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Frequently rearranged in advanced T-cell lymphomas 2

FRAT2, frequently rearranged in advanced T-cell lymphomas-2, hFRAT2
The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FRAT1, ACID, Frizzled, FZD5, FZD3
Papers on FRAT2
The microRNA-29 family in cartilage homeostasis and osteoarthritis.
Clark et al., Farmington, United States. In J Mol Med (berl), Jan 2016
Amongst these, FZD3, FZD5, DVL3, FRAT2, and CK2A2 were validated as direct targets of the miR-29 family.
Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype.
Sun et al., Guiyang, China. In Oncotarget, Mar 2015
MiR-29c directly suppressed the following Wnt upstream regulators: frequently rearranged in advanced T-cell lymphomas 2 (FRAT2), low-density lipoprotein receptor-related protein 6 (LRP6), Frizzled-4 (FZD4) and Frizzled-5 (FZD5).
Frat2 mediates the oncogenic activation of Rac by MLL fusions.
Williams et al., London, United Kingdom. In Blood, 2013
Here, we demonstrate that MLL fusion oncogenes maintain leukemia-associated Rac activity by regulating Frat gene expression, specifically Frat2.
The database of chromosome imbalance regions and genes resided in lung cancer from Asian and Caucasian identified by array-comparative genomic hybridization.
Wang et al., Tainan City, Taiwan. In Bmc Cancer, 2011
functioning in Rho activity control, FRAT2 (10q24.1)
Hypoxic culture maintains self-renewal and enhances embryoid body formation of human embryonic stem cells.
Ho et al., Taipei, Taiwan. In Tissue Eng Part A, 2010
Most tested genes belonging to FGF, TGF-beta/GMP, and Wnt signaling pathways were enriched in undifferentiated hES cells and downregulated upon differentiation, accompanied with differential expression of FGFR1, FGFR2, and FRAT2 between hypoxia and normoxia.
Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways.
Berns et al., Amsterdam, Netherlands. In Oncogene, 2010
Data show that that Frat synergizes with Diversin in the activation of JNK/AP-1 signaling.
Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting.
Freemantle et al., United States. In Bmc Cancer, 2008
Wnt pathway gene expression levels were compared during induced differentiation and many components were altered including ligands (WNT2B), receptors (FZD5, FZD6, FZD10), secreted inhibitors (SFRP4, SFRP1), and other effectors of Wnt signalling (FRAT2, DAAM1, PITX2, Porcupine).
Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms.
Wang et al., Wuhan, China. In Neurobiol Aging, 2008
It suggests that activation of GSK-3 inhibits PP-2A through up-regulation of I(2)(PP-2A) with hnRNP A18-involved mechanism.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
Identification and characterization of rat Dact1 and Dact2 genes in silico.
Katoh et al., Japan. In Int J Mol Med, 2005
DACT1 (DAPPER1), Frizzled receptors, MUSK receptor, VANGL1, VANGL2, PRICKLE1, PRICKLE2, DAAM1, Casein kinases, MARK3 (PAR1), PP2C, AXIN1, AXIN2, NKD1, NKD2, FRAT1, FRAT2 and CXXC4 are WNT signaling molecules associating with Dishevelled family proteins.
Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays.
Sasaki et al., Tokyo, Japan. In Cancer Res, 2005
By using microarrays, we identified 1,383 gene candidates reactivated in at least one cell line of eight gastric cancer cell lines after treatment with 5-aza-2'deoxycytidine and trichostatin A. Of the 1,383 genes, 159 genes, including oncogenes ELK1, FRAT2, R-RAS, RHOB, and RHO6, were further selected as gene candidates that are silenced by DNA methylation in normal stomach mucosa but are activated by DNA demethylation in a subset of gastric cancers.
FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation.
Johnson et al., Birmingham, United States. In J Biol Chem, 2005
FRAT-2 enhances glycogen synthase kinase 3 beta-mediated phosphorylation of a primed substrate to a greater extent than an unprimed substrate
Denervation-induced alterations in gene expression in mouse skeletal muscle.
T├ągerud et al., Kalmar, Sweden. In Eur J Neurosci, 2005
A set of five genes with altered expression after denervation (Fzd9, Nr4a1, Frat2, Ctgf and Cyr61) indicate that Wnt signalling may be reduced in denervated skeletal muscle.
Characterization and functional analysis of the murine Frat2 gene.
Berns et al., Amsterdam, Netherlands. In J Biol Chem, 2004
Here we describe the cloning and characterization of a third murine Frat homologue, Frat2, which is the mouse ortholog of human FRAT2.
Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer.
Katoh et al., Tokyo, Japan. In Int J Oncol, 2002
We have so far cloned and characterized human WNT signaling molecules WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT10A, WNT10B, WNT11, WNT14, WNT14B/WNT15, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1/STB2, ARHU/WRCH1, ARHV/WRCH2, GIPC2, GIPC3, betaTRCP2/FBXW1B, SOX17, and TCF-3 using bioinformatics, cDNA-library screening, and cDNA-PCR.
WNT3-WNT14B and WNT3A-WNT14 gene clusters (Review).
Katoh, Tokyo, Japan. In Int J Mol Med, 2002
FRAT1, FRAT2, and PAR-1 are positive regulators of WNT - beta-catenin pathway.
Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2.
Dmitrovsky et al., United States. In Gene, 2002
We have isolated the entire coding sequence of human FRAT2 (frequently rearranged in advanced T-cell lymphomas-2).
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