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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

FYN binding protein

Fyb, ADAP, SLAP-130
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: SLP-76, Src, alpha-Synuclein, CAN, V1a
Papers on Fyb
Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration.
New
Freund et al., Berlin, Germany. In Mol Cell Proteomics, Nov 2015
Signal propagation from activated receptors to integrins depends on scaffolding proteins such as the adhesion and degranulation promoting adaptor protein (ADAP)(1).
Negative Regulation of Memory Phenotype CD8 T Cell Conversion by Adhesion and Degranulation-Promoting Adapter Protein.
New
Shimizu et al., Minneapolis, United States. In J Immunol, Nov 2015
We have identified a novel negative regulatory role for adhesion and degranulation-promoting adapter protein (ADAP) in CD8 T cell function.
Molecular identification of rare FY*Null and FY*X alleles in Caucasian thalassemic family from Sardinia.
New
Pagliaro et al., Bologna, Italy. In Transfus Apher Sci, Oct 2015
We speculate on the frequency of FY*X and FY*Null alleles in Caucasian and Black people; further, we focused on the association of FY*X allele with weak Fyb antigen expression on red blood cells and its identification performing high sensitivity serological typing methods or genotyping.
Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1.
New
Teixidó et al., Madrid, Spain. In Mol Biol Cell, Oct 2015
Correlating with activation by the chemokine CXCL12 of T-lymphocyte attachment to α4β1 ligands, a transient stimulation in the association of Vav1 with SLP-76, Pyk2, and ADAP was observed.
The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection.
New
Wang et al., Shanghai, China. In Plos Pathog, Apr 2015
This study showed that ADAP (Adhesion and Degranulation-promoting Adapter Protein) formed a complex with TRAF6 and TAK1 in CD8+ T cells, and activated SMAD3 to increase autocrine TGF-β1 production.
The adhesion- and degranulation-promoting adaptor protein and its role in the modulation of experimental autoimmune encephalomyelitis.
Review
Reinhold et al., Magdeburg, Germany. In Crit Rev Immunol, 2014
The cytosolic adhesion- and degranulation-promoting adaptor protein (ADAP) is expressed in T cells, natural killer cells, myeloid cells, and platelets.
The Fyn-ADAP Axis: Cytotoxicity Versus Cytokine Production in Killer Cells.
Review
Malarkannan et al., Milwaukee, United States. In Front Immunol, 2014
While the Fyn-PI(3)K pathway controls multiple functions, including cytotoxicity, cell development, and cytokine production, the Fyn-ADAP pathway preferentially regulates cytokine production in NK and T cells.
Functions of the neuron-specific protein ADAP1 (centaurin-α1) in neuronal differentiation and neurodegenerative diseases, with an overview of structural and biochemical properties of ADAP1.
Review
Reiser et al., In Biol Chem, 2014
The ADAP subfamily, also designated centaurin-α, has an N-terminal ArfGAP domain followed by two PH domains.
Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.
Impact
Malarkannan et al., Milwaukee, United States. In Nat Immunol, 2013
However, a complex of Fyn and the adaptor ADAP exclusively regulated the production of inflammatory cytokines but not cytotoxicity in NK cells.
Integrin signalling and function in immune cells.
Review
Wang et al., Shanghai, China. In Immunology, 2012
This review discusses the key signalling complexes regulating integrin activation and function in both 'inside-out' and 'outside-in' pathways in T lymphocytes, including kinases, SLP-76, VAV1, ADAP, SKAP-55, RapL, RIAM, Rap1, Talin and Kindlin.
Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.
GeneRIF
Zarbock et al., Münster, Germany. In J Exp Med, 2012
SLP-76 and ADAP are involved in E-selectin-mediated integrin activation and neutrophil recruitment to inflamed kidneys, which may underlie the development of life-threatening ischemia-reperfusion-induced acute kidney injury in humans.
A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1).
GeneRIF
Farndale et al., Belfast, United Kingdom. In J Thromb Haemost, 2012
ADAP plays a role in mediating platelet activation via the collagen-binding integrin alpha(2) beta(1).
TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation.
GeneRIF
Simske et al., Cleveland, United States. In Am J Physiol Cell Physiol, 2011
TM4SF10, possibly through ADAP, may regulate Fyn activity
Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization.
GeneRIF
Barda-Saad et al., Ramat Gan, Israel. In Mol Cell Biol, 2011
a functional cooperation between Nck and ADAP in stabilizing the recruitment of WASp to SLP76 regulates actin rearrangement.
The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.
GeneRIF
Shimizu et al., Minneapolis, United States. In J Immunol, 2011
Data suggest that the presence or absence of associated SKAP55 defines functionally distinct pools of ADAP.
The mitochondria permeability transition pore complex in the brain with interacting proteins - promising targets for protection in neurodegenerative diseases.
Review
Reiser et al., Magdeburg, Germany. In Biol Chem, 2010
We describe the involvement of the 18-kDa translocator protein (TSPO; previously called peripheral benzodiazepine receptor), and of two new mitochondrial proteins, that is, 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and p42(IP4) (also designated centaurin alpha1; ADAP 1), in the control of the PTP.
Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1.
Impact
GeneRIF
Shimizu et al., Minneapolis, United States. In Science, 2007
findings provide new insights into ADAP function and the mechanism by which CARMA1 regulates NF-kappaB activation in T cells
SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates.
Impact
Rudd et al., London, United Kingdom. In Nat Immunol, 2003
Enhanced conjugation is comparable to that induced by adhesion and degranulation-promoting adaptor protein (ADAP), a binding partner of SKAP-55, and is abrogated by deletion of the SKAP-55 SH3 domain.
Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap.
Impact
GeneRIF
Penninger et al., Toronto, Canada. In Science, 2001
Regulates TCR-induced integrin clustering and adhesion.
Coupling of the TCR to integrin activation by Slap-130/Fyb.
Impact
GeneRIF
Koretzky et al., Philadelphia, United States. In Science, 2001
Important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function and for T cells to respond fully to activating signals.
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