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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fat mass and obesity associated

FTO
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: fibrillin-1, AGE, HAD, Insulin, CAN
Papers on FTO
Association of rs9939609 Polymorphism with Metabolic Parameters and FTO Risk Haplotype Among Tunisian Metabolic Syndrome.
New
Kefi et al., Tunisia. In Metab Syndr Relat Disord, Feb 2016
BACKGROUND: Variants in the fat mass and obesity-associated (FTO) gene are associated with obesity and type 2 diabetes mellitus.
A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP.
New
Günel et al., New Haven, United States. In J Hum Genet, Feb 2016
UNASSIGNED: The fat mass and obesity associated (FTO) gene has previously been associated with a variety of diseases and conditions, notably obesity, acute coronary syndrome and metabolic syndrome.
Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men.
New
Pitha et al., Praha, Czech Republic. In Clin Chim Acta, Feb 2016
This study aimed to confirm the effect of common putative CVD-associated gene variants (FTO rs17817449, KIF6 rs20455, 9p21 rs10757274 and 2q36.3 rs2943634) on CVD manifestation, and determine whether this effect differs between younger (< 50years) and older CVD patients.
FTO gene variant modulates the neural correlates of visual food perception.
New
Tittgemeyer et al., Köln, Germany. In Neuroimage, Feb 2016
UNASSIGNED: Variations in the fat mass and obesity associated (FTO) gene are currently the strongest known genetic factor predisposing humans to non-monogenic obesity.
A systematic review of genetic variants associated with metabolic syndrome in patients with schizophrenia.
Review
New
Seedat et al., Cape Town, South Africa. In Schizophr Res, Jan 2016
Several genes showed strong evidence for an association with MetS in patients with schizophrenia, including the fat mass and obesity associated gene (FTO), leptin and leptin receptor genes (LEP, LEPR), methylenetetrahydrofolate reductase (MTHFR) gene and the serotonin receptor 2C gene (HTR2C).
Meta-analysis indicates that SNP rs9939609 within FTO is not associated with major depressive disorder (MDD) in Asian population.
New
Rao et al., Chengdu, China. In J Affect Disord, Jan 2016
The fat mass- and obesity-associated (FTO) gene, in particular the single nucleotide polymorphism (SNP) rs9939609, has been identified as a genetic risk loci associated with MDD.
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.
New
Impact
Kellis et al., Macedonia. In N Engl J Med, Oct 2015
The FTO region harbors the strongest genetic association with obesity, yet the mechanistic basis of this association remains elusive.
The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.
Review
New
Essigmann et al., Cambridge, United States. In J Biol Chem, Sep 2015
Nine mammalian AlkB homologs exist (ALKBH1-8, FTO), but only a subset functions as DNA/RNA repair enzymes.
Associations between FTO genotype and total energy and macronutrient intake in adults: a systematic review and meta-analysis.
Review
New
Food4Me et al., Pamplona, Spain. In Obes Rev, Aug 2015
Risk variants of fat mass and obesity-associated (FTO) gene have been associated with increased obesity.
Role of FTO in Adipocyte Development and Function: Recent Insights.
Review
Sellayah et al., Reading, United Kingdom. In Int J Endocrinol, 2014
In 2007, FTO was identified as the first genome-wide association study (GWAS) gene associated with obesity in humans.
Obesity and FTO: Changing Focus at a Complex Locus.
Review
Impact
Coll et al., Cambridge, United Kingdom. In Cell Metab, 2014
The fat mass and obesity-associated (FTO) gene was placed center stage when common intronic variants within the gene were robustly associated with human obesity.
Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.
Impact
Leibel et al., New York City, United States. In Cell Metab, 2014
Common polymorphisms in the first intron of FTO are associated with increased body weight in adults.
Obesity-associated variants within FTO form long-range functional connections with IRX3.
Impact
Nóbrega et al., Chicago, United States. In Nature, 2014
Genome-wide association studies (GWAS) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes (T2D).
Mechanism and function of oxidative reversal of DNA and RNA methylation.
Review
Impact
Zhang et al., In Annu Rev Biochem, 2013
Characterization of two additional AlkB family proteins, FTO and ALKBH5, showed that they possess demethylase activity toward N(6)-methyladenosine (m(6)A) in RNA, indicating that members of this subfamily of dioxygenases have a general function in demethylating nucleic acids.
[Pancreatitis, pancreatic cancer and obesity: hypothesis and facts].
Review
Tov et al., In Eksp Klin Gastroenterol, 2013
There are also genetic risk factors for PC: a statistically significant interaction between IVS1-27777C> and IVS1-23525A>T genotypes of the FTO gene with obesity and the PC risk: AA genotype in patients with BMI < 25 kg/m2 reduced PC risk by 22%-28% (p < 0,0001), and with BMI ≥ 25 kg/m2 was associated with 54%-60% increased PC risk (p < 0,0015).
Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study.
GeneRIF
Hubacek et al., Praha, Czech Republic. In Clin Chim Acta, 2012
Association between FTO 1st intron tagging variant and telomere length in middle aged women.
[FTO gene and his role in genetic determination of obesity].
Review
GeneRIF
Hubáček et al., In Vnitr Lek, 2012
Newly detected genetic risk factor for body weight is the FTO gene ("fat mass and obesity associated
[Polymorphism rs9939609 of FTO gene is related to the body mass index in children from Podlaskie voievodship].
GeneRIF
Bossowski et al., Białystok, Poland. In Med Wieku Rozwoj, 2012
Our results demonstrate that rs9939609 FTO gene polymorphism is related to the body mass index in children.
Variant in the FTO gene and biomarkers related to health in mature Slovak women.
GeneRIF
Michnová et al., Bratislava, Slovakia. In Anthropol Anz, 2011
This study demonstrates that the SNP rs178 17449 in the FTO gene is associated with systolic and diastolic blood pressure but not with BMI and obesity variables.
Knockdown of the fat mass and obesity gene disrupts cellular energy balance in a cell-type specific manner.
GeneRIF
Puri et al., Rockford, United States. In Plos One, 2011
These results provide important evidence that FTO-variant linked obesity may be associated with altered metabolic functions through activation of downstream metabolic mediators.
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