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Fucosyltransferase 6

FUT6, Fuc-TVI, fucosyltransferase VI
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: fucosyltransferase, Alpha-1, FUT5, CAN, HAD
Papers on FUT6
Inflammatory cytokines regulate the expression of glycosyltransferases involved in the biosynthesis of tumor-associated sialylated glycans in pancreatic cancer cell lines.
New
Peracaula et al., Girona, Spain. In Cytokine, Sep 2015
IL-6 and TNFα treatments increased the levels of SLe(x) and Le(y) antigens in MDPanc-3 cells and, similarly, the mRNA expression of ST3GAL3-4, FUT1-2 and FUT6, related to these Lewis-type antigens' biosynthesis, were increased.
Transcriptional Downregulation by Nucleotide Substitution with the Minor Allele of rs3760776 Located in the Promoter of FUT6 Gene.
New
Lee et al., Seoul, South Korea. In Biochem Genet, Jun 2015
We examined the promoter activity of an association signal in an upstream region of the gene encoding fucosyltransferae 6 (FUT6) identified from a recent genomewide association study for the N-glycan level.
Single nucleotide polymorphisms related to vitamin B12 serum levels in autoimmune gastritis patients with or without pernicious anaemia.
New
Annibale et al., Roma, Italy. In Dig Liver Dis, Apr 2015
FUT6 (rs3760776) AA genotype was present in four (4.8%) autoimmune gastritis patients (all pernicious anaemia) and three (1.7%)
Variation at ABO histo-blood group and FUT loci and diffuse and intestinal gastric cancer risk in a European population.
New
González et al., Barcelona, Spain. In Int J Cancer, Mar 2015
were associated with diffuse-type GC; however, conditional models with other ABO variants indicated that the associations were largely due to allelic blood group A. One variant in FUT5 was also associated with diffuse-type GC, and four variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 with intestinal-type GC.
Increased fucosylation has a pivotal role in invasive and metastatic properties of head and neck cancer stem cells.
Papagerakis et al., Ann Arbor, United States. In Oncotarget, 2015
We found fucosyltransferases FUT3 and FUT6 highly up-regulated, increased SLex expression and increased adhesion by shear flow assays in orospheres.
B4GALNT2 gene expression controls the biosynthesis of Sda and sialyl Lewis X antigens in healthy and cancer human gastrointestinal tract.
Harduin-Lepers et al., Villeneuve-d'Ascq, France. In Int J Biochem Cell Biol, 2014
Concomitant expression of B4GALNT2 and siRNA-mediated inhibition of FUT6, the major fucosyltransferase involved in sLe(x) synthesis in colon, resulted in a cumulative inhibition of sLe(x).
The role of fucosylation in the promotion of endothelial progenitor cells in neovascularization and bone repair.
Dong et al., Suzhou, China. In Biomaterials, 2014
Expression of α1,3-fucosyltransferase VI (FucT VI) in the EPCs enhanced sLe(x) synthesis, E- and P-selectin-binding, and EPC adhesion to tumor necrosis factor-α-stimulated human umbilical vein endothelial cells in culture.
Homing of neural stem cells from the venous compartment into a brain infarct does not involve conventional interactions with vascular endothelium.
Khaldoyanidi et al., San Diego, United States. In Stem Cells Transl Med, 2014
In the present studies, we found that interactions of hNSCs in vitro on the luminal surface of human umbilical vein endothelial cells was enhanced following enforced expression of cutaneous lymphocyte antigen on cell surface moieties by incubation of hNSCs with fucosyltransferase VI and GDP-fucose (fhNSCs).
Characterisation of FUT4 and FUT6 α-(1 → 2)-fucosyltransferases reveals that absence of root arabinogalactan fucosylation increases Arabidopsis root growth salt sensitivity.
Dupree et al., Cambridge, United Kingdom. In Plos One, 2013
Monosaccharide analysis of Arabidopsis leaf AGP extracts revealed a significant reduction in L-Fucose content in the fut4 mutant, but not in the fut6 mutant.
A hybrid dynamic Bayesian network approach for modelling temporal associations of gene expressions for hypertension diagnosis.
