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Follicle stimulating hormone, beta polypeptide

FSH beta, FSHB
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FSH, Gonadotropin-Releasing Hormone, HAD, CD45, ACID
Papers on FSH beta
Follicle-stimulating hormone regulates expression and activity of epidermal growth factor receptor in the murine ovarian follicle.
Clarke et al., Brussels, Belgium. In Proc Natl Acad Sci U S A, 10 Dec 2014
We show that follicles of Fshb(-/-) mice, which cannot produce FSH, have a severely impaired ability to support two essential EGFR-regulated events: expansion of the cumulus granulosa cell layer that encloses the oocyte and meiotic maturation of the oocyte.
Aromatase (Cyp19a1b) in the Pituitary Is Dynamically Involved in the Upregulation of lhb But Not fshb in the Vitellogenic Female Ricefield Eel Monopterus albus.
Zhang et al., Guangzhou, China. In Endocrinology, 30 Nov 2014
Our present study demonstrated that Cyp19a1b is colocalized with Lhb, but not Fshb, during vitellogenesis in female ricefield eels.
β-catenin stabilization in gonadotropes impairs follicle-stimulating hormone synthesis in male mice in vivo.
Bernard et al., Montréal, Canada. In Endocrinology, 24 Nov 2014
UNLABELLED: Though classically considered a WNT signaling intermediary, CTNNB1 (β-catenin) can also mediate GnRH induction of gonadotropin β subunit (Fshb and Lhb) transcription in the murine gonadotrope-like cell line LβT2.
A time-course transcriptional kinetics of the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes in zebrafish eleuthero-embryos after exposure to norgestrel.
Peng et al., Guangzhou, China. In Environ Toxicol Chem, 15 Nov 2014
The transcriptional expression levels of Esr1, Ar, Star, Hsd17b3, Fshb, and Pomc were also mediated by 5 ng L(-1) NGT or higher during different exposure periods.
Identification of human prolactinoma related genes by DNA microarray.
Wang et al., Fuzhou, China. In J Cancer Res Ther, Jul 2014
Two down-regulated genes, FSHB (follicle stimulating hormone β subunit) and LHB (luteinizing hormone β subunit) were involved in GnRH (gonadotropin-releasing hormone) signaling pathway.
Mechanisms in endocrinology: Genetics of FSH action: a 2014-and-beyond view.
Casarini et al., Modena, Italy. In Eur J Endocrinol, Mar 2014
METHODS: Single-nucleotide polymorphism (SNP) assessed: rs6166 (c.2039A>G, p.N680S), rs6165 (c.919A>G, p.T307A), rs1394205 (c.-29G>A) in FSHR, and rs10835638 (c.-211G>T) in FSHB.
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Beckers et al., Liège, Belgium. In Front Endocrinol (lausanne), Dec 2013
Interestingly, defects in PROKR2, FGFR1, FGF8, CHD7, DUSP6, and WDR11 genes are also associated with normosmic IHH, whereas mutations in KISS1/KISSR, TAC3/TACR3, GNRH1/GNRHR, LEP/LEPR, HESX1, FSHB, and LHB are only present in patients with normosmic IHH.
Mechanisms of activin-stimulated FSH synthesis: the story of a pig and a FOX.
Tran et al., Montréal, Canada. In Biol Reprod, Mar 2013
In this minireview, we chronicle the research that led to the recent discovery of forkhead box L2 (FOXL2) as an essential mediator of activin-regulated FSH beta subunit (Fshb) transcription in vitro and in vivo.
The molecular basis of impaired follicle-stimulating hormone action: evidence from human mutations and mouse models.
Layman et al., Augusta, United States. In Reprod Sci, Mar 2013
Knockout mice for both the ligand (Fshb) and the receptor (Fshr) serve as models for FSH deficiency, while Fshb and Fshr transgenic mice manifest FSH excess.
Possible role of PACAP and its PAC1 receptor in the differential regulation of pituitary LHbeta- and FSHbeta-subunit gene expression by pulsatile GnRH stimulation.
Miyazaki et al., Izumo, Japan. In Biol Reprod, Feb 2013
PACAP stimulates gonadotropin alpha-, LHbeta-, and FSHbeta-subunits as well as receptors for GnRH in the pituitary gonadotropin-secreting cells.
The effect of induced anti-follicle-stimulating hormone autoantibody on serum hormone level and apoptosis in rat testis.
Xia et al., Nanjing, China. In Life Sci, 2012
FSH autoantibody could cause the reduction of inhibin B, thereby inducing hypospermatogenesis via augment of spermatogenic cell apoptosis
FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoter.
Thackray et al., San Diego, United States. In Endocrinology, 2012
Protein-protein interactions among FOXL2, SMAD3, and progesterone receptor (PR) recruited to the Fshb promoter play a key role in facilitating Fshb transcription before the secondary FSH surge in rodents.
Decreased bone mineral density in rats rendered follicle-deplete by an ovotoxic chemical correlates with changes in follicle-stimulating hormone and inhibin A.
Funk et al., Tucson, United States. In Calcif Tissue Int, 2012
Both the hormonal milieu of perimenopause and the association of dynamic perimenopausal changes in FSH and inhibin A with decreased bone mineral density have been reproduced in an animal model.
The effects of FSH and activin A on follicle development in vitro.
Drummond et al., Australia. In Reproduction, 2012
Novel findings supporting the role of FSH in primordial follicle survival through an action on apoptosis.
Toward a pharmacogenetic approach to male infertility: polymorphism of follicle-stimulating hormone beta-subunit promoter.
Foresta et al., Padova, Italy. In Fertil Steril, 2011
FSHB -211 TT genotype might represent a novel treatable form of male infertility characterized by severe spermatogenic impairment and low or inappropriately normal FSH plasma levels.
FSH directly regulates bone mass.
Zaidi et al., New York City, United States. In Cell, 2006
Neither FSHbeta nor FSH receptor (FSHR) null mice have bone loss despite severe hypogonadism.
The functional significance of FSH in spermatogenesis and the control of its secretion in male primates.
Marshall et al., Pittsburgh, United States. In Endocr Rev, 2001
Inhibin B is the major component of the testicular negative feedback signal governing FSH beta gene expression and FSH secretion, and the evidence for this view is presented.
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility.
Matzuk et al., Houston, United States. In Nat Genet, 1997
Minimal data has been accumulated so far involving human mutations in the FSH beta, LH beta, or the gonadotropin receptor genes.
Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1).
Milbrandt et al., Saint Louis, United States. In Science, 1996
Ovariectomy led to increased amounts of FSH-beta but not LH-beta messenger RNA, which suggested a pituitary defect.
Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone.
Chatterjee et al., Cambridge, United Kingdom. In Nat Genet, 1993
Sequence analysis of the FSH beta-subunit gene indicated that she is homozygous for a two nucleotide frameshift deletion in the coding sequence.
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