gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fibroblast growth factor receptor substrate 2

FRS2, FRS2alpha, fibroblast growth factor receptor substrate 2
Top mentioned proteins: FGFR1, ERK, MAPK, Grb2, Akt
Papers using FRS2 antibodies
Reggie-1 and reggie-2 localize in non-caveolar rafts in epithelial cells: cellular localization is not dependent on the expression of caveolin proteins.
Supplier
Ulrich Henning, In PLoS ONE, 2006
... GST-fusion constructs of FRS2 were constructed by subcloning into vector pGEX-4T-1 (GE Healthcare), and FRS2-His was obtained by subcloning into pSCherry2 (Eurogentec, Seraing, Belgium) ...
The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation
Supplier
Fernig David G et al., In Cell Communication and Signaling : CCS, 1998
... Anti-FRS2 was from Santa Cruz Biotechnology (Heidelberg, Germany) ...
Papers on FRS2
MicroRNA-145 repairs infarcted myocardium by accelerating cardiomyocyte autophagy.
New
Minatoguchi et al., Gifu, Japan. In Am J Physiol Heart Circ Physiol, Jan 2016
We determined fibroblast growth factor receptor substrate 2 mRNA to be a target of miR-145, both in an in vivo model and in H9c2 cells.
Antitumor effects and molecular mechanisms of ponatinib on endometrial cancer cells harboring activating FGFR2 mutations.
New
Sim et al., Seoul, South Korea. In Cancer Biol Ther, Dec 2015
AP24534 also diminished the kinase activity of immunoprecipitated FGFR2 derived from MFE-296 and MFE-280 cells and reduced the phosphorylation of FGFR2 and FRS2 on MFE-296 and AN3CA cells.
Peptidomimetic suppresses proliferation and invasion of gastric cancer cells by fibroblast growth factor 2 signaling cascade blockage.
New
Li et al., Wenzhou, China. In Anticancer Drugs, Dec 2015
It also inhibited the phosphorylation of FRS2, ERK1/2, and AKT triggered by FGF2 in GC.
FGFR3 biology and skeletal disease.
New
Horton et al., Portland, United States. In Connect Tissue Res, Nov 2015
Triggered by ligand binding or in some cases mutation, FGFR3 activation involves dimerization of receptor monomers, phosphorylation of specific tyrosine residues in the receptor's kinase domain and in the tightly linked scaffold protein Fibroblast Receptor Factor Substrate 2 (FRS2).
Oncogenic Signaling Adaptor Proteins.
Review
New
Hahn et al., Boston, United States. In J Genet Genomics, Nov 2015
In this review, we focus on the discovery, structure and function, and therapeutic implication of three of these adaptor oncogenes, CRKL, GAB2, and FRS2.
Fgfr1 regulates development through the combinatorial use of signaling proteins.
New
Soriano et al., New York City, United States. In Genes Dev, Oct 2015
Many lines of evidence have implicated Erk1/2 signaling induced through Frs2 as the predominant effector pathway downstream from Fgf receptors (Fgfrs), but these receptors can also signal through other mechanisms.
Identification of Oncogenic and Drug-Sensitizing Mutations in the Extracellular Domain of FGFR2.
New
Jänne et al., Boston, United States. In Cancer Res, Sep 2015
Both FGFR2-mutant forms are predominantly located in the endoplasmic reticulum and Golgi but nevertheless can activate downstream signaling pathways through their interactions with fibroblast growth factor receptor substrate 2 (FRS2).
Complexity of FGFR signalling in metastatic urothelial cancer.
Arkenau et al., Barcelona, Spain. In J Hematol Oncol, 2014
Exploratory biomarker analysis showed FGFR3, FGFR1, FGF-ligand and fibroblast growth factor receptor substrate 2 (FRS2) expression in the patient's tumour, together with the presence of a germ-line mutation in the FGFR3 extracellular binding domain.
FRS2α-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.
GeneRIF
Wang et al., Houston, United States. In Circ Res, 2012
FRS2alpha-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.
Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2.
GeneRIF
Tikkanen et al., Gießen, Germany. In Plos One, 2011
a novel signaling network containing FRS2, CAP and flotillin-1
High-resolution genomic mapping reveals consistent amplification of the fibroblast growth factor receptor substrate 2 gene in well-differentiated and dedifferentiated liposarcoma.
GeneRIF
Oliveira et al., Rochester, United States. In Genes Chromosomes Cancer, 2011
Validated FRS2 amplification in both Well-differentiated liposarcoma and dedifferentiated liposarcoma.
Independent roles of Fgfr2 and Frs2alpha in ureteric epithelium.
GeneRIF
Bates et al., Pittsburgh, United States. In Development, 2011
although Fgfr2 and Frs2alpha have crucial roles in the ureteric lineage, they appear to act separately and additively.
FRS2α is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts.
GeneRIF
Wang et al., Houston, United States. In Int J Biol Sci, 2010
The FGF signaling axis activates mTOR via the FGF receptor substrate 2alpha (FRS2alpha)-mediated PI3K/Akt pathway, and suppresses autophagy activity in MEFs.
Docking proteins.
Review
Daly et al., Freiburg, Germany. In Febs J, 2010
The growth factor receptor bound 2-associated binder/Daughter of Sevenless, insulin receptor substrate, fibroblast growth factor receptor substrate 2 and downstream of tyrosine kinases protein families fall into this category.
The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment.
Review
Gotoh et al., Tokyo, Japan. In Expert Opin Ther Targets, 2009
BACKGROUND: There are two members--FRS2alpha and FRS2beta--in the fibroblast growth factor receptor substrate 2 (FRS2) family of docking/scaffolding adaptor proteins.
Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells.
Review
GeneRIF
Gotoh, Tokyo, Japan. In Curr Stem Cell Res Ther, 2009
role in development and growth of neural progenitor cells
Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins.
Review
Gotoh, Tokyo, Japan. In Cancer Sci, 2008
The FRS2 family of adaptor/scaffold proteins has two members, FRS2alpha and FRS2beta.
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.
Impact
Nishida et al., Kyoto, Japan. In Nat Cell Biol, 2002
Next, they bind to the adaptor protein Grb2 and inhibit the recruitment of the Grb2-Sos complex either to the fibroblast growth factor receptor (FGFR) docking adaptor protein FRS2 or to Shp2.
N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling.
Impact
Christofori et al., Vienna, Austria. In Nat Cell Biol, 2001
Here we show that N-CAM modulates neurite outgrowth and matrix adhesion of beta-cells from pancreatic tumours by assembling a fibroblast-growth-factor receptor-4 (FGFR-4) signalling complex, which consists of N-cadherin, FGFR-4, phospholipase C gamma (PLC-gamma), the adaptor protein FRS2, pp60(c-src), cortactin and growth-associated protein-43 (GAP-43).
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.
Impact
Schlessinger et al., New York City, United States. In Cell, 1997
Finally, we demonstrate that FRS2 is closely related and probably indentical to SNT, the long-sought target of FGF and NGF receptors.
share on facebooktweetadd +1mail to friends