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Follicle stimulating hormone, beta polypeptide

FSH beta, FSHB
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FSH, Gonadotropin-Releasing Hormone, HAD, CD45, ACID
Papers on FSH beta
Bone morphogenetic protein 2 stimulates noncanonical SMAD2/3 signaling via the BMP type 1A receptor in gonadotrope-like cells: implications for FSH synthesis.
Bernard et al., Montréal, Canada. In Endocrinology, May 2014
Activins stimulate FSH synthesis via transcriptional regulation of its β-subunit gene (Fshb).
Mechanisms in endocrinology: Genetics of FSH action: a 2014-and-beyond view.
Casarini et al., Modena, Italy. In Eur J Endocrinol, Mar 2014
METHODS: Single-nucleotide polymorphism (SNP) assessed: rs6166 (c.2039A>G, p.N680S), rs6165 (c.919A>G, p.T307A), rs1394205 (c.-29G>A) in FSHR, and rs10835638 (c.-211G>T) in FSHB.
Effects of diethylstilbestrol on luteinizing hormone-producing cells in the mouse anterior pituitary.
Sato et al., Yokohama, Japan. In Exp Biol Med (maywood), Mar 2014
Ovariectomy increased the expression of the alpha subunit of glycoprotein hormones, FSH beta (Fshb) subunit and Lhb subunit both in neoOil and neoDES females, suggesting that the anterior pituitary of neoDES female mice is regulated by ovarian hormones via negative feedback.
Follicle-stimulating hormone synthesis and fertility are intact in mice lacking SMAD3 DNA binding activity and SMAD2 in gonadotrope cells.
Bernard et al., Montréal, Canada. In Faseb J, Mar 2014
In vitro cell line data suggest that activins stimulate FSH β-subunit (Fshb) transcription via complexes containing the receptor-regulated SMAD proteins SMAD2 and SMAD3.
Transcriptome profiling identifies differentially expressed genes in postnatal developing pituitary gland of miniature pig.
Li et al., Beijing, China. In Dna Res, Dec 2013
Four hormone genes (GH, PRL, LHB, and FSHB) were detected in all samples with extremely high levels of expression.
The molecular basis of impaired follicle-stimulating hormone action: evidence from human mutations and mouse models.
Layman et al., Augusta, United States. In Reprod Sci, Mar 2013
Knockout mice for both the ligand (Fshb) and the receptor (Fshr) serve as models for FSH deficiency, while Fshb and Fshr transgenic mice manifest FSH excess.
Mechanisms of activin-stimulated FSH synthesis: the story of a pig and a FOX.
Tran et al., Montréal, Canada. In Biol Reprod, Mar 2013
In this minireview, we chronicle the research that led to the recent discovery of forkhead box L2 (FOXL2) as an essential mediator of activin-regulated FSH beta subunit (Fshb) transcription in vitro and in vivo.
Possible role of PACAP and its PAC1 receptor in the differential regulation of pituitary LHbeta- and FSHbeta-subunit gene expression by pulsatile GnRH stimulation.
Miyazaki et al., Izumo, Japan. In Biol Reprod, Feb 2013
PACAP stimulates gonadotropin alpha-, LHbeta-, and FSHbeta-subunits as well as receptors for GnRH in the pituitary gonadotropin-secreting cells.
The effect of induced anti-follicle-stimulating hormone autoantibody on serum hormone level and apoptosis in rat testis.
Xia et al., Nanjing, China. In Life Sci, 2012
FSH autoantibody could cause the reduction of inhibin B, thereby inducing hypospermatogenesis via augment of spermatogenic cell apoptosis
Pharmacogenetics of follicle-stimulating hormone action.
Huhtaniemi et al., Tartu, Estonia. In Curr Opin Endocrinol Diabetes Obes, 2012
PURPOSE OF REVIEW: To review the current knowledge of genetic variants in the two genes affecting the individual responsiveness to follicle-stimulating hormone (FSH) action-the FSH beta-subunit (FSHB) and the FSH receptor (FSHR), as well as the pharmacogenetic ramifications of the findings.
FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoter.
Thackray et al., San Diego, United States. In Endocrinology, 2012
Protein-protein interactions among FOXL2, SMAD3, and progesterone receptor (PR) recruited to the Fshb promoter play a key role in facilitating Fshb transcription before the secondary FSH surge in rodents.
Decreased bone mineral density in rats rendered follicle-deplete by an ovotoxic chemical correlates with changes in follicle-stimulating hormone and inhibin A.
Funk et al., Tucson, United States. In Calcif Tissue Int, 2012
Both the hormonal milieu of perimenopause and the association of dynamic perimenopausal changes in FSH and inhibin A with decreased bone mineral density have been reproduced in an animal model.
The effects of FSH and activin A on follicle development in vitro.
Drummond et al., Australia. In Reproduction, 2012
Novel findings supporting the role of FSH in primordial follicle survival through an action on apoptosis.
Toward a pharmacogenetic approach to male infertility: polymorphism of follicle-stimulating hormone beta-subunit promoter.
Foresta et al., Padova, Italy. In Fertil Steril, 2011
FSHB -211 TT genotype might represent a novel treatable form of male infertility characterized by severe spermatogenic impairment and low or inappropriately normal FSH plasma levels.
PACAP, an autocrine/paracrine regulator of gonadotrophs.
Moore et al., Louisville, United States. In Biol Reprod, 2011
PACAP increases alpha-subunit (Cga) and Lhb mRNAs, and it stimulates the transcription of follistatin (Fst) that, in turn, restrains activin signaling to repress Fshb and gonadotropin-releasing hormone-receptor (Gnrhr) expression as well as other activin-responsive genes.
FSH directly regulates bone mass.
Zaidi et al., New York City, United States. In Cell, 2006
Neither FSHbeta nor FSH receptor (FSHR) null mice have bone loss despite severe hypogonadism.
The functional significance of FSH in spermatogenesis and the control of its secretion in male primates.
Marshall et al., Pittsburgh, United States. In Endocr Rev, 2001
Inhibin B is the major component of the testicular negative feedback signal governing FSH beta gene expression and FSH secretion, and the evidence for this view is presented.
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility.
Matzuk et al., Houston, United States. In Nat Genet, 1997
Minimal data has been accumulated so far involving human mutations in the FSH beta, LH beta, or the gonadotropin receptor genes.
Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1).
Milbrandt et al., Saint Louis, United States. In Science, 1996
Ovariectomy led to increased amounts of FSH-beta but not LH-beta messenger RNA, which suggested a pituitary defect.
Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone.
Chatterjee et al., Cambridge, United Kingdom. In Nat Genet, 1993
Sequence analysis of the FSH beta-subunit gene indicated that she is homozygous for a two nucleotide frameshift deletion in the coding sequence.
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