Seker et al., In Conf Proc Ieee Eng Med Biol Soc, 2013
Results show that cell regulation FOXQ1 may inhibit the expression of focusyltransferase-6 (FUT6) and that ABCG1 ATP-binding cassette sub-family G may also play inhibitory role against NR2E3 nuclear receptor sub-family 2 and CGB2 Chromatin Gonadotrophin.
Functional analysis of α1,3/4-fucosyltransferase VI in human hepatocellular carcinoma cells.
GeneRIF
Wu et al., Shanghai, China. In Biochem Biophys Res Commun, 2012
these results suggest that FUT6 plays an important role in hepatocellular carcinoma growth by regulating the PI3K/Akt signaling pathway.
The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach.
GeneRIF
Dall'olio et al., Varese, Italy. In Int J Biochem Cell Biol, 2011
The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach.
Development of immunohistochemistry assays to assess GALNT14 and FUT3/6 in clinical trials of dulanermin and drozitumab.
GeneRIF
Ashkenazi et al., San Francisco, United States. In Clin Cancer Res, 2010
GALNT14 and FUT3/6 H-scores were significantly higher in non-small cell lung cancer cell lines sensitive to dulanermin and drozitumab versus resistant cell lines
Activation of host antiviral RNA-sensing factors necessary for herpes simplex virus type 1-activated transcription of host cell fucosyltransferase genes FUT3, FUT5, and FUT6 and subsequent expression of sLe(x) in virus-infected cells.
GeneRIF
Olofsson et al., Göteborg, Sweden. In Glycobiology, 2009
results suggested that PKR is the primary target for HSV-1 early RNA during induction of FUT3, FUT5, and FUT6
Transcriptional regulation of the fucosyltransferase VI gene in hepatocellular carcinoma cells.
GeneRIF
Matsumoto et al., Funabashi, Japan. In Glycoconj J, 2008
two defined regions in the 5'-flanking region of the FUT VI transcription start site are critical for FUT VI transcription in HepG2 cells
Carbohydrates and derivatives as potential drug candidates with emphasis on the selectin and linear-B area.
Review
Ohrlein, Basel, Switzerland. In Mini Rev Med Chem, 2001
The respective transferases investigated are alpha(1-3)galactosyltransferase, beta(1-3)galactosyltransferase, beta(1-4)galactosyltransferase, alpha(2-3)sialyltransferase, alpha(1- 3)fucosyltransferase III and alpha(1-3)fucosyltransferase VI.
Substrate and donor specificity of glycosyl transferases.
Review
Oehrlein et al., Basel, Switzerland. In Glycoconj J, 1999
A survey of the involved enzymes: beta(1-3) and beta(1-4)galactosyl transferases, alpha(2-3)sialyl transferase, FucT III and FucT VI reveals that the enzymatic synthesis is highly efficient for the rapid preparation of sialyl Lewis(x)- and sialyl Lewis(a)-derivatives.
Advances in molecular genetics of alpha-2- and alpha-3/4-fucosyltransferases.
Review
Mollicone et al., Villejuif, France. In Transfus Clin Biol, 1997
Polymorphic genes FUT1-FUT2 and FUT3-FUT5-FUT6 are organized in two clusters and each gene is partially or totally inactivated by different types of point mutations (nonsense, missense and frame shift), complete gene deletion or a fusion gene.
[Carbohydrate antigens in carcinoma invasion and metastasis].
Review
Irimura et al., Tokyo, Japan. In Nihon Geka Gakkai Zasshi, 1996
Human fucosyltransferase VI cDNA has been stably transfected into the low expresser variant cells.
Molecular genetics of H, Se, Lewis and other fucosyltransferase genes.
Review
Oriol et al., Villejuif, France. In Transfus Clin Biol, 1994
The alpha-3-fucosyltransferases: FUT3 (Lewis) of exocrine secretions; FUT4 (myeloid) of white cells and brain; FUT5 whose tissue distribution has not been defined as yet; FUT6 (plasma) present in plasma, renal proximal tubules and hepatocytes; FUT7 (leukocyte) found in neutrophils.
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