A short evolutionary history of FSH-stimulated spermatogenesis.
In Hormones (athens), Feb 2016
The role of the other gonadotrophin, follicle-stimulating hormone (FSH), is as yet somewhat unclear given that several clinical conditions and experimental models, including men with inactivating FSH receptor (R) mutation and male Fshb and Fshrknockout mice, maintain fairly normal spermatogenesis and fertility.
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Liège, Belgium. In Front Endocrinol (lausanne), 2013
Interestingly, defects in PROKR2, FGFR1, FGF8, CHD7, DUSP6, and WDR11 genes are also associated with normosmic IHH, whereas mutations in KISS1/KISSR, TAC3/TACR3, GNRH1/GNRHR, LEP/LEPR, HESX1, FSHB, and LHB are only present in patients with normosmic IHH.
FSH directly regulates bone mass.
New York City, United States. In Cell, 2006
Neither FSHbeta nor FSH receptor (FSHR) null mice have bone loss despite severe hypogonadism.