Pharmacogenetics of follicle-stimulating hormone action.
Tartu, Estonia. In Curr Opin Endocrinol Diabetes Obes, 2012
PURPOSE OF REVIEW: To review the current knowledge of genetic variants in the two genes affecting the individual responsiveness to follicle-stimulating hormone (FSH) action-the FSH beta-subunit (FSHB) and the FSH receptor (FSHR), as well as the pharmacogenetic ramifications of the findings.
PACAP, an autocrine/paracrine regulator of gonadotrophs.
Louisville, United States. In Biol Reprod, 2011
PACAP increases alpha-subunit (Cga) and Lhb mRNAs, and it stimulates the transcription of follistatin (Fst) that, in turn, restrains activin signaling to repress Fshb and gonadotropin-releasing hormone-receptor (Gnrhr) expression as well as other activin-responsive genes.
FSH directly regulates bone mass.
New York City, United States. In Cell, 2006
Neither FSHbeta nor FSH receptor (FSHR) null mice have bone loss despite severe hypogonadism.