GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Aug 2016.
FERM, RhoGEF and pleckstrin domain protein 2
This gene encodes a member of the folate receptor (FOLR) family, members of which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene includes two polymorphic variants; the shorter one has two base deletion in the CDS, resulting in a truncated polypeptide, compared to the longer one. Both protein products are constitutively secreted in hematopoietic tissues and are potential serum marker for certain hematopoietic malignancies. The longer protein has a 71% and 79% sequence homology with the FOLR1 and FOLR2 proteins, respectively. [provided by RefSeq, Jul 2008] (from
Zissel Gernot et al., In Respiratory Research, 2003
... pyruvate from Biochrom (Berlin, FRG); trypsin/EDTA solution from Boehringer-Mannheim (Mannheim, FRG); collagen R from Serva (Heidelberg, FRG); chloroform and isopropanol from Merck (Darmstadt, FRG); recombinant human ...
METHODS: HIV-1 and HBV markers determinations (Roche, FRG; Abbott, USA) and HBV genome-length retrospective analysis were performed in follow-up isolates from patients who were either stably HBsAg-negative with a low level of HBV DNA (occult hepatitis B infection, OBI) or HBsAg-positive with a high level of HBV DNA.
Rueff et al., Lisbon, Portugal. In Kidney Int Suppl, 2011
Mutations in SLC5A2, the SGLT2 coding gene, are responsible for familial renal glucosuria (FRG), a genetic disorder characterized by glucosuria in the absence of both hyperglycemia and generalized proximal tubular dysfunction.
Malformations observed at birth or immediately afterwards happen according to the definition with a frequency of 2 to 4% (FRG), according to sources from other countries with a frequency of 2.5 to 6.5%.