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FYVE and coiled-coil domain containing 1

FYCO1, RUN and FYVE domain containing 3, FYVE and coiled-coil domain containing 1, MEM-2
This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: Rab7, LC3, CAN, V1a, ACID
Papers using FYCO1 antibodies
SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans
Johansen Terje et al., In The Journal of Cell Biology, 2008
... polyclonal antibody (Cell Signaling Technology); anti-GFP rabbit polyclonal antibody (Abcam); anti-MBP mouse monoclonal antibody (Sigma-Aldrich); anti-FYCO1 mouse polyclonal antibody (Abnova); anti-Atg16L rabbit polyclonal antibody ...
Papers on FYCO1
FYCO1 Contains a C-terminally Extended, LC3A/B-preferring LC3-interacting Region (LIR) Motif Required for Efficient Maturation of Autophagosomes during Basal Autophagy.
Johansen et al., Tromsø, Norway. In J Biol Chem, Jan 2016
FYCO1 (FYVE and coiled-coil protein 1) is a transport adaptor that binds to phosphatidylinositol 3-phosphate, to Rab7, and to LC3 (microtubule-associated protein 1 light chain 3) to mediate transport of late endosomes and autophagosomes along microtubules in the plus end direction.
Salmonella Disrupts Host Endocytic Trafficking by SopD2-Mediated Inhibition of Rab7.
Brumell et al., Toronto, Canada. In Cell Rep, Oct 2015
Consequently, this limits Rab7 interaction with its dynein- and kinesin-binding effectors RILP and FYCO1 and thereby disrupts host-driven regulation of microtubule motors.
Phenotypes of Recessive Pediatric Cataract in a Cohort of Children with Identified Homozygous Gene Mutations (An American Ophthalmological Society Thesis).
Alkuraya et al., Riyadh, Saudi Arabia. In Trans Am Ophthalmol Soc, Sep 2015
Ten families had a founder CRYBB1 deletion (all with bilateral central pulverulent cataract), two had the same missense mutation in CRYAB (both with bilateral juvenile cataract with marked variable expressivity), and two had different mutations in FYCO1 (both with bilateral posterior capsular abnormality).
Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth.
Stenmark et al., Oslo, Norway. In Nature, May 2015
These contact sites mediate transfer of the microtubule motor kinesin 1 from protrudin to the motor adaptor FYCO1 on LEs.
PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion.
Li et al., Shenyang, China. In Cell Death Dis, 2014
Although RUFY3 (RUN and FYVE domain containing 3)/SINGAR1 (single axon-related1)/RIPX (Rap2 interacting protein X) has an important role in neuronal development, its pathophysiologic role and relevance to cancer are still largely unknown.
Differentiation state-specific mitochondrial dynamic regulatory networks are revealed by global transcriptional analysis of the developing chicken lens.
Kantorow et al., Boca Raton, United States. In G3 (bethesda), 2014
These included differences in the expression levels of metabolic (DUT, PDK1, SNPH), autophagy (ATG3, ATG4B, BECN1, FYCO1, WIPI1), and mitophagy (BNIP3L/NIX, BNIP3, PARK2, p62/SQSTM1) transcripts between lens epithelial cells and lens fiber cells.
Autophagy in the eye: implications for ocular cell health.
Boesze-Battaglia et al., Philadelphia, United States. In Exp Eye Res, 2014
Numerous studies delineating the role of Atg5, Vsp34 as well as FYCO1 in maintenance of lens transparency are discussed.
Cutting edge: FYCO1 recruitment to dectin-1 phagosomes is accelerated by light chain 3 protein and regulates phagosome maturation and reactive oxygen production.
Underhill et al., Los Angeles, United States. In J Immunol, 2014
In this study, we report that FYVE and coiled-coil domain containing 1 (FYCO1), a protein previously implicated in autophagosome trafficking, is recruited directly by LC3 to Dectin-1 phagosomes.
Rab7 and Arl8 GTPases are necessary for lysosome tubulation in macrophages.
