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Follicle stimulating hormone, beta polypeptide

FSH beta, FSHB
The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FSH, Gonadotropin-Releasing Hormone, HAD, CD45, ACID
Papers on FSH beta
Distinct functions of neuromedin u and neuromedin s in orange-spotted grouper.
New
Lin et al., Zhanjiang, China. In J Mol Endocrinol, 31 Oct 2015
Furthermore, the mRNA levels of LH beta subunit (lhβ) and gh in the pituitary were significantly down-regulated after Nmu-21 peptide administration, while Nmsrp was able to significantly stimulate the expression of FSH beta subunit (fshβ), prolactin (prl), and somatolaction (sl).
A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice.
New
Mellon et al., In Biol Reprod, 22 Aug 2015
In contrast, serum FSH and Fshb were significantly reduced in LET females, demonstrating differential effects on gonadotropins, as in PCOS.
Cell Type-Specific Sexual Dimorphism in Rat Pituitary Gene Expression During Maturation.
New
Stojilkovic et al., Bethesda, United States. In Biol Reprod, 31 Jul 2015
Gonadotrophs exhibit highly synchronized Lhb, Fshb, Cga, and Gnrhr expression in both sexes, but the peak of expression occurs during the infantile period in females and at the end of the juvenile period in males.
Comparative Anterior Pituitary miRNA and mRNA Expression Profiles of Bama Minipigs and Landrace Pigs Reveal Potential Molecular Network Involved in Animal Postnatal Growth.
New
Zhang et al., Guangzhou, China. In Plos One, Dec 2014
Among them, two miRNA-mRNA interactions (Y-47 targets FSHB; ssc-miR-133a-3p targets GNAI3) were validated by dual-luciferase assay.
Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.
New
Dunaif et al., Chicago, United States. In Nat Commun, Dec 2014
The same chr 11p14.1 SNP, rs11031006, in the region of the follicle-stimulating hormone B polypeptide (FSHB) gene strongly associates with PCOS diagnosis and luteinizing hormone levels.
Mechanisms in endocrinology: Genetics of FSH action: a 2014-and-beyond view.
Review
New
Casarini et al., Modena, Italy. In Eur J Endocrinol, Mar 2014
METHODS: Single-nucleotide polymorphism (SNP) assessed: rs6166 (c.2039A>G, p.N680S), rs6165 (c.919A>G, p.T307A), rs1394205 (c.-29G>A) in FSHR, and rs10835638 (c.-211G>T) in FSHB.
Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.
Review
Beckers et al., Liège, Belgium. In Front Endocrinol (lausanne), 2013
Interestingly, defects in PROKR2, FGFR1, FGF8, CHD7, DUSP6, and WDR11 genes are also associated with normosmic IHH, whereas mutations in KISS1/KISSR, TAC3/TACR3, GNRH1/GNRHR, LEP/LEPR, HESX1, FSHB, and LHB are only present in patients with normosmic IHH.
Mechanisms of activin-stimulated FSH synthesis: the story of a pig and a FOX.
Review
Tran et al., Montréal, Canada. In Biol Reprod, 2013
In this minireview, we chronicle the research that led to the recent discovery of forkhead box L2 (FOXL2) as an essential mediator of activin-regulated FSH beta subunit (Fshb) transcription in vitro and in vivo.
The molecular basis of impaired follicle-stimulating hormone action: evidence from human mutations and mouse models.
Review
Layman et al., Augusta, United States. In Reprod Sci, 2013
Knockout mice for both the ligand (Fshb) and the receptor (Fshr) serve as models for FSH deficiency, while Fshb and Fshr transgenic mice manifest FSH excess.
Possible role of PACAP and its PAC1 receptor in the differential regulation of pituitary LHbeta- and FSHbeta-subunit gene expression by pulsatile GnRH stimulation.
Review
Miyazaki et al., Izumo, Japan. In Biol Reprod, 2013
PACAP stimulates gonadotropin alpha-, LHbeta-, and FSHbeta-subunits as well as receptors for GnRH in the pituitary gonadotropin-secreting cells.
The effect of induced anti-follicle-stimulating hormone autoantibody on serum hormone level and apoptosis in rat testis.
GeneRIF
Xia et al., Nanjing, China. In Life Sci, 2012
FSH autoantibody could cause the reduction of inhibin B, thereby inducing hypospermatogenesis via augment of spermatogenic cell apoptosis
FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoter.
GeneRIF
Thackray et al., San Diego, United States. In Endocrinology, 2012
Protein-protein interactions among FOXL2, SMAD3, and progesterone receptor (PR) recruited to the Fshb promoter play a key role in facilitating Fshb transcription before the secondary FSH surge in rodents.
Decreased bone mineral density in rats rendered follicle-deplete by an ovotoxic chemical correlates with changes in follicle-stimulating hormone and inhibin A.
GeneRIF
Funk et al., Tucson, United States. In Calcif Tissue Int, 2012
Both the hormonal milieu of perimenopause and the association of dynamic perimenopausal changes in FSH and inhibin A with decreased bone mineral density have been reproduced in an animal model.
The effects of FSH and activin A on follicle development in vitro.
GeneRIF
Drummond et al., Australia. In Reproduction, 2012
Novel findings supporting the role of FSH in primordial follicle survival through an action on apoptosis.
Toward a pharmacogenetic approach to male infertility: polymorphism of follicle-stimulating hormone beta-subunit promoter.
GeneRIF
Foresta et al., Padova, Italy. In Fertil Steril, 2011
FSHB -211 TT genotype might represent a novel treatable form of male infertility characterized by severe spermatogenic impairment and low or inappropriately normal FSH plasma levels.
FSH directly regulates bone mass.
Impact
Zaidi et al., New York City, United States. In Cell, 2006
Neither FSHbeta nor FSH receptor (FSHR) null mice have bone loss despite severe hypogonadism.
The functional significance of FSH in spermatogenesis and the control of its secretion in male primates.
Review
Impact
Marshall et al., Pittsburgh, United States. In Endocr Rev, 2001
Inhibin B is the major component of the testicular negative feedback signal governing FSH beta gene expression and FSH secretion, and the evidence for this view is presented.
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility.
Impact
Matzuk et al., Houston, United States. In Nat Genet, 1997
Minimal data has been accumulated so far involving human mutations in the FSH beta, LH beta, or the gonadotropin receptor genes.
Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1).
Impact
Milbrandt et al., Saint Louis, United States. In Science, 1996
Ovariectomy led to increased amounts of FSH-beta but not LH-beta messenger RNA, which suggested a pituitary defect.
Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone.
Impact
Chatterjee et al., Cambridge, United Kingdom. In Nat Genet, 1993
Sequence analysis of the FSH beta-subunit gene indicated that she is homozygous for a two nucleotide frameshift deletion in the coding sequence.
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