Histopathologic and immunophenotypical criteria for the diagnosis of Sézary syndrome in differentiation from other erythrodermic skin diseases: An EORTC Cutaneous Lymphoma Task Force Study of 97 cases.
Mannheim, Germany. In Br J Dermatol, 09 May 2015
Evaluation criteria were: epidermal and dermal changes, morphology of the infiltrate, immunohistochemical analysis of marker loss (CD2, CD3, CD4, CD5 and CD7), bystander infiltrate by stainings for CD8, FOXP3 and CD25 and expression of Ki-67, CD30, PD-1 and MUM-1.
Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without Carboplatin in human epidermal growth factor receptor 2-positive and triple-negative primary breast cancers.
Rostock, Germany. In J Clin Oncol, 20 Apr 2015
mRNA expression of immune-activating (CXCL9, CCL5, CD8A, CD80, CXCL13, IGKC, CD21) as well as immunosuppressive factors (IDO1, PD-1, PD-L1, CTLA4, FOXP3) was measured in 481 tumors.
Graft versus host disease: New insights into A2A receptor agonist therapy.
Bethesda, United States. In Comput Struct Biotechnol J, Dec 2014
These agonists have been shown in vitro to increase the TGFβ-induced generation of FoxP3(+) regulatory T cells (Tregs) and in vivo to improve weight gain and mortality as well as inhibit the release of pro-inflammatory cytokines in GVHD murine models [2,3].
Vitamin D Actions on CD4(+) T Cells in Autoimmune Disease.
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Madison, United States. In Front Immunol, Dec 2014
Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3(+)CD4(+) T-regulatory cell and CD4(+) T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch.
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
In PLoS ONE, 2004
... anti-CD86 (BU63, Serotec), anti-CD123 (9F5, BD Biosciences), anti-CD127 (HIL-7R-M21, BD Pharmingen), anti-CD303 (AC144, Miltenyi Biotec), anti-Foxp3 (259D, eBioscience), anti-CTLA-4 (BNI3, BD Biosciences) ...