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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Forkhead box P3

Foxp3
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CD25, CAN, IL-10, HAD
Papers using Foxp3 antibodies
The Living Eye “Disarms” Uncommitted Autoreactive T Cells by Converting Them to Foxp3+ Regulatory Cells following Local Antigen Recognition
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Gregerson Dale S. et al., In Frontiers in Immunology, 2011
... Foxp3-GFP and Foxp3-DTR/GFP transgenic mice on the B6 ...
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
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Unutmaz Derya, In PLoS ONE, 2010
... FoxP3-FITC (eBioscience, San Diego, USA), ICOS-PE ...
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
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Baumgrass Ria et al., In Frontiers in Immunology, 2006
... fixed and permeabilized using the FOXP3 staining buffer set (eBioscience) and stained with antibodies against FOXP3-FITC (eBioscience), IL-2-APC (BD), IL-4-PE (BD), ...
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
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Han Xiaonan et al., In EMBO Molecular Medicine, 2006
... CD4, CD25 and Foxp3 were from eBioscience (San Diego, CA) ...
BAC to immunology – bacterial artificial chromosome-mediated transgenesis for targeting of immune cells
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Freitas Antonio A., In PLoS ONE, 2006
... ; The Jackson Laboratory) and Foxp3 BAC transgenic mice expressing a human diphtheria ...
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Papers on Foxp3
A Treg gene signature is a specific and sensitive biomarker to identify children with new onset type 1 diabetes.
New
Levings et al., Vancouver, Canada. In Diabetes, 19 Feb 2016
Using biomarker discovery analysis, we found that expression of a combination of 6-genes, including TNFRSF1B (CD120b) and FOXP3, was significantly different between Tregs from subjects with new onset T1D and controls, resulting in a sensitive (0.86±0.14) and specific (0.78±0.18) biomarker algorithm.
Ultraviolet Irradiation Promotes FOXP3 Transcription via p53 in Psoriasis.
New
Shen et al., Chongqing, China. In Exp Dermatol, 19 Feb 2016
UNASSIGNED: The decrease of forkhead box P3-positive (FOXP3+) regulatory T cells (Tregs) causes an immune imbalance with effector T cells in psoriasis.
CD4(+) regulatory T cells in gastric cancer mucosa are proliferating and express high levels of IL-10 but little TGF-β.
New
Lundin et al., Göteborg, Sweden. In Gastric Cancer, 18 Feb 2016
BACKGROUND: An increase of regulatory T cells, defined as CD25(high)- and/or FOXP3(+)-expressing CD4(+) T cells, within tumors has been reported in several studies.
Sirt1 positive lymphocytes in acute cellular cardiac allograft rejection: contributor to pathogenesis and a therapeutic target.
New
Brown et al., Houston, United States. In Asaio J, 13 Feb 2016
Twelve of the 13 cases (92.3%) had an elevated CD8/FoxP3 ratio, coinciding with acute cellular rejection.
MicroRNAs in CD4(+) T cell subsets are markers of disease risk and T cell dysfunction in individuals at risk for type 1 diabetes.
New
Harrison et al., Australia. In J Autoimmun, 10 Feb 2016
UNASSIGNED: MicroRNAs (miRNAs) regulate T cell development and function and the disruption of miRNAs in natural regulatory CD4(+) FOXP3(+) T cells (nTreg) leads to autoimmune disease in mice.
Cellular functions of programmed cell death 5.
New
Chen et al., Beijing, China. In Biochim Biophys Acta, 08 Feb 2016
Recent evidence suggests that PDCD5 participates in immune regulation by promoting regulatory T cell function via the PDCD5-TIP60-FOXP3 pathway.
Immune homeostasis enforced by co-localized effector and regulatory T cells.
New
Impact
Germain et al., Bethesda, United States. In Nature, 10 Jan 2016
FOXP3(+) regulatory T cells (Treg cells) prevent autoimmunity by limiting the effector activity of T cells that have escaped thymic negative selection or peripheral inactivation.
Regulatory T Cell Immunotherapy in Immune-Mediated Diseases.
New
Negrin et al., Stanford, United States. In Curr Stem Cell Rep, 01 Jan 2016
In this review we will focus on forkhead box P3 (FoxP3) positive regulatory T cells, T regulatory type 1 cells and invariant natural killer T cells (iNKT).
The Comparison of the Immunologic Properties of Stem Cells Isolated from Human Exfoliated Deciduous Teeth, Dental Pulp, and Dental Follicles.
