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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Formin-like 1

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, Cripto, Epidermal Growth Factor, Actin, ACID
Papers on FRL
α2-adrenoceptor binding in Flinders-sensitive line compared with Flinders-resistant line and Sprague-Dawley rats.
Landau et al., Århus, Denmark. In Acta Neuropsychiatr, Dec 2015
METHODS: Using in vitro autoradiography techniques and the selective α2-ligand, [3H]RX 821002, we investigated the density of α2-adrenoceptors in female Flinders-sensitive line (FSL) rats, a validated model of depression, and in two traditional control groups - female Flinders-resistant line (FRL) and Sprague-Dawley (SD) rats.
Cripto-1 Ablation Disrupts Alveolar Development in the Mouse Mammary Gland through a Progesterone Receptor-Mediated Pathway.
Raafat et al., Bethesda, United States. In Am J Pathol, Nov 2015
Cripto-1, a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic family, is critical for early embryonic development.
Cripto-1 modulates macrophage cytokine secretion and phagocytic activity via NF-κB signaling.
Song et al., Changchun, China. In Immunol Res, Nov 2015
UNASSIGNED: Cripto-1 is an oncogenic protein belonging to the epidermal growth factor-Cripto-1/FRL-1/Cryptic family.
Development of co-dominant SCAR markers linked to resistant gene against the Fusarium oxysporum f. sp. radicis-lycopersici.
Ikten et al., Antalya, Turkey. In Theor Appl Genet, Sep 2015
We developed highly reliable co-dominant SCAR markers linked to the Frl gene.
The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation.
Geyer et al., Bonn, Germany. In Nat Commun, 2014
The crystal structures of the N-terminal domains of human FMNL1 and FMNL2 in complex with active Cdc42 show that Cdc42 mediates contacts with all five armadillo repeats of the formin with specific interactions formed by the Rho-GTPase insert helix.
Design and Synthesis of a Novel Cationic Peptide with Potent and Broad-Spectrum Antimicrobial Activity.
Kong et al., Zhengzhou, China. In Biomed Res Int, 2014
KW-13, a novel cationic α-helical antibacterial peptide consisting of 13 amino acid residues, was designed and chemically synthesized.
The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition.
Salomon et al., Frederick, United States. In Semin Cancer Biol, 2014
As a member of the epidermal growth factor (EGF)/Cripto-1-FRL-1-Cryptic (CFC) family, CR-1 functions as an obligatory co-receptor for the transforming growth factor-β (TGF-β) family members, Nodal and growth and differentiation factors 1 and 3 (GDF1/3) by activating Alk4/Alk7 signaling pathways that involve Smads 2, 3 and 4. In addition, CR-1 can activate non-Smad-dependent signaling elements such as PI3K, Akt and MAPK.
RhoA-mediated FMNL1 regulates GM130 for actin assembly and phosphorylates MAPK for spindle formation in mouse oocyte meiosis.
Sun et al., Nanjing, China. In Cell Cycle, 2014
Formin-like 1 (FMNL1) is a member of Formin family proteins which are the actin nucleators.
RfpA, RfpB, and RfpC are the Master Control Elements of Far-Red Light Photoacclimation (FaRLiP).
Bryant et al., United States. In Front Microbiol, 2014
Terrestrial cyanobacteria often occur in niches that are strongly enriched in far-red light (FRL; λ > 700 nm).
Formins as effector proteins of Rho GTPases.
Geyer et al., Bonn, Germany. In Small Gtpases, 2013
In this review we discuss the current knowledge on the structure, activation, and function of formin-GTPase interactions for the mammalian formin families Dia, Daam, FMNL, and FHOD.
Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.
Bianco et al., Frederick, United States. In Am J Pathol, 2012
Cripto-1, a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family, together with the transforming growth factor (TGF)-β family ligand Nodal, regulates both cell movement and EMT during embryonic development.
Selectively bred rodents as models of depression and anxiety.
Neumann et al., Århus, Denmark. In Curr Top Behav Neurosci, 2011
We will summarize major behavioral, neuroendocrine and neuronal parameters, and pharmacological interventions, assessed in great detail in two rat model systems: The Flinders Sensitive and Flinders Resistant Line rats (FSL/FRL model), and rats selectively bred for high (HAB) or low (LAB) anxiety related behavior (HAB/LAB model).
Bi-modal regulation of a formin by srGAP2.
Soderling et al., Durham, United States. In J Biol Chem, 2011
after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics.
The formin FRL1 (FMNL1) is an essential component of macrophage podosomes.
Blystone et al., Syracuse, United States. In Cytoskeleton (hoboken), 2010
Our data suggest that FRL1 is responsible for modifying actin at the macrophage podosome and may be involved in actin cytoskeleton dynamics during adhesion and migration within tissues.
Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing.
Krackhardt et al., München, Germany. In J Biol Chem, 2009
Results describe N-myristoylation as a regulative mechanism of FMNL1 responsible for membrane trafficking potentially involved in a diversity of polarized processes of hematopoietic lineage-derived cells.
Riding shotgun: a dual role for the epidermal growth factor-Cripto/FRL-1/Cryptic protein Cripto in Nodal trafficking.
Constam, Lausanne, Switzerland. In Traffic, 2009
Nodal is a secreted protein of the transforming growth factor beta (TGFbeta) family that activates Smad2 and Smad3 transcription factors through complexes of type I and type II activin receptors and glycosyl-phosphatidylinositol-anchored coreceptors of the epidermal growth factor-like Cripto/FRL-1/Cryptic family.
The filamentous actin cross-linking/bundling activity of mammalian formins.
Wirtz et al., Baltimore, United States. In J Mol Biol, 2009
In vitro rheologic assays were used to deconvolve the dynamic cross-linking activity from the bundling activity of formin FRL1 and the closely related mDia1 and mDia2.
Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse.
Billadeau et al., Rochester, United States. In Immunity, 2007
Conversely, the actin-nucleating formins, Diaphanous-1 (DIA1) and Formin-like-1 (FMNL1), did not affect TCR-stimulated F-actin-rich structures, but instead displayed unique patterns of centrosome colocalization and controlled TCR-mediated centrosome polarization.
Analysis of a new allele of limb deformity (ld) reveals tissue- and age-specific transcriptional effects of the Ld Global Control Region.
Kirschner et al., Columbus, United States. In Int J Dev Biol, 2006
A new allele of limb deformity is described due to complete deletion of Fmn1, including its global control region.
Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation.
Schier et al., New York City, United States. In Cell, 1998
The oep gene encodes a novel EGF-related protein with similarity to the EGF-CFC proteins cripto, cryptic, and FRL-1.
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