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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Bromodomain containing 2

FSH
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: HAD, AGE, CAN, FSHR, Gonadotropin-Releasing Hormone
Papers using FSH antibodies
Analysis of the testicular phenotype of the follicle-stimulating hormone beta-subunit knockout and the activin type II receptor knockout mice by stereological analysis
Supplier
O'Shaughnessy P J et al., In Journal of Molecular Endocrinology, 2000
... of age and in group sizes of 3–4, were injected subcutaneously with 8 IU recombinant human FSH (rhFSH) (Serono Ltd) in 0·2 ml PBS (PBS, pH 7·4, Sigma Aldrich) at the start of ...
Papers on FSH
Argirein alleviates stress-induced and diabetic hypogonadism in rats via normalizing testis endothelin receptor A and connexin 43.
New
Dai et al., Nanjing, China. In Acta Pharmacol Sin, Feb 2016
RESULTS: ISO injection induced hyper-gonadotrophic hypogonadism characterized by low testosterone and high FSH and LH levels in the serum, whereas STZ injection induced hypo-gonadotrophic hypogonadism as evidenced by low testosterone and low FSH and LH levels in the serum.
The endocannabinoid system in the human granulosa cell line KGN.
New
Dehghani et al., Halle, Germany. In Mol Cell Endocrinol, Feb 2016
In the present study we characterized the ECS in the human granulosa cell line KGN and its impact on gonadotropin sensitivity and steroid hormone synthesis under basal and FSH- stimulated conditions.
G-protein-coupled estrogen receptor-30 gene polymorphisms are associated with uterine leiomyoma risk.
New
Öner et al., Muğla, Turkey. In Bosn J Basic Med Sci, Feb 2016
To understand the relationship between GPR30 single nucleotide polymorphisms and the risk of leiomyoma, we measured the follicle-stimulating hormone (FSH) and estradiol (E2) levels of 78 perimenopausal healthy women and 111 perimenopausal women with leiomyomas.
The Sertoli cell as the orchestra conductor of spermatogenesis: spermatogenic cells dance to the tune of testosterone.
Review
New
Sofikitis et al., In Hormones (athens), Feb 2016
Moreover, receptors for follicle stimulating hormone (FSH) and testosterone, which are the main hormonal regulators of spermatogenesis, are identified on SCs.
A short evolutionary history of FSH-stimulated spermatogenesis.
Review
New
Huhtaniemi, In Hormones (athens), Feb 2016
The role of the other gonadotrophin, follicle-stimulating hormone (FSH), is as yet somewhat unclear given that several clinical conditions and experimental models, including men with inactivating FSH receptor (R) mutation and male Fshb and Fshrknockout mice, maintain fairly normal spermatogenesis and fertility.
Functional role of the heterodimeric glycoprotein hormone, GPA2/GPB5, and its receptor, LGR1: an invertebrate perspective.
Review
New
Paluzzi et al., Toronto, Canada. In Gen Comp Endocrinol, Jan 2016
UNASSIGNED: In vertebrates, follicle-stimulating hormone (FSH), luteinizing hormone (LH), chorionic gonadotropin (CG) and thyroid-stimulating hormone (TSH) are glycoprotein hormones that play central roles in metabolism, reproduction and development.
Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men.
Review
New
de Jongh et al., Amsterdam, Netherlands. In J Steroid Biochem Mol Biol, Dec 2015
Outcome measures were total testosterone, calculated bioavailable and free fraction testosterone, SHBG, estradiol, LH and FSH concentrations.
Follicle-stimulating hormone-induced rescue of cumulus cell apoptosis and enhanced development ability of buffalo oocytes.
New
Datta et al., Karnāl, India. In Domest Anim Endocrinol, Dec 2015
UNASSIGNED: The effect of follicle-stimulating hormone (FSH) on apoptotic status of cumulus cells, expression of proapoptotic and antiapoptotic genes, and development rate of in vitro fertilization-produced buffalo embryos were investigated.
[FSH and FSHR gene polymorphisms and male infertility: An update].
Review
New
Huang et al., In Zhonghua Nan Ke Xue, Nov 2015
Follicle-stimulating hormone (FSH) is synthesized and secreted by the anterior pituitary, which binds to its receptors expressed on the membrane of Sertoli cells in the testis to bring about spermatogenesis.
Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy.
New
Impact
POEMS/S0230 Investigators et al., Sydney, Australia. In N Engl J Med, Apr 2015
The primary study end point was the rate of ovarian failure at 2 years, with ovarian failure defined as the absence of menses in the preceding 6 months and levels of follicle-stimulating hormone (FSH) in the postmenopausal range.
Intraovarian control of early folliculogenesis.
Review
New
Impact
Fauser et al., Kawasaki, Japan. In Endocr Rev, Feb 2015
Although hormonal regulation of ovarian follicle development has been extensively investigated, most studies concentrate on the development of early antral follicles to the preovulatory stage, leading to the successful use of exogenous FSH for infertility treatment.
Effect of transcription factor ZBTB20 on mouse pituitary development.
Li et al., Tai'an, China. In Genet Mol Res, 2014
Real-time polymerase chain reaction and western blotting assays were used to detect the levels of five hormones: growth hormone (GH), prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH).
Inhibin at 90: from discovery to clinical application, a historical review.
Review
Impact
Woodruff et al., Evanston, United States. In Endocr Rev, 2014
Ninety years later, what we know about inhibin stretches far beyond its well-established capacity to inhibit activin signaling and suppress pituitary FSH production.
Randomized trial using gonadotropin-releasing hormone agonist triptorelin for the preservation of ovarian function during (neo)adjuvant chemotherapy for breast cancer.
Impact
Minton et al., San Francisco, United States. In J Clin Oncol, 2012
Objectives included the resumption of menses and serial monitoring of follicle-stimulating hormone (FSH) and inhibin A and B levels.
Molecular pathogenesis of granulosa cell tumors of the ovary.
Review
Impact
Fuller et al., Australia. In Endocr Rev, 2012
To date, many investigations have centered around pathways known to be involved in normal granulosa cell proliferation, including those activated by FSH receptor stimulation.
Expression of BET genes in testis of men with different spermatogenic impairments.
GeneRIF
Kleiman et al., Ramat Gan, Israel. In Fertil Steril, 2012
The BRDT gene was not expressed in testicular tissue from patients with Sertoli cells only, whereas the other three genes of the BET family retained expression in all the sperm pathologies.
The bromodomain-containing gene BRD2 is regulated at transcription, splicing, and translation levels.
GeneRIF
Wolgemuth et al., New York City, United States. In J Cell Biochem, 2011
The bromodomain-containing gene BRD2 is regulated at transcription, splicing, and translation levels.
Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2.
GeneRIF
Padmanabhan et al., Yokohama, Japan. In Febs Lett, 2010
the crystal structure of the second bromodomain of BRD2 (BRD2-BD2) in complex with the di-acetylated histone H4 tail (H4K5ac/K12ac) was shown.
Structural basis for acetylated histone H4 recognition by the human BRD2 bromodomain.
GeneRIF
Yokoyama et al., Yokohama, Japan. In J Biol Chem, 2010
Data report the crystal structures of the N-terminal bromodomain of human BRD2 (BRD2-BD1; residues 74-194) in complex with each of three different Lys-12-acetylated histone H4 peptides.
WHAT do viruses BET on?
GeneRIF
Schulz et al., Hannover, Germany. In Front Biosci, 2009
Studies indicate that KSHV LANA interacts with Brd2 and Brd4.
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