Obesity and FTO: Changing Focus at a Complex Locus.
Cambridge, United Kingdom. In Cell Metab, 2014
The fat mass and obesity-associated (FTO) gene was placed center stage when common intronic variants within the gene were robustly associated with human obesity.
Mechanism and function of oxidative reversal of DNA and RNA methylation.
In Annu Rev Biochem, 2013
Characterization of two additional AlkB family proteins, FTO and ALKBH5, showed that they possess demethylase activity toward N(6)-methyladenosine (m(6)A) in RNA, indicating that members of this subfamily of dioxygenases have a general function in demethylating nucleic acids.
[Pancreatitis, pancreatic cancer and obesity: hypothesis and facts].
In Eksp Klin Gastroenterol, 2013
There are also genetic risk factors for PC: a statistically significant interaction between IVS1-27777C> and IVS1-23525A>T genotypes of the FTO gene with obesity and the PC risk: AA genotype in patients with BMI < 25 kg/m2 reduced PC risk by 22%-28% (p < 0,0001), and with BMI ≥ 25 kg/m2 was associated with 54%-60% increased PC risk (p < 0,0015).