New
Akkoc et al., İstanbul, Turkey. In Stem Cells Int, 31 Dec 2015
Then, lymphocyte proliferation, the number of CD4(+)FoxP3(+) T regulatory cells, and the levels of Fas/Fas ligand, IL-4, IL-10, and IFN-γ in the culture supernatant were measured.
Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants.
New
Impact
Matarese et al., Napoli, Italy. In Nat Immunol, Nov 2015
Human regulatory T cells (T(reg) cells) that develop from conventional T cells (T(conv) cells) following suboptimal stimulation via the T cell antigen receptor (TCR) (induced T(reg) cells (iT(reg) cells)) express the transcription factor Foxp3, are suppressive, and display an active proliferative and metabolic state.
Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.
New
Impact
Cantor et al., Boston, United States. In Science, Nov 2015
We report that impaired expression of the transcription factor (TF) Helios by FoxP3(+) CD4 and Qa-1-restricted CD8 T(regs) results in defective regulatory activity and autoimmunity in mice.
MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells.
New
Impact
Benoist et al., Boston, United States. In Science, Sep 2015
T regulatory cells that express the transcription factor Foxp3 (Foxp3(+) T(regs)) promote tissue homeostasis in several settings.
AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.
New
Impact
Jordan et al., Bethesda, United States. In Science, Aug 2015
We found that LRBA colocalized with CTLA4 in endosomal vesicles and that LRBA deficiency or knockdown increased CTLA4 turnover, which resulted in reduced levels of CTLA4 protein in FoxP3(+) regulatory and activated conventional T cells.
Decreased Circulating T Regulatory Cells in Egyptian Patients with Nonsegmental Vitiligo: Correlation with Disease Activity.
Attia et al., Ţanţā, Egypt. In Dermatol Res Pract, 2014
Regulatory T cells (Tregs), specifically CD4(+)CD25(+) and Forkhead box P3(+) (FoxP3(+)) Tregs, acquired notable attention because of their role in a variety of autoimmune pathologies.
Influence of sirolimus-induced TGF-β secretion on mouse Treg cell proliferation.
Zhu et al., Guangzhou, China. In Genet Mol Res, 2014
We examined the effects of co-culturing CD4+ CD25+ Treg cells with sirolimus or cyclosporin A on Treg cell proliferation and differentiation and on transforming growth factor-β (TGF-β) and Foxp3 expression.
Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut.
GeneRIF
von Boehmer et al., Boston, United States. In J Exp Med, 2012
binding of Smad3 to the foxp3 enhancer is dispensable for regulatory T cell development in newborn and adult mice with the exception of the gut
Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions.
GeneRIF
Gorochov et al., Paris, France. In Ann Rheum Dis, 2012
Active and diffuse forms of sclerosis are associated with a FoxP3 signature.
Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms.
GeneRIF
Hancock et al., Philadelphia, United States. In Sci Signal, 2012
Data indicate that although histone deacetylases HDAC6, HDAC9, and Sirt1 all deacetylated Foxp3, each protein had different effects on transcription factors that control expression of the gene encoding Foxp3.
Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
GeneRIF
Aurora et al., Saint Louis, United States. In Plos One, 2011
Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
FoxP3⁺ regulatory CD4 T cells control the generation of functional CD8 memory.
GeneRIF
Taoufik et al., Le Kremlin-Bicêtre, France. In Nat Commun, 2011
FoxP3 positive regulatory CD4 T cells control the generation of functional CD8 memory.
More papers using Foxp3 antibodies
FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.
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Kretschmer Karsten et al., In Frontiers in Immunology, 2006
... ) mice on the C57BL/6 background, as well as Foxp3 bacterial artificial chromosome (BAC) transgenic mice expressing a Cre recombinase-GFP ...
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
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Zheng Song Guo, In PLoS ONE, 2004
... anti-CD86 (BU63, Serotec), anti-CD123 (9F5, BD Biosciences), anti-CD127 (HIL-7R-M21, BD Pharmingen), anti-CD303 (AC144, Miltenyi Biotec), anti-Foxp3 (259D, eBioscience), anti-CTLA-4 (BNI3, BD Biosciences) ...
Disrupted circadian rhythms in VIP and PHI deficeint mice
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Chen John J et al., In Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 2002
... The cells were then permeabilized in FoxP3 perm buffer (Biolegend Cat No ...
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.
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Aboody Karen S., In PLoS ONE, 1991
... Foxp3-FITC was purchased from ebioscience, primary antibodies for immunofluorescence ...
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