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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

Forkhead box P3

The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CD25, CAN, IL-10, CD8
Papers using Foxp3 antibodies
The Living Eye “Disarms” Uncommitted Autoreactive T Cells by Converting Them to Foxp3+ Regulatory Cells following Local Antigen Recognition
Gregerson Dale S. et al., In Frontiers in Immunology, 2011
... Foxp3-GFP and Foxp3-DTR/GFP transgenic mice on the B6 ...
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
Unutmaz Derya, In PLoS ONE, 2010
... FoxP3-FITC (eBioscience, San Diego, USA), ICOS-PE ...
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
Baumgrass Ria et al., In Frontiers in Immunology, 2006
... fixed and permeabilized using the FOXP3 staining buffer set (eBioscience) and stained with antibodies against FOXP3-FITC (eBioscience), IL-2-APC (BD), IL-4-PE (BD), ...
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
Han Xiaonan et al., In EMBO Molecular Medicine, 2006
... CD4, CD25 and Foxp3 were from eBioscience (San Diego, CA) ...
BAC to immunology – bacterial artificial chromosome-mediated transgenesis for targeting of immune cells
Freitas Antonio A., In PLoS ONE, 2006
... ; The Jackson Laboratory) and Foxp3 BAC transgenic mice expressing a human diphtheria ...
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Papers on Foxp3
Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals to Stabilize FOXP3 Protein Expression.
Wedderburn et al., London, United Kingdom. In J Immunol, 11 Dec 2015
UNASSIGNED: Although there is great interest in harnessing the immunosuppressive potential of FOXP3(+) regulatory T cells (Tregs) for treating autoimmunity, a sizeable knowledge gap exists regarding Treg fate in human disease.
CD20+ B cell depletion therapy suppresses murine CD8+ T cell-mediated immune thrombocytopenia (ITP).
Semple et al., Toronto, Canada. In Blood, 10 Dec 2015
This resulted in efficient Bdep in vivo, accompanied by significant increases in splenic and lymph node CD4(+) and CD8(+) T cells and proportional increases of FOXP3(+) in CD4(+) and CD8(+) T cells.
Insulin-Like Growth Factor (IGF)-1 modulates endothelial blood brain barrier function in ischemic middle-aged female rats.
Sohrabji et al., Bryan, United States. In Endocrinology, 10 Dec 2015
Mononuclear cells from the ischemic hemisphere were stained for CD4 or triple-labeled for CD4/CD25/FoxP3 and subject to flow analyses.
Regulatory T cells in cardiovascular diseases.
Zhang et al., Jinan, China. In Nat Rev Cardiol, 03 Dec 2015
The role of CD4(+)CD25(+)FOXP3(+) regulatory T (TREG) cells in the modulation of inflammation and immunity has received increasing attention.
Molecular Pathology of Adult T-Cell Leukemia/Lymphoma.
Ohshima, Kurume, Japan. In Oncology, 30 Nov 2015
ATLL cells express CD2, CD3, CD5, CD4, and CD25, as well as CCR4 and FoxP3 of the regulatory T-cell marker.
Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants.
Matarese et al., Napoli, Italy. In Nat Immunol, 30 Nov 2015
Human regulatory T cells (Treg cells) that develop from conventional T cells (Tconv cells) following suboptimal stimulation via the T cell antigen receptor (TCR) (induced Treg cells (iTreg cells)) express the transcription factor Foxp3, are suppressive, and display an active proliferative and metabolic state.
Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.
Cantor et al., Boston, United States. In Science, 16 Nov 2015
We report that impaired expression of the transcription factor (TF) Helios by FoxP3(+) CD4 and Qa-1-restricted CD8 T(regs) results in defective regulatory activity and autoimmunity in mice.
Deciphering the role of TRIB1 in regulatory T-cells.
Brouard et al., Nantes, France. In Biochem Soc Trans, 01 Nov 2015
We reported on the overexpression of tribbles-1 (TRIB1) in Tregs compared with their counterpart naive T-cells and that TRIB1 interacts with the master molecule of Tregs, forkhead box P3 (FOXP3), a transcription factor essential for Treg suppressive activity.
Helicobacter pylori Infection in Pediatrics.