Botelho et al., Toronto, Canada. In Traffic, 2012
Here, we show that macrophage cell lines readily form TLs after LPS exposure, with a requirement for the Rab7 GTPase and its effectors RILP (Rab7-interacting lysosomal protein) and FYCO1 (coiled-coil domain-containing protein 1), which respectively modulate the dynein and kinesin microtubule motor proteins.
Spatial expression patterns of autophagy genes in the eye lens and induction of autophagy in lens cells.
Kantorow et al., Boca Raton, United States. In Mol Vis, 2011
PURPOSE: Mutation of the autophagy gene FYVE (named after the four cysteine-rich proteins: Fab 1 [yeast orthologue of PIKfyve], YOTB, Vac 1 [vesicle transport protein], and EEA1) and coiled coil containing 1 (fyco1) causes human cataract suggesting a role for autophagy in lens function.
Mutations in FYCO1 cause autosomal-recessive congenital cataracts.
Hejtmancik et al., Bethesda, United States. In Am J Hum Genet, 2011
FYCO1 is involved in lens development and transparency in humans, and mutations in this gene are one of the most common causes of autosomal-recessive congenital cataracts in the Pakistani population.
Rab7: role of its protein interaction cascades in endo-lysosomal traffic.
Hong et al., Xiamen, China. In Cell Signal, 2011
We summarize here the key protein interaction cascades of Rab7 by focusing on endo-lysosomal trafficking regulated by its interaction with HOPs, RILP, ORP1L, FYCO1 and Mon1/Sand1-CCZ1 complex.
FYCO1: linking autophagosomes to microtubule plus end-directing molecular motors.
Johansen et al., Tromsø, Norway. In Autophagy, 2010
We have recently reported that a previously uncharacterized protein FYVE and coiled-coil domain-containing 1 (FYCO1) functions as an adapter linking autophagosomes to microtubule plus end-directed molecular motors.
Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Marcus et al., Bochum, Germany. In Langenbecks Arch Surg, 2010
Detailed gene expression analysis showed a variety of genes whose upregulation (platelet-derived growth factor receptor alpha polypeptide, solute carrier family 39 member 14, solute carrier family 2 member 3, pleiotrophin, trophinin, pleckstrin and Sec7 domain containing 3, enolase 2, biglycan, SH3 and cysteine-rich domain, matrix metalloproteinases 16) and whose downregulation (tissue inhibitor of metalloproteinase 4, hairy/enhancer of split related with YRPW motif 2, protein tyrosine phosphatase receptor-type Z polypeptide 1, SH3 domain GRB2-like 2, microtubule-associated protein 7, potassium voltage-gated channel shaker-related subfamily member 1, RUN and FYVE domain containing 3, Sin3A-associated protein 18 kDa, proline-rich 4, calcium/calmodulin-dependent protein kinase ID, myeloid/lymphoid or mixed-lineage leukemia translocated to 3, insulin-like growth factor binding protein 5, nucleoside diphosphate-linked moiety X-type motif 9, NudC domain containing 3, imprinted in Prader-Willi syndrome, TAF6-like RNA polymerase II p300/CBP-associated factor 65 kDa, WD repeat and SOCS box-containing 2, adenosine diphosphate ribosylation factor 3, KRR1, proliferation-associated 2G4; CD36, complement component (3b/4b) receptor 1, solute carrier family 4 sodium bicarbonate cotransporter member 4, lipoprotein lipase (LPL), GATA binding protein 3, LPL, glutathione peroxidase 3, D: -aspartate oxidase, apolipoprotein E, sphingomyelin phosphodiesterase acid-like 3A) were associated with poor clinical outcome in terms of development of metastatic or recurrent disease.
FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport.
Johansen et al., Tromsø, Norway. In J Cell Biol, 2010
We have characterized the LC3-, Rab7-, and phosphatidylinositol-3-phosphate-binding domains in FYCO1 and mapped part of the CC region essential for MT plus end-directed transport.
The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3.
Dumanski et al., Stockholm, Sweden. In Eur J Hum Genet, 2002
Maps to a region of chromosome 3p21.3 which is frequently deleted in tumors.
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