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Frizzled family receptor 6

FZD6, Fz6, Frizzled 6
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: Frizzled, FZD3, Wnt5a, FZD7, Frizzled-2
Papers on FZD6
Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.
New
Henry et al., Urbana, United States. In Exp Eye Res, Feb 2016
Numerous frizzled receptors (fzd1, fzd2, fzd3, fzd4, fzd6, fzd7, fzd8, and fzd10) and wnt ligands (wnt2b.a,
The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation.
New
Nathans et al., Baltimore, United States. In Dev Biol, Feb 2016
The present study uses conditional knockout alleles of the PCP genes Frizzled6 (Fz6), Vangl1, and Vangl2, together with a series of Cre drivers to interrogate the spatio-temporal domains of PCP gene action in the developing mouse epidermis required for follicle orientation.
Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles.
New
Nathans et al., Baltimore, United States. In Plos Genet, Sep 2015
In Frizzled6(-/-) (Fz6(-/-)) mice, hair follicle orientations on the head and back are nearly random at birth, but reorient during early postnatal development to eventually generate a nearly parallel anterior-to-posterior array.
Regulatory variant in FZD6 gene contributes to nonsyndromic cleft lip and palate in an African-American family.
New
Hecht et al., Houston, United States. In Mol Genet Genomic Med, Sep 2015
This region contained four genes, Frizzled-6 (FZD6), Matrilin-2 (MATN2), Odd-skipped related 2 (OSR2) and Solute Carrier Family 25, Member 32 (SLC25A32).
Identification of miR-199a-5p target genes in the skin keratinocyte and their expression in cutaneous squamous cell carcinoma.
New
Yoon et al., Seoul, South Korea. In J Dermatol Sci, Aug 2015
RESULTS: We identified new target genes, Bcam, Fzd6, and Wnt7a, as well as previously known targets, Ddr1 and Podxl.
FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer.
New
Kim Yoon et al., Seoul, South Korea. In Bmb Rep, Jun 2015
Among the members of the FZD family, FZD6 is broadly expressed in various tissues, and its overexpression has been reported in several cancers, suggesting an important role in cancer development.
Tumourigenic canine osteosarcoma cell lines associated with frizzled-6 up-regulation and enhanced side population cell frequency.
New
Stein et al., Madison, United States. In Vet Comp Oncol, Mar 2015
Frizzled-6 was upregulated to the greatest extent (7.78-fold) in tumourigenic cell lines compared with non-tumourigenic cell lines.
The role of stem/progenitor cells and Wnt/β-catenin signaling pathway in the patients with prostate cancer.
Bugdayci et al., Manisa, Turkey. In Minerva Urol Nefrol, 2014
The immunoreactivity of Frizzled 6 (Fzd 6) which is the receptor of Wnt family was also evaluated in all groups.
Identification of embryonic lethal genes in humans by autozygosity mapping and exome sequencing in consanguineous families.
Alkuraya et al., Riyadh, Saudi Arabia. In Genome Biol, 2014
In addition to revealing mutations in genes previously linked to embryonic lethality in severe cases, our approach revealed seven novel candidate genes (THSD1, PIGC, UBN1, MYOM1, DNAH14, GALNT14, and FZD6).
Otitis media in sperm-associated antigen 6 (Spag6)-deficient mice.
Wang et al., Jinan, China. In Plos One, 2013
The orientation of the ciliary basal feet was random in the middle ear epithelial cells of Spag6-deficient mice, and there was an associated disrupted localization of the planar cell polarity (PCP) protein, FZD6.
Genome-wide patterns of copy number variation in the diversified chicken genomes using next-generation sequencing.
Yang et al., Beijing, China. In Bmc Genomics, 2013
Two genes, FZD6 and LIMS1, related to disease susceptibility/resistance are covered by CNVRs.
A consideration of the evidence that genetic defects in planar cell polarity contribute to the etiology of human neural tube defects.
Review
Harris et al., Vancouver, Canada. In Birth Defects Res A Clin Mol Teratol, 2012
PCP rare putative mutations had a weaker role in myelomeningocele (SB), being found in approximately 6% of cases and cumulated across CELSR1, FUZ, FZD6, PRICKLE1, VANGL1, and VANGL2.
FZD6 encoding the Wnt receptor frizzled 6 is mutated in autosomal-recessive nail dysplasia.
GeneRIF
Betz et al., Islamabad, Pakistan. In Br J Dermatol, 2012
The present results emphasize the role of FZD6 mutation in Wnt pathways in nail development.
FZD6 is a novel gene for human neural tube defects.
GeneRIF
Capra et al., Genova, Italy. In Hum Mutat, 2012
This study demonstrates that rare nonsynonymous variants in FZD6 may contribute to NTDs in humans and enlarges the spectrum of mutations that link PCP pathway to Neural tube defects (NTDs).
Analysis of target genes regulated by chronic electroconvulsive therapy reveals role for Fzd6 in depression.
GeneRIF
Duman et al., New Haven, United States. In Biol Psychiatry, 2012
The current study provides insight into the global changes in gene transcription mediated by chr-ECS and suggests that Fzd6 signaling could represent a novel target for development of novel antidepressants.
Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas.
GeneRIF
Sala et al., London, United Kingdom. In Oncotarget, 2011
When transplanted into immunodeficient mice, neuroblastoma cells expressing the Fzd6 marker grow more aggressively than their Fzd6 negative counterparts. Fzd6 is a new surface marker of aggressive neuroblastoma cells with stem cell-like features.
[Of genes and nails].
GeneRIF
Dereure, Montpellier, France. In Ann Dermatol Venereol, 2011
Mutations in this gene cause nail dysplasia. Review.
WNT signaling in stem cell biology and regenerative medicine.
Review
Katoh, Tokyo, Japan. In Curr Drug Targets, 2008
FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, FZD10, LRP5, LRP6, and ROR2 are transmembrane receptors transducing WNT signals based on ligand-dependent preferentiality for caveolin- or clathrin-mediated endocytosis.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Review
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
WNT/PCP signaling pathway and human cancer (review).
Review
Katoh, Tokyo, Japan. In Oncol Rep, 2005
Human WNT5A, WNT5B, and WNT11 are representative non-canonical WNTs transducing PCP signals through FZD3 or FZD6 receptors, and ROR1, ROR2 or PTK7 co-receptors.
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