression of FZD7 and activated Wnt/β-catenin signaling pathway in CML cells.
High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells.
New
Lee et al., Taiwan. In Sci Rep, Dec 2015
The top five upregulated genes were SNAI2, FGFBP1, VIM, SPARC (osteonectin), and SERPINE1, while the downregulated genes included OCLN, TJP1 (ZO-1), FZD7, CDH1 (E-cadherin), and LAMA5.
Overexpression and knockout of miR-126 both promote leukemogenesis.
New
Chen et al., Chicago, United States. In Blood, Nov 2015
Mechanistically, miR-126 overexpression activates genes that are highly expressed in LSCs/LICs and/or primitive hematopoietic stem/progenitor cells, likely through targeting ERRFI1 and SPRED1, whereas miR-126 knockout activates genes that are highly expressed in committed, more differentiated hematopoietic progenitor cells, presumably through inducing FZD7 expression.
[Shenshuai Yingyang capsule ameliorates muscle atrophy in rats with chronic renal failure: role of Wnt7a-Akt/mTOR signal pathway].
New
Wei et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, Aug 2015
Protein synthesis in the soleus muscle was investigated by (14)C-phenylalanine experiment, and the expression of Wnt7a, frizzled-7, phospho-Akt, phospho-mTOR and GAPDH were detected with Western blotting.
Rhesus monkey model of liver disease reflecting clinical disease progression and hepatic gene expression analysis.
Si et al., Kunming, China. In Sci Rep, 2014
The up-regulation of expression of hepatic genes related to liver steatosis (CPT1A, FASN, LEPR, RXRA, IGFBP1, PPARGC1A and SLC2A4) was detected in our rhesus model, as was the down-regulation of such genes (CYP7A1, HMGCR, GCK and PNPLA3) and the up-regulation of expression of hepatic genes related to liver cancer (E2F1, OPCML, FZD7, IGFBP1 and LEF1).
[Ways to personalized medicine for gastric cancer].
Review
Röcken, Kiel, Germany. In Pathologe, 2013
AT1R, AT2R, CXCR4, FZD7, LGR4, LGR5, LGR6).
[Molecular pathology of gastric cancer].
Review
Warneke et al., Kiel, Germany. In Pathologe, 2012
ADAM17, CD133, FZD7, LGR5) and correlate with patient prognosis.
Wnt-11 and Fz7 reduce cell adhesion in convergent extension by sequestration of PAPC and C-cadherin.
GeneRIF
Wedlich et al., Karlsruhe, Germany. In J Cell Biol, 2012
Because paraxial protocadherin and C-cadherin do not directly interact nor form a joint complex with Fz7, Wnt-11 triggers the formation of two distinct complexes that act in parallel to reduce cell adhesion by hampering clustering of C-cadherin.
Frizzled7 as an emerging target for cancer therapy.
Review
Li et al., Birmingham, United States. In Cell Signal, 2012
Recent studies indicated that, among the Fzd family, Fzd7 is the Wnt receptor most commonly upregulated in a variety of cancers including colorectal cancer, hepatocellular carcinoma and triple negative breast cancer.
Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle.
Impact
GeneRIF
Rudnicki et al., Ottawa, Canada. In Nat Cell Biol, 2012
Data show that the Fzd7 receptor complex was associated with Galpha(s) and PI(3)K and these components were required for Wnt7a to activate the Akt/mTOR growth pathway in myotubes.
The Wnt/β-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer.
Review
Li et al., Birmingham, United States. In J Cell Biochem, 2012
Recent studies indicate that Wnt/β-catenin signaling is particularly activated in TNBC, such that the Wnt receptor frizzled-7 (FZD7) and the Wnt co-receptor LRP6 were found to be up regulated in TNBC.
FZD7 has a critical role in cell proliferation in triple negative breast cancer.
GeneRIF
Yen et al., Duarte, United States. In Oncogene, 2011
Our findings suggest that FZD7-involved canonical Wnt signaling pathway is essential for tumorigenesis of TNBC.
Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin.
GeneRIF
So et al., Stanford, United States. In Mol Cancer, 2010
Extracellular domain of FZD7 (sFZD7) was tested for its functional activity to interact with Wnt3, its ability to inhibit Wnt3-mediated signaling.
Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization.
GeneRIF
Minami et al., Kōbe, Japan. In Mol Cell Biol, 2010
Ror2/Fz7 receptor complex plays an important role in the Wnt5a/Rac1/AP-1 pathway by regulating the polymerization of Dvl.
WNT signaling in stem cell biology and regenerative medicine.
Review
Katoh, Tokyo, Japan. In Curr Drug Targets, 2008
FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, FZD10, LRP5, LRP6, and ROR2 are transmembrane receptors transducing WNT signals based on ligand-dependent preferentiality for caveolin- or clathrin-mediated endocytosis.
Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos.
Impact
Larraín et al., Santiago, Chile. In Nat Cell Biol, 2006
xSyn4 interacts functionally and biochemically with the Wnt receptor Frizzled7 (xFz7) and its signal transducer Dishevelled (xDsh).
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