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Tissue specific transplantation antigen P35B

FX, P35B, Protein FX, red cell NADP(H)-binding protein, GDP-l-fucose synthetase, GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase, TSTA3
Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, FIX, FVIII, ACID
Papers using FX antibodies
The effect of a deficiency on chiasma distribution and frequency in a male of Stauroderus scalaris (Orthoptera)
Supplier
Mezzanotte R. et al., In European Journal of Histochemistry : EJH, 1980
... Slides were analyzed using a Leica DMLB fluorescence microscope equipped with a charge-coupled device camera (Leica DFC350 FX, Leica Microsystems) with three independent ...
A radioautographic study of the hepatic uptake of circulating carcinoembryonic antigen by the mouse
Supplier
Reitsma Pieter H., In PLoS ONE, 1976
... first set of sections (A, B, and C) FX variants are stained with rabbit anti-human FX (Eurogentec followed by highly sensitive ...
Papers on FX
Investigation of the S1/ICT equilibrium in fucoxanthin by ultrafast pump-dump-probe and femtosecond stimulated Raman scattering spectroscopy.
New
Vengris et al., Vilnius, Lithuania. In Photosynth Res, Feb 2016
UNASSIGNED: Time-resolved multi-pulse spectroscopic methods-pump-dump-probe (PDP) and femtosecond stimulated Raman spectroscopy-were used to investigate the excited state photodynamics of the carbonyl group containing carotenoid fucoxanthin (FX).
NG2 proteoglycan as a pericyte target for anticancer therapy by tumor vessel infarction with retargeted tissue factor.
New
Schwöppe et al., Münster, Germany. In Oncotarget, Feb 2016
Chromatography-purified tTF-TAA showed identical Factor X (FX)-activating procoagulatory activity as the model compound tTF-NGR with Km values of approx.
Automated radiosynthesis of [(11)C]L-deprenyl-D2 and [(11)C]D-deprenyl using a commercial platform.
New
Engler et al., Montevideo, Uruguay. In Appl Radiat Isot, Jan 2016
One step N-alkylation with [(11)C]MeI or [(11)C]MeOTf was performed using the automated platform TRACERlab® FX-C Pro.
A novel Ala275Val mutation in factor X gene influences its structural compatibility and impairs intracellular trafficking and coagulant activity.
New
Zhang et al., Changsha, China. In Thromb Res, Jan 2016
UNASSIGNED: Factor X (FX) deficiency is an autosomal recessive severe bleeding disorder.
Improving care and treatment options for women and girls with bleeding disorders.
Review
New
Kulkarni, East Lansing, United States. In Eur J Haematol, Dec 2015
They can also be affected by other hereditary bleeding diatheses such as von Willebrand disease, platelet dysfunction defects or deficiencies of coagulation factors (F) such as FI, FII, FV, FVII, FX, FXI and FXIII.
Structural and Luminescence Features of Lithium-Doped p-Type Film-Like ZnO Nanorods.
New
Hong et al., In J Nanosci Nanotechnol, Nov 2015
The p-type features of synthesized Li-doped ZnO nanostructures were analyzed using a photoluminescence measurement using a He-Cd laser as an excitation source at 10 K. Closer investigation of the fine donor- and acceptor-bound exciton emission peaks from the low temperature PL spectra revealed the occurrence of several peaks related to free excitons (FX), excitons bound to acceptor (A(0)X), free electron to the acceptor transition peak (FA), and its LO phonon replicas.
Factor XI and contact activation as targets for antithrombotic therapy.
Review
New
Gruber et al., Nashville, United States. In J Thromb Haemost, Aug 2015
The most commonly used anticoagulants produce therapeutic antithrombotic effects either by inhibiting thrombin or factor Xa (FXa) or by lowering the plasma levels of the precursors of these key enzymes, prothrombin and FX.
Complex history of the discovery and characterization of congenital factor X deficiency.
Review
New
Randi et al., Padova, Italy. In Semin Thromb Hemost, Jun 2015
Factor X (FX) plays a pivotal role in blood coagulation.
[General and Specific Mechanisms of Visual Cognitive Function Impairment in People with FMRP Deficit].
Review
New
Gorbachevskaya et al., In Zh Vyssh Nerv Deiat Im I P Pavlova, May 2015
The results obtained by subjects with FX syndrome are compared with ASD data, syndrome with closed behavioral phenotype.
Role of prothrombin complex concentrate in perioperative coagulation therapy.
Review
Durila et al., Baltimore, United States. In J Intensive Care, 2013
Prothrombin complex concentrate (PCC) is a term to describe pharmacological products that contain lyophilized, human plasma-derived vitamin K-dependent factors (F), FII, FVII, FIX, FX, and various amounts of proteins C and S. PCCs can be rapidly reconstituted in a small volume (20 ml for about 500 international units (IU)) at bedside and administered regardless of the patient's blood type.
Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement.
Impact
Byrnes et al., Bethesda, United States. In Nat Med, 2013
Adenovirus type 5 (Ad5) specifically binds coagulation factor X (FX), and FX is normally essential for intravenously injected Ad5 vectors to transduce the liver.
Coagulation factor X activates innate immunity to human species C adenovirus.
Impact
Shayakhmetov et al., Seattle, United States. In Science, 2012
We modeled the interface of human species C adenovirus (HAdv) interaction with coagulation factor X (FX) and introduced a mutation that abrogated formation of the HAdv-FX complex.
A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model.
Impact
Hattori et al., Gotemba, Japan. In Nat Med, 2012
To overcome these drawbacks, we generated a humanized bispecific antibody to factor IXa (FIXa) and factor X (FX), termed hBS23, that places these two factors into spatially appropriate positions and mimics the cofactor function of FVIII.
Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputation.
GeneRIF
Lin et al., Beijing, China. In Immunol Res, 2012
Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV
Fucose-deficient hematopoietic stem cells have decreased self-renewal and aberrant marrow niche occupancy.
GeneRIF
Zhou et al., Cleveland, United States. In Transfusion, 2010
Fucosylation-modified Notch receptor may represent a novel extrinsic regulator for hematopoietic stem cells (HSC) engraftment and HSC niche maintenance.
Adenovirus serotype 5 hexon mediates liver gene transfer.
Impact
Baker et al., London, United Kingdom. In Cell, 2008
Here, we show that FX binds to the Ad5 hexon, not fiber, via an interaction between the FX Gla domain and hypervariable regions of the hexon surface.
Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein.
Impact
Nemerson et al., New York City, United States. In Nat Med, 2003
Tissue factor (TF) is an essential enzyme activator that forms a catalytic complex with FVII(a) and initiates coagulation by activating FIX and FX, ultimately resulting in thrombin formation.
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