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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Follicle stimulating hormone receptor

FSHR, FSH receptor, follicle-stimulating hormone receptor, follitropin receptor
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: FSH, CAN, HAD, AGE, V1a
Papers using FSHR antibodies
Brain aging modulates the neuroprotective effects of estrogen on selective aspects of cognition in women: a critical review
Supplier
Maysinger Dusica et al., In Journal of Aging Research, 2007
... Fshr+/− males and females [3, 4] and were then crossed with double transgenic females (C3HeJ x C57BL/6J F1 ...
Papers on FSHR
Combined assessment of polymorphisms in the LHCGR and FSHR genes predict chance of pregnancy after in vitro fertilization.
New
Giwercman et al., Malmö, Sweden. In Hum Reprod, Feb 2016
SUMMARY ANSWER: The luteinizing hormone/human chorionic gonadotrophin receptor (LHCGR) variant N312S and the follicle-stimulating hormone receptor (FSHR) variant N680S can be utilized for the prediction of pregnancy chances in women undergoing IVF.
Polymorphisms in NR5A2, gene encoding Liver Receptor Homolog-1 are associated with Preterm Birth.
New
Murray et al., Buenos Aires, Argentina. In Pediatr Res, Feb 2016
METHODS: Genotyping was performed for 24 single nucleotide polymorphisms (SNPs) in 4 candidate genes (NR5A2, FSHR, FOXP3, SERPINH1).
A short evolutionary history of FSH-stimulated spermatogenesis.
Review
New
Huhtaniemi, In Hormones (athens), Feb 2016
The role of the other gonadotrophin, follicle-stimulating hormone (FSH), is as yet somewhat unclear given that several clinical conditions and experimental models, including men with inactivating FSH receptor (R) mutation and male Fshb and Fshrknockout mice, maintain fairly normal spermatogenesis and fertility.
Ectopic expression of follicle-stimulating hormone receptors in thyroid tumors.
New
Winczyk et al., Łódź, Poland. In Arch Med Sci, Jan 2016
INTRODUCTION: In normal conditions follicle-stimulating hormone receptors (FSHR) are expressed in the ovary and the testis.
Follicle-stimulating hormone-induced rescue of cumulus cell apoptosis and enhanced development ability of buffalo oocytes.
New
Datta et al., Karnāl, India. In Domest Anim Endocrinol, Dec 2015
Significant increase in the expression of FSH receptor messenger RNA was also found with 5 and 10-μg/mL FSH (P < 0.05).
[FSH and FSHR gene polymorphisms and male infertility: An update].
Review
New
Huang et al., In Zhonghua Nan Ke Xue, Nov 2015
With the development of DNA sequencing technology, FSH SNPs rs10835638 and FSHR SNPs rs6165, rs6166, and rs1394205 were detected, which might directly affect the expression of FSH and activity of FSHR, resulting in male spermatogenic dysfunction.
Mechanisms of Action of TSHR Autoantibodies.
Review
New
Rees Smith et al., Cardiff, United Kingdom. In Horm Metab Res, Sep 2015
Similar activation mechanisms seem to take place in the case of FSH and the FSHR and LH and the LHR.
Development of Follicle-Stimulating Hormone Receptor Binding Probes to Image Ovarian Xenografts.
New
Stantz et al., West Lafayette, United States. In J Biotechnol Biomater, Sep 2015
UNASSIGNED: The Follicle-Stimulating Hormone Receptor (FSHR) is used as an imaging biomarker for the detection of ovarian cancer (OC).
Discovery and Development of Small Molecule Allosteric Modulators of Glycoprotein Hormone Receptors.
Review
Palmer et al., Burlington, United States. In Front Endocrinol (lausanne), 2014
FSH receptor (FSHR) and LH receptor are primarily expressed in somatic cells in ovary and testis to promote egg and sperm production in women and men, respectively.
Role of the Extracellular and Intracellular Loops of Follicle-Stimulating Hormone Receptor in Its Function.
Review
Mahale et al., Mumbai, India. In Front Endocrinol (lausanne), 2014
Follicle-stimulating hormone receptor (FSHR) is a leucine-rich repeat containing class A G-protein coupled receptor belonging to the subfamily of glycoprotein hormone receptors (GPHRs), which includes luteinizing hormone/choriogonadotropin receptor (LH/CGR) and thyroid-stimulating hormone receptor.
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
Impact
Chen et al., Shanghai, China. In Nat Genet, 2012
20q13.2 and a second independent signal at 2p16.3 (the FSHR gene).
Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor.
GeneRIF
He et al., Billerica, United States. In Proc Natl Acad Sci U S A, 2012
FSH first binds to the high-affinity hormone-binding subdomain of FSHR and reshapes the ligand conformation to form a sTyr-binding pocket.
Variants in follicle-stimulating hormone receptor gene in infertile Brazilian men and the correlation to FSH serum levels and sperm count.
GeneRIF
Bianco et al., Santo André, Brazil. In Reprod Sci, 2012
genetic association studies in a population of Brazilian men: Data suggest that SNPs in FSHR gene (rs6166/Asn680Ser; rs6165/Thr307Ala) are not correlated with serum FSH (follicle stimulating hormone) levels or sperm count in male infertility.
Regulation of FSH receptor expression by the Wilms' tumor 1 gene product (WT1) in immature rat granulosa cells.
GeneRIF
Roh et al., In Mol Reprod Dev, 2012
report of inhibition of FSHR expression by WT1 in ovarian tissue; inhibition probably occurs via direct interaction with the FSHR promoter
PCOS and peripheral AMH levels in relation to FSH receptor gene single nucleotide polymorphisms.
GeneRIF
Nardo et al., Manchester, United Kingdom. In Gynecol Endocrinol, 2012
no evidence that p.Asn680Ser genotypes associated with polycystic ovary syndrome or high anti-mullerian hormone levels
Molecular pathogenesis of granulosa cell tumors of the ovary.
Review
Impact
Fuller et al., Australia. In Endocr Rev, 2012
To date, many investigations have centered around pathways known to be involved in normal granulosa cell proliferation, including those activated by FSH receptor stimulation.
Testicular development in mice lacking receptors for follicle stimulating hormone and androgen.
GeneRIF
Abel et al., Glasgow, United Kingdom. In Plos One, 2011
By day 20 and in adult animals total AR or FSHR ablation significantly reduced Leydig cell numbers but Sertoli cell specific AR ablation had no effect.
Expression of follicle-stimulating hormone receptor in tumor blood vessels.
Impact
Ghinea et al., New York City, United States. In N Engl J Med, 2010
METHODS: We used immunohistochemical and immunoblotting techniques involving four separate FSH-receptor-specific monoclonal antibodies that recognize different FSH receptor epitopes and in situ hybridization to detect FSH receptor in tissue samples from patients with a wide range of tumors.
Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms.
Review
Impact
Krause et al., Berlin, Germany. In Endocr Rev, 2009
The TSH receptor (TSHR) together with the homologous lutropin/choriogonadotropin receptor and the follitropin receptor are glycoprotein hormone receptors (GPHRs).
FSH directly regulates bone mass.
Impact
Zaidi et al., New York City, United States. In Cell, 2006
Neither FSHbeta nor FSH receptor (FSHR) null mice have bone loss despite severe hypogonadism.
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