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Follicle stimulating hormone, beta polypeptide

FSH beta, FSHB
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FSH, Gonadotropin-Releasing Hormone, HAD, CD45, ACID
Papers on FSH beta
Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.
New
Murray et al., Exeter, United Kingdom. In Hum Reprod, Feb 2016
STUDY QUESTION: How does a genetic variant in the FSHB promoter, known to alter FSH levels, impact female reproductive health?
Icam5 expression exhibits sex differences in the neonatal pituitary and is regulated by estradiol and bisphenol A.
New
Raetzman et al., Urbana, United States. In Endocrinology, Feb 2016
Through microarray and qRT-PCR analysis of pituitaries at PND1, three genes were differentially expressed between males and females: Lhb, Fshb, and intracellular adhesion molecule-5 (Icam5).
A short evolutionary history of FSH-stimulated spermatogenesis.
Review
New
Huhtaniemi, In Hormones (athens), Feb 2016
The role of the other gonadotrophin, follicle-stimulating hormone (FSH), is as yet somewhat unclear given that several clinical conditions and experimental models, including men with inactivating FSH receptor (R) mutation and male Fshb and Fshrknockout mice, maintain fairly normal spermatogenesis and fertility.
Fshb-iCre mice are efficient and specific Cre deleters for the gonadotrope lineage.
New
Kumar et al., Raleigh, United States. In Mol Cell Endocrinol, Feb 2016
Here, we describe generation and characterization of a new Fshb-iCre deleter strain using 4.7 kb of ovine Fshb promoter regulatory sequences driving iCre expression exclusively in the gonadotrope lineage within anterior pituitary.
Naturally occurring genetic mutations in the 5'-upstream regulatory region of bovine FSHB generate a novel cis-regulatory element that affects its expression.
New
Zhang et al., Changchun, China. In Anim Genet, Dec 2015
We previously reported that numerous naturally occurring genetic mutations in the 5'-upstream regulatory region (5'-URR) of the bovine follicle-stimulating hormone beta-subunit gene (FSHB) were associated with reduced serum follicle-stimulating hormone (FSH) levels, poor-quality semen and low fertility in bulls.
Minireview: Activin Signaling in Gonadotropes: What Does the FOX say… to the SMAD?
Review
New
Bernard et al., Toronto, Canada. In Mol Endocrinol, Jul 2015
The activins were discovered and named based on their abilities to stimulate FSH secretion and FSHβ (Fshb) subunit expression by pituitary gonadotrope cells.
Genetic variants in the upstream region of activin receptor IIA are associated with female fertility in Japanese Black cattle.
Sugimoto et al., Fukushima, Japan. In Bmc Genet, 2014
Expression of exogenous ACVR2A induced dose-dependent increases of reporter activity from the follicle-stimulating hormone, beta polypeptide (FSHB) promoter in response to activin A in a pituitary gonadotrophic cell line.
Mechanisms in endocrinology: Genetics of FSH action: a 2014-and-beyond view.
Review
Casarini et al., Modena, Italy. In Eur J Endocrinol, 2014
METHODS: Single-nucleotide polymorphism (SNP) assessed: rs6166 (c.2039A>G, p.N680S), rs6165 (c.919A>G, p.T307A), rs1394205 (c.-29G>A) in FSHR, and rs10835638 (c.-211G>T) in FSHB.
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Review
Beckers et al., Liège, Belgium. In Front Endocrinol (lausanne), 2013
Interestingly, defects in PROKR2, FGFR1, FGF8, CHD7, DUSP6, and WDR11 genes are also associated with normosmic IHH, whereas mutations in KISS1/KISSR, TAC3/TACR3, GNRH1/GNRHR, LEP/LEPR, HESX1, FSHB, and LHB are only present in patients with normosmic IHH.
Mechanisms of activin-stimulated FSH synthesis: the story of a pig and a FOX.
Review
Tran et al., Montréal, Canada. In Biol Reprod, 2013
In this minireview, we chronicle the research that led to the recent discovery of forkhead box L2 (FOXL2) as an essential mediator of activin-regulated FSH beta subunit (Fshb) transcription in vitro and in vivo.
The effect of induced anti-follicle-stimulating hormone autoantibody on serum hormone level and apoptosis in rat testis.
GeneRIF
Xia et al., Nanjing, China. In Life Sci, 2012
FSH autoantibody could cause the reduction of inhibin B, thereby inducing hypospermatogenesis via augment of spermatogenic cell apoptosis
FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoter.
GeneRIF
Thackray et al., San Diego, United States. In Endocrinology, 2012
Protein-protein interactions among FOXL2, SMAD3, and progesterone receptor (PR) recruited to the Fshb promoter play a key role in facilitating Fshb transcription before the secondary FSH surge in rodents.
Decreased bone mineral density in rats rendered follicle-deplete by an ovotoxic chemical correlates with changes in follicle-stimulating hormone and inhibin A.
GeneRIF
Funk et al., Tucson, United States. In Calcif Tissue Int, 2012
Both the hormonal milieu of perimenopause and the association of dynamic perimenopausal changes in FSH and inhibin A with decreased bone mineral density have been reproduced in an animal model.
The effects of FSH and activin A on follicle development in vitro.
GeneRIF
Drummond et al., Australia. In Reproduction, 2012
Novel findings supporting the role of FSH in primordial follicle survival through an action on apoptosis.
Toward a pharmacogenetic approach to male infertility: polymorphism of follicle-stimulating hormone beta-subunit promoter.
GeneRIF
Foresta et al., Padova, Italy. In Fertil Steril, 2011
FSHB -211 TT genotype might represent a novel treatable form of male infertility characterized by severe spermatogenic impairment and low or inappropriately normal FSH plasma levels.
FSH directly regulates bone mass.
Impact
Zaidi et al., New York City, United States. In Cell, 2006
Neither FSHbeta nor FSH receptor (FSHR) null mice have bone loss despite severe hypogonadism.
The functional significance of FSH in spermatogenesis and the control of its secretion in male primates.
Review
Impact
Marshall et al., Pittsburgh, United States. In Endocr Rev, 2001
Inhibin B is the major component of the testicular negative feedback signal governing FSH beta gene expression and FSH secretion, and the evidence for this view is presented.
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility.
Impact
Matzuk et al., Houston, United States. In Nat Genet, 1997
Minimal data has been accumulated so far involving human mutations in the FSH beta, LH beta, or the gonadotropin receptor genes.
Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1).
Impact
Milbrandt et al., Saint Louis, United States. In Science, 1996
Ovariectomy led to increased amounts of FSH-beta but not LH-beta messenger RNA, which suggested a pituitary defect.
Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone.
Impact
Chatterjee et al., Cambridge, United Kingdom. In Nat Genet, 1993
Sequence analysis of the FSH beta-subunit gene indicated that she is homozygous for a two nucleotide frameshift deletion in the coding sequence.
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