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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Frizzled family receptor 1

Frizzled, Frizzled-1, FZD1
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, PKI, Wnt5a, Wnt3a
Papers using Frizzled antibodies
Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression.
Supplier
Tjwa Marc, In PLoS ONE, 1999
... The Frizzled 10-CreER™ transgenic mouse line was generated ...
Papers on Frizzled
Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.
New
Henry et al., Urbana, United States. In Exp Eye Res, Feb 2016
Numerous frizzled receptors (fzd1, fzd2, fzd3, fzd4, fzd6, fzd7, fzd8, and fzd10) and wnt ligands (wnt2b.a,
Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling.
New
Wang et al., Xiamen, China. In Biosci Rep, Feb 2016
We here showed that SNX27 interacts with Frizzled (Fzd) receptors via PDZ domain interaction.
Uterine leiomyosarcoma and endometrial stromal sarcoma have unique miRNA signatures.
New
Davidson et al., Jerusalem, Israel. In Gynecol Oncol, Feb 2016
Frizzled-6 protein expression was analyzed in 30 LMS (15 primary, 15 metastases).
Secreted Frizzled-Related Protein 2 (sFRP2) Functions as a Melanogenic Stimulator; the Role of sFRP2 in UV-Induced Hyperpigmentary Disorders.
New
Kang et al., Suwŏn, South Korea. In J Invest Dermatol, Jan 2016
In this study, we found that secreted frizzled-related protein 2 (sFRP2) is overexpressed in the hyperpigmentary skin of melasma and solar lentigo and in acutely UV-irradiated skin.
Fibrosis in the lens. Sprouty regulation of TGFβ-signaling prevents lens EMT leading to cataract.
Review
New
McAvoy et al., Sydney, Australia. In Exp Eye Res, Jan 2016
However, recent research provides key insights into an FGF-activated mechanism intrinsic to the lens that involves interactions between the Wnt-Frizzled and Jagged/Notch signaling pathways.
Thymosin Beta-4 Suppresses Osteoclastic Differentiation and Inflammatory Responses in Human Periodontal Ligament Cells.
New
Kim et al., Ch'ŏnan, South Korea. In Plos One, Dec 2015
In addition, H2O2 up-regulated Wnt5a and its cell surface receptors, Frizzled and Ror2 in PDLCs.
Frizzleds and WNT/β-catenin signaling--The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics.
Review
New
Schulte, Sweden. In Eur J Pharmacol, Oct 2015
The lipoglycoproteins of the mammalian WNT family induce β-catenin-dependent signaling through interaction with members of the Class Frizzled receptors and LDL receptor-related protein 5/6 (LRP5/6) albeit with unknown selectivity.
A Molecular Pharmacologist's Guide to G Protein-Coupled Receptor Crystallography.
Review
New
Deupi et al., Switzerland. In Mol Pharmacol, Sep 2015
There are now over 120 GPCR crystal structures deposited in the Protein Data Bank of 32 different receptors from families scattered across the phylogenetic tree, including class B, C, and Frizzled GPCRs.
Targeting Wnts at the source--new mechanisms, new biomarkers, new drugs.
Review
New
Virshup et al., Singapore, Singapore. In Mol Cancer Ther, May 2015
Such agents include inhibitors of Wnt secretion, as well as recombinant proteins that minimize Wnt-Frizzled interactions.
Wnt acylation and its functional implication in Wnt signalling regulation.
Review
New
Garcia et al., Stanford, United States. In Biochem Soc Trans, Apr 2015
Intriguingly, the crystal structure of XWnt8 in complex with the extracellular domain of the Frizzled 8 cysteine-rich domain (Fzd8-CRD) revealed that Wnts use the fatty acid as a 'hotspot' residue to engage its receptor, which is a unique mode of receptor-ligand recognition.
Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila.
Impact
Mlodzik et al., New York City, United States. In Nat Cell Biol, 2013
PCP is established through interactions of the core Frizzled (Fz)/PCP factors and, although their molecular interactions are beginning to be understood, the upstream input providing the directional bias and polarity axis remains unknown.
Fibronectin regulates Wnt7a signaling and satellite cell expansion.
Impact
Rudnicki et al., Ottawa, Canada. In Cell Stem Cell, 2013
We found that Syndecan-4 (Sdc4) and Frizzled-7 (Fzd7) form a coreceptor complex in satellite cells and that binding of the ECM glycoprotein Fibronectin (FN) to Sdc4 stimulates the ability of Wnt7a to induce the symmetric expansion of satellite stem cells.
Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity.
Impact
Nathans et al., Baltimore, United States. In Cell, 2013
In the adult retina and cerebellum, gain or loss of Norrin/Fz4 signaling results in a cell-autonomous gain or loss, respectively, of blood retina barrier and blood brain barrier function, indicating an ongoing requirement for Frizzled signaling in barrier maintenance and substantial plasticity in mature CNS vascular structure.
Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/β-catenin pathway.
GeneRIF
Zhou et al., Jinan, China. In Cancer Lett, 2012
FZD1 appears to mediate multidrug resistance by regulating the Wnt/beta-catenin pathway
Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity.
GeneRIF
Lawrence et al., New York City, United States. In Development, 2012
Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity.
Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche.
Impact
Li et al., Kansas City, United States. In Cell, 2012
Here, we show Flamingo (Fmi) and Frizzled (Fz) 8, members of noncanonical Wnt signaling, both express in and functionally maintain quiescent long-term HSCs.
Localized netrins act as positional cues to control layer-specific targeting of photoreceptor axons in Drosophila.
GeneRIF
Salecker et al., London, United Kingdom. In Neuron, 2012
Frazzled is expressed and cell autonomously required in R8 photoreceptors for directing their axons to the medulla-neuropil layer M3.
Planar cell polarity controls directional Notch signaling in the Drosophila leg.
GeneRIF
Galindo et al., Valencia, Spain. In Development, 2012
Frizzled and Dishevelled are enriched at distal sides of each cell and hence localize at the interface with ligand-expressing cells in the non-responding cells.
Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes.
Impact
Komuro et al., Ōsaka, Japan. In Cell, 2012
C1q activates canonical Wnt signaling by binding to Frizzled receptors and subsequently inducing C1s-dependent cleavage of the ectodomain of Wnt coreceptor low-density lipoprotein receptor-related protein 6.
Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8.
GeneRIF
Musso et al., Rennes, France. In Plos One, 2011
Soluble FZC18 and Wnt3a physically interact in a cell-free system and soluble FZC18 binds the frizzled 1 and 8 receptors.
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