Miele et al., Athens, Greece. In Helicobacter, Sep 2015
The host response of Treg cells with increases in FOXP3 and TGF-β1 combined with a reduction in IFN-γ by Teff cells may contribute to Helicobacter pylori susceptibility in children.
MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells.
Benoist et al., Boston, United States. In Science, Sep 2015
T regulatory cells that express the transcription factor Foxp3 (Foxp3(+) T(regs)) promote tissue homeostasis in several settings.
AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.
Jordan et al., Bethesda, United States. In Science, Aug 2015
We found that LRBA colocalized with CTLA4 in endosomal vesicles and that LRBA deficiency or knockdown increased CTLA4 turnover, which resulted in reduced levels of CTLA4 protein in FoxP3(+) regulatory and activated conventional T cells.
Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and triple-negative primary breast cancers.
Loibl et al., Rostock, Germany. In J Clin Oncol, Apr 2015
mRNA expression of immune-activating (CXCL9, CCL5, CD8A, CD80, CXCL13, IGKC, CD21) as well as immunosuppressive factors (IDO1, PD-1, PD-L1, CTLA4, FOXP3) was measured in 481 tumors.
Targeting Tuberculosis and HIV Infection-Specific Regulatory T Cells with MEK/ERK Signaling Pathway Inhibitors.
Tasken et al., Oslo, Norway. In Plos One, Dec 2014
The MEK/ERK signaling pathway is involved in regulation of the FoxP3 transcription factor, which directs a lineage-specific transcriptional program to define Tregs and control their suppressive function.
FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases.
Li et al., Shanghai, China. In Front Immunol, Dec 2014
CD4(+)CD25(+) regulatory T (Treg) cells play a pivotal role in the maintenance of immune homeostasis, where the X-linked master transcription factor forkhead box P3 (FOXP3) determines Treg cell development and function.
Regulatory T-Cell Development in the Human Thymus.
Sousa et al., Lisbon, Portugal. In Front Immunol, Dec 2014
The thymus generates a lineage-committed subset of regulatory T-cells (Tregs), best identified by the expression of the transcription factor FOXP3.
Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut.
von Boehmer et al., Boston, United States. In J Exp Med, 2012
binding of Smad3 to the foxp3 enhancer is dispensable for regulatory T cell development in newborn and adult mice with the exception of the gut
Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions.
Gorochov et al., Paris, France. In Ann Rheum Dis, 2012
Active and diffuse forms of sclerosis are associated with a FoxP3 signature.
Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms.
Hancock et al., Philadelphia, United States. In Sci Signal, 2012
Data indicate that although histone deacetylases HDAC6, HDAC9, and Sirt1 all deacetylated Foxp3, each protein had different effects on transcription factors that control expression of the gene encoding Foxp3.
Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
Aurora et al., Saint Louis, United States. In Plos One, 2011
Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
FoxP3⁺ regulatory CD4 T cells control the generation of functional CD8 memory.
Taoufik et al., Le Kremlin-Bicêtre, France. In Nat Commun, 2011
FoxP3 positive regulatory CD4 T cells control the generation of functional CD8 memory.
More papers using Foxp3 antibodies
FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.
Kretschmer Karsten et al., In Frontiers in Immunology, 2006
... ) mice on the C57BL/6 background, as well as Foxp3 bacterial artificial chromosome (BAC) transgenic mice expressing a Cre recombinase-GFP ...
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Zheng Song Guo, In PLoS ONE, 2004
... anti-CD86 (BU63, Serotec), anti-CD123 (9F5, BD Biosciences), anti-CD127 (HIL-7R-M21, BD Pharmingen), anti-CD303 (AC144, Miltenyi Biotec), anti-Foxp3 (259D, eBioscience), anti-CTLA-4 (BNI3, BD Biosciences) ...
Disrupted circadian rhythms in VIP and PHI deficeint mice
Chen John J et al., In Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 2002
... The cells were then permeabilized in FoxP3 perm buffer (Biolegend Cat No ...
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.
Aboody Karen S., In PLoS ONE, 1991
... Foxp3-FITC was purchased from ebioscience, primary antibodies for immunofluorescence ...
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