A short evolutionary history of FSH-stimulated spermatogenesis.
In Hormones (athens), Feb 2016
The role of the other gonadotrophin, follicle-stimulating hormone (FSH), is as yet somewhat unclear given that several clinical conditions and experimental models, including men with inactivating FSH receptor (R) mutation and male Fshb and Fshrknockout mice, maintain fairly normal spermatogenesis and fertility.
[FSH and FSHR gene polymorphisms and male infertility: An update].
In Zhonghua Nan Ke Xue, Nov 2015
With the development of DNA sequencing technology, FSH SNPs rs10835638 and FSHR SNPs rs6165, rs6166, and rs1394205 were detected, which might directly affect the expression of FSH and activity of FSHR, resulting in male spermatogenic dysfunction.
Expression of follicle-stimulating hormone receptor in tumor blood vessels.
New York City, United States. In N Engl J Med, 2010
METHODS: We used immunohistochemical and immunoblotting techniques involving four separate FSH-receptor-specific monoclonal antibodies that recognize different FSH receptor epitopes and in situ hybridization to detect FSH receptor in tissue samples from patients with a wide range of tumors.
FSH directly regulates bone mass.
New York City, United States. In Cell, 2006
Neither FSHbeta nor FSH receptor (FSHR) null mice have bone loss despite severe hypogonadism.