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Frequently rearranged in advanced T-cell lymphomas

FRAT1, proto-oncogene Frat1
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: CAN, Axin, FRAT2, ACID, TCF
Papers on FRAT1
The clinical significance of FRAT1 and ABCG2 expression in pancreatic ductal adenocarcinoma.
Zou et al., Changsha, China. In Tumour Biol, Dec 2015
This study investigated the clinicopathological significances of frequently rearranged in advanced T-cell lymphomas-1 (FRAT1) and ATP-binding cassette subfamily G member 2 (ABCG2) expression in PDAC.
Comparative two-dimensional polyacrylamide gel electrophoresis of the salivary proteome of children with autism spectrum disorder.
Darie et al., United States. In J Cell Mol Med, Nov 2015
Increased expression of proto-oncogene Frequently rearranged in advanced T-cell lymphomas 1 (FRAT1), Kinesin family member 14, Integrin alpha6 subunit, growth hormone regulated TBC protein 1, parotid secretory protein, Prolactin-inducible protein precursor, Mucin-16, Ca binding protein migration inhibitory factor-related protein 14 (MRP14) was observed in individuals with ASD.
The clinical pathological significance of FRAT1 and ROR2 expression in cartilage tumors.
Wang et al., Changsha, China. In Clin Transl Oncol, Jun 2015
This study investigated the protein expression and clinicopathological significance of ROR2 and FRAT1 in 59 chondrosarcomas and 33 osteochondromas.
[Effect of irradiated human lung fibroblasts on activation of canonical Wnt/β-catenin signaling pathway in mesenchymal stem cells].
Chen et al., Beijing, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, Mar 2015
The protein levels of GSK-3β, p-GSK-3β, FRAT1 and β-catenin in HUMSCs were examined by Western blotting 3 days after culture or co-culture.
Overexpression of FRAT1 is associated with malignant phenotype and poor prognosis in human gliomas.
Zhao et al., Beijing, China. In Dis Markers, 2014
FRAT1 is a positive regulator of the Wnt/β-catenin signaling pathway and is overexpressed in many human tumors.
Therapeutic Potential of Umbilical Cord Mesenchymal Stem Cells for Inhibiting Myofibroblastic Differentiation of Irradiated Human Lung Fibroblasts.
Feng et al., In Tohoku J Exp Med, 2014
We also measured the expression of FRAT1 that can enhance the Wnt/β-catenin signaling by stabilizing β-catenin.
The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of β-catenin through mechanisms involving FRAT1 and PAK4.
Richardson et al., Sydney, Australia. In J Cell Sci, 2014
The mechanism of inhibiting β-catenin phosphorylation involves the NDRG1-mediated upregulation of the GSK3β-binding protein FRAT1, which prevents the association of GSK3β with the Axin1-APC-CK1 destruction complex and the subsequent phosphorylation of β-catenin.
Mutations in MAP3K1 tilt the balance from SOX9/FGF9 to WNT/β-catenin signaling.
Ostrer et al., In Hum Mol Genet, 2014
In transformed B-lymphoblastoid cell lines and NT2/D1 cells transfected with wild-type or mutant MAP3K1 cDNAs under control of the constitutive CMV promoter, these mutations increased binding of RHOA, MAP3K4, FRAT1 and AXIN1 and increased phosphorylation of p38 and ERK1/2.
WNT1 gene expression alters in heterogeneous population of prostate cancer cells; decreased expression pattern observed in CD133+/CD44+ prostate cancer stem cell spheroids.
Oktem et al., Manisa, Turkey. In J Buon, 2014
The expression levels of WNT1, FZD1, ADAR, APC, AXIN, BTRC, FRAT1 and PPARD genes were measured by polymerase chain reaction (PCR) array assay and the protein expression levels of WNT1, FZD and AXIN by immunohistochemistry. RESULTS: The expression levels of WNT pathway-related molecules were found to increase in both CSCs and non- CSCs when CSCs were maintained as spheroids.
Knockdown of FRAT1 expression by RNA interference inhibits human glioblastoma cell growth, migration and invasion.
Guo et al., Taiyuan, China. In Plos One, 2012
BACKGROUND: FRAT1 positively regulates the Wnt/β-catenin signaling pathway by inhibiting GSK-3-mediated phosphorylation of β-catenin.
Expression of Frat1 correlates with expression of β-catenin and is associated with a poor clinical outcome in human SCC and AC.
Wang et al., Shenyang, China. In Tumour Biol, 2012
Overexpression of frequently rearranged in advanced T-cell lymphomas 1 (Frat1) has been reported in several human malignant tumors, but the relationship between Frat1 and β-catenin in lung cancer is still unclear.
Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells.
Dalton et al., Athens, United States. In Mol Cell Biol, 2012
Gsk3b is exported from the nucleus in a complex with Frat. Loss of PI3K/Akt activity results in dissociation of this complex and retention of Gsk3b in the nucleus.
Overexpression of Frat1 correlates with malignant phenotype and advanced stage in human non-small cell lung cancer.
Wang et al., Shenyang, China. In Virchows Arch, 2011
Down-regulation of Frat1 expression reduced invasive ability in A549 cell line, further supporting idea that Frat1 may play crucial role in carcinogenesis, tumor invasiveness and dissemination in human lung cancer.
Neuronal pentraxin 1 induction in hypoxic-ischemic neuronal death is regulated via a glycogen synthase kinase-3α/β dependent mechanism.
Hossain et al., Baltimore, United States. In Cell Signal, 2011
Similarly, overexpression of the GSK-3β inhibitor Frat1 or the kinase mutant GSK-3βKM, but not the wild-type GSK-3βWT, blocked NP1 induction and rescued neurons from death.
FRAT1 expression and its correlation with pathologic grade, proliferation, and apoptosis in human astrocytomas.
Chen et al., Xi'an, China. In Med Oncol, 2011
Elevated expression of FRAT1 was associated with astrocytomas.
The expression profile of FRAT1 in human gliomas.
Zhuo et al., Xi'an, China. In Brain Res, 2010
Our results suggest that FRAT1 may be an important factor in the tumorigenesis and progression of gliomas, and could be used as a potential molecular marker for pathological diagnosis and a target for biological therapy.
Frat oncoproteins act at the crossroad of canonical and noncanonical Wnt-signaling pathways.
Berns et al., Amsterdam, Netherlands. In Oncogene, 2010
Data show that that Frat synergizes with Diversin in the activation of JNK/AP-1 signaling.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
From 1996 to 2002, we cloned and characterized WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT9A/WNT14, WNT9B/WNT14B, WNT10A, WNT10B, WNT11, FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD10, FRAT1, FRAT2, NKD1, NKD2, VANGL1, RHOU/ARHU, RHOV/ARHV, GIPC2, GIPC3, FBXW11/betaTRCP2, SOX17, TCF7L1/TCF3, and established a cDNA-PCR system for snap-shot and dynamic analyses on the WNT-transcriptome.
WNT3-WNT14B and WNT3A-WNT14 gene clusters (Review).
Katoh, Tokyo, Japan. In Int J Mol Med, 2002
FRAT1, FRAT2, and PAR-1 are positive regulators of WNT - beta-catenin pathway.
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