New in vitro models to study amyotrophic lateral sclerosis.
Sheffield, United Kingdom. In Brain Pathol, Feb 2016
The identification of mutations in transactive response DNA-binding protein gene (TARDBP), fused in sarcoma (FUS) and, more recently, a GGGGCC-hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) and their link with familial ALS have provided new avenues of investigation and hypotheses on the pathophysiology of this devastating disease.
Novel Sites of Neuroprotective Action of Dimebon (Latrepirdine).
Cardiff, United Kingdom. In Mol Neurobiol, Oct 2015
In the latter, neurodegenerative effects are attributed to a group of aggregate-prone proteins such as γ-synuclein, hyperphosphorylated tau, and fused in sarcoma (FUS), which are engaged in numerous neurological diseases.