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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

3-ketodihydrosphingosine reductase

FVT1, 3-ketodihydrosphingosine reductase, Follicular Lymphoma Variant Translocation 1, 3-ketodihydrosphingosine reductase FVT1
The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on FVT1
Expression of the follicular lymphoma variant translocation 1 gene in diffuse large B-cell lymphoma correlates with subtype and clinical outcome.
GeneRIF
Cesarman et al., New York City, United States. In Am J Clin Pathol, 2008
FVT1 is significantly underexpressed by germinal center-type diffuse large B-cell lymphoma compared with non-germinal center-type DLBCL, follicular lymphoma, & normal tonsil control samples. Increased expression of FVT1 correlated with decreased survival.
Candidate screening of the bovine and feline spinal muscular atrophy genes reveals no evidence for involvement in human motor neuron disorders.
GeneRIF
Talbot et al., Oxford, United Kingdom. In Neuromuscul Disord, 2008
Data show that mutations in FVT1 do not contribute significantly to the cause of motor neuron diseases in the human population.
A missense mutation in the 3-ketodihydrosphingosine reductase FVT1 as candidate causal mutation for bovine spinal muscular atrophy.
GeneRIF
Förster et al., München, Germany. In Proc Natl Acad Sci U S A, 2007
G-to-A missense mutation in FVT1, encoding 3-ketodihydrosphingosine reductase, is a strong candidate for causality of spinal muscular atrophy in cattle.
FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane.
GeneRIF
Igarashi et al., Sapporo, Japan. In J Biol Chem, 2004
FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane
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