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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zinc finger and BTB domain containing 22

Fru
Encodes a putative transcription factor that regulates iron uptake responses. mRNA is detected in the outer cell layers of the root and accumulates in response to iron deficiency. The expression of many iron-regulated genes is dependent on FIT1. It specifically regulates FRO2 at the level of mRNA accumulation and IRT1 at the level of protein accumulation.Similar to FER in tomato and is a regulator of iron uptake. (from NCBI)
Top mentioned proteins: Phosphofructokinase-1, CAN, ACID, 6-phosphofructo-2-kinase, HAD
Papers on Fru
A Novel Gene Controlling the Timing of Courtship Initiation in Drosophila melanogaster.
New
French et al., San José, Costa Rica. In Genetics, Jan 2016
Courtship behavior is both complex and innate, and a single gene, fruitless (fru), is both necessary and sufficient for all aspects of the courtship ritual.
Neuregulin improves response to glucose tolerance test in control and diabetic rats.
New
Guma et al., Barcelona, Spain. In Am J Physiol Endocrinol Metab, Jan 2016
rNRG also increased the content of fructose-2,6-biphosphate (Fru-2,6-P2), an activator of hepatic glycolysis, and lactate in liver but not in muscle.
Synthesis and inhibitory activity of substrate-analog fructosyl peptide oxidase inhibitors.
New
Kajiyama et al., Uji, Japan. In Bioorg Med Chem Lett, Oct 2015
These inhibitors mimic N(α)-fructosyl-L-valine (Fru-Val), [N(α)-fructosyl-L-valyl]-L-histidine (Fru-ValHis), and N(ε)-fructosyl-L-lysine (εFru-Lys), respectively.
Characterization and physiological role of two types of chloroplastic fructose-1,6-bisphosphatases in Euglena gracilis.
New
Shigeoka et al., Nara, Japan. In Arch Biochem Biophys, Jul 2015
The Km values of recombinant EgFBPaseI and EgFBPaseII for fructose 1,6-bisphosphate (Fru 1,6-P2) were 165 ± 17 and 2200 ± 200 μM, respectively.
Comparison of modification sites in glycated crystallin in vitro and in vivo.
New
Szewczuk et al., Wrocław, Poland. In Anal Bioanal Chem, Mar 2015
We optimized the method of identification of lysine residues prone to glycation using the combination of LC-MS, isotopic labeling, and modified synthetic peptide standards with the glycated lysine derivative (Fmoc-Lys(i,i-Fru,Boc)-OH).
Neuroethology of male courtship in Drosophila: from the gene to behavior.
Review
Koganezawa et al., Sendai, Japan. In J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2014
Neurogenetic analyses in the fruit fly Drosophila melanogaster revealed that gendered behaviors, including courtship, are underpinned by sexually dimorphic neural circuitries, whose development is directed in a sex-specific manner by transcription factor genes, fruitless (fru) and doublesex (dsx), two core members composing the sex-determination cascade.
Genetic and neural mechanisms that inhibit Drosophila from mating with other species.
Impact
Shah et al., Beijing, China. In Cell, 2013
Male-specific Fruitless (Fru(M)), a master regulator of courtship, also inhibits interspecies courtship.
Fruitless recruits two antagonistic chromatin factors to establish single-neuron sexual dimorphism.
Impact
GeneRIF
Yamamoto et al., Sendai, Japan. In Cell, 2012
Study shows that Fru forms a complex with the transcriptional cofactor Bonus (Bon), which, in turn, recruits either of two chromatin regulators, Histone deacetylase 1 (HDAC1), which masculinizes individual sexually dimorphic neurons, or Heterochromatin protein 1a (HP1a), which demasculinizes them.
An olfactory receptor for food-derived odours promotes male courtship in Drosophila.
Impact
Benton et al., Lausanne, Switzerland. In Nature, 2011
Male Drosophila melanogaster fruitflies display stereotyped reproductive behaviours towards females, and these behaviours are controlled by the neural circuitry expressing male-specific isoforms of the transcription factor Fruitless (FRU(M)).
Proteasome-mediated turnover of the transcriptional activator FIT is required for plant iron-deficiency responses.
GeneRIF
Vert et al., Montpellier, France. In Plant J, 2011
FIT is post-translationally regulated by iron deficiency, leading to a decrease in FIT protein stability mediated by proteasome-dependent degradation.
Female contact activates male-specific interneurons that trigger stereotypic courtship behavior in Drosophila.
GeneRIF
Yamamoto et al., Sendai, Japan. In Neuron, 2011
Male courtship is initiated by direct activation of fru-expressing neurons in the absence of a courtship target.
The roles of fruitless and doublesex in the control of male courtship.
GeneRIF
Dauwalder, Houston, United States. In Int Rev Neurobiol, 2010
This chapter reviews the role of fruitless and the neurons that express it in the regulation of courtship behavior.
The hector G-protein coupled receptor is required in a subset of fruitless neurons for male courtship behavior.
GeneRIF
Dauwalder et al., Houston, United States. In Plos One, 2010
Signaling through the CG4395 G-protein coupled receptor in this subset of fru neurons is critical for male courtship behavior.
The Drosophila pheromone cVA activates a sexually dimorphic neural circuit.
Impact
Axel et al., New York City, United States. In Nature, 2008
In Drosophila, courtship involves a complex yet stereotyped array of dimorphic behaviours that are regulated by Fru(M), a male-specific isoform of the fruitless gene.
The neural and genetic substrates of sexual behavior in Drosophila.
Review
Yamamoto, Sendai, Japan. In Adv Genet, 2006
fruitless (fru), originally identified with its mutant conferring male homosexuality, is a neural sex determination gene in Drosophila that produces sexually dimorphic sets of transcripts.
Extra domains in secondary transport carriers and channel proteins.
Review
Saier et al., San Diego, United States. In Biochim Biophys Acta, 2006
Domains in secondary carriers include TrkA and SPX domains in DASS family members, DedA domains in TRAP-T family members (both of the IT superfamily), Kazal-2 and PDZ domains in OAT family members (of the MF superfamily), USP, IIA(Fru) and TrkA domains in ABT family members (of the APC superfamily), ricin domains in OST family members, and TrkA domains in AAE family members.
Blueprints for behavior: genetic specification of neural circuitry for innate behaviors.
Review
Baker et al., Stanford, United States. In Trends Neurosci, 2006
As we will discuss in this review, recent work has demonstrated that male-specific expression of Fruitless transcription factors (Fru(M) proteins) is necessary and sufficient to confer the potential for male courtship behaviors.
Fruitless specifies sexually dimorphic neural circuitry in the Drosophila brain.
Impact
GeneRIF
Yamamoto et al., Iwamizawa, Japan. In Nature, 2005
Fru expression can produce a male-specific neural circuit, probably used during heterosexual courtship, by preventing cell death in identifiable neurons
Fructose-2,6-bisphosphate: a traffic signal in plant metabolism.
Review
Villadsen et al., Frederiksberg, Denmark. In Trends Plant Sci, 2004
Fructose-2,6-bisphosphate (Fru-2,6-P(2)) regulates key reactions of the primary carbohydrate metabolism in all eukaryotes.
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