gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Dec 2014.

Forkhead box P3

Foxp3
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CD25, CAN, IL-10, CD8
Papers using Foxp3 antibodies
The Living Eye “Disarms” Uncommitted Autoreactive T Cells by Converting Them to Foxp3+ Regulatory Cells following Local Antigen Recognition
Supplier
Gregerson Dale S. et al., In Frontiers in Immunology, 2011
... Foxp3-GFP and Foxp3-DTR/GFP transgenic mice on the B6 ...
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
Supplier
Unutmaz Derya, In PLoS ONE, 2010
... FoxP3-FITC (eBioscience, San Diego, USA), ICOS-PE ...
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
Supplier
Baumgrass Ria et al., In Frontiers in Immunology, 2006
... fixed and permeabilized using the FOXP3 staining buffer set (eBioscience) and stained with antibodies against FOXP3-FITC (eBioscience), IL-2-APC (BD), IL-4-PE (BD), ...
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
Supplier
Han Xiaonan et al., In EMBO Molecular Medicine, 2006
... CD4, CD25 and Foxp3 were from eBioscience (San Diego, CA) ...
BAC to immunology – bacterial artificial chromosome-mediated transgenesis for targeting of immune cells
Supplier
Freitas Antonio A., In PLoS ONE, 2006
... ; The Jackson Laboratory) and Foxp3 BAC transgenic mice expressing a human diphtheria ...
more suppliers
Papers on Foxp3
Profound loss of intestinal Tregs in acutely SIV-infected neonatal macaques.
New
Veazey et al., United States. In J Leukoc Biol, 09 Jan 2015
Large numbers of FoxP3(+) T cells were found in all tissues in newborn macaques, which coexpressed high levels of CD25 and CD4, indicating that they were Tregs.
HMGB1 secretion during cervical carcinogenesis promotes the acquisition of a tolerogenic functionality by plasmacytoid dendritic cells.
New
Hubert et al., Liège, Belgium. In Int J Cancer, 09 Jan 2015
In parallel, we observed that (pre)neoplastic areas of the cervix are infiltrated by FoxP3(+) Treg cells which colocalize with pDCs.
Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients.
New
Malmegrim et al., Ribeirão Preto, Brazil. In Bone Marrow Transplant, 08 Jan 2015
AHSCT increased CD4(+)CD25(hi)FoxP3(+) regulatory T-cell counts and expression of CTLA-4 and GITR (glucocorticoid-induced TNFR) on CD4(+)CD25(hi) T cells.
Regulatory and effector T cells changes in remission and resistant state of childhood nephrotic syndrome.
New
Modi et al., Lucknow, India. In Indian J Nephrol, 30 Nov 2014
Peripheral blood CD4 + CD25 + FoxP3 + (Tregs), CD4 + IFN-γ(+) (Th1), and CD4 + IL-4 + (Th2) lymphocytes were analyzed in 22 steroid-sensitive NS (SSNS) patients in sustained remission, 21 steroid-resistant NS (SRNS) and 14 healthy controls.
Regulatory T-cells in autoimmune diseases: Challenges, controversies and-yet-unanswered questions.
Review
New
Longhi et al., London, United Kingdom. In Autoimmun Rev, 16 Nov 2014
Markers commonly used to define human Tregs in the research setting include high expression of CD25, FOXP3 positivity and low expression/negativity for CD127.
In vitro T-cell profile induced by BCG Moreau in healthy Brazilian volunteers.
New
Antas et al., In Hum Vaccin Immunother, Nov 2014
After 48 hours, CD4+ and CD8+ T cells were harvested from both groups and stained for PD-1/CD25/ FOXP3.
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.
New
Impact
Uzel et al., Bethesda, United States. In Science, Oct 2014
Whereas Ctla4 heterozygous mice have no obvious phenotype, human CTLA4 haploinsufficiency caused dysregulation of FoxP3(+) regulatory T (Treg) cells, hyperactivation of effector T cells, and lymphocytic infiltration of target organs.
The alarmin IL-33 promotes regulatory T-cell function in the intestine.
New
Impact
Powrie et al., Oxford, United Kingdom. In Nature, Oct 2014
FOXP3(+) regulatory T cells (Treg cells) are abundant in the intestine, where they prevent dysregulated inflammatory responses to self and environmental stimuli.
Post-translational modification networks regulating FOXP3 function.
Review
New
Coffer et al., Utrecht, Netherlands. In Trends Immunol, Aug 2014
Post-translational modifications (PTMs) can transiently alter the functionality of transcription factors, and recent evidence reveals that FOXP3 can be regulated by various PTMs including acetylation, ubiquitination, and phosphorylation.
The immunology of pregnancy: Regulatory T cells control maternal immune tolerance toward the fetus.
Review
New
Matarese et al., Napoli, Italy. In Immunol Lett, Aug 2014
Several functional studies have shown that unexplained infertility, miscarriage and pre-clampsia are often associated with deficit in Treg cell number and function while normal pregnancy selectively stimulates the accumulation of maternal forkhead-box-P3(+) (FoxP3(+)) CD4(+) Treg cells with fetal specificity.
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors.
New
Impact
Coukos et al., Philadelphia, United States. In Nat Med, Jun 2014
In these tumors, FasL expression was associated with scarce CD8(+) infiltration and a predominance of FoxP3(+) T regulatory (Treg) cells.
FOXP3 and scurfy: how it all began.
Review
New
Impact
Ziegler et al., Seattle, United States. In Nat Rev Immunol, May 2014
It has been 65 years since the scurfy mutation arose spontaneously in mice at the Oak Ridge National Laboratory in the United States, and it is 13 years since the molecular cloning of the forkhead box P3 (FOXP3) gene was reported.
FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS.
New
Impact
Issazadeh-Navikas et al., Copenhagen, Denmark. In Nat Med, Mar 2014
FoxA1(+) Treg cells develop primarily in the central nervous system in response to autoimmune inflammation, have a distinct transcriptional profile and are CD4(+)FoxA1(+)CD47(+)CD69(+)PD-L1(hi)FoxP3(-).
Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic Microenvironment.
Review
New
Cobbold et al., Oxford, United Kingdom. In Front Immunol, Dec 2013
The first is due to the up-regulation of multiple enzymes that consume essential amino acids, which are sensed in naïve T cells primarily via inhibition of the mechanistic target of rapamycin (mTOR) pathway, which in turn encourages their further differentiation into FOXP3(+) Treg cells.
The potential mechanistic link between allergy and obesity development and infant formula feeding.
Review
New
Melnik, Osnabrück, Germany. In Allergy Asthma Clin Immunol, Dec 2013
Overactivated mTORC1 enhances S6K1-mediated adipocyte differentiation, but negatively regulates growth and differentiation of FoxP3(+) regulatory T-cells (Tregs), which are deficient in atopic individuals.
Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut.
GeneRIF
von Boehmer et al., Boston, United States. In J Exp Med, 2012
binding of Smad3 to the foxp3 enhancer is dispensable for regulatory T cell development in newborn and adult mice with the exception of the gut
Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions.
GeneRIF
Gorochov et al., Paris, France. In Ann Rheum Dis, 2012
Active and diffuse forms of sclerosis are associated with a FoxP3 signature.
Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms.
GeneRIF
Hancock et al., Philadelphia, United States. In Sci Signal, 2012
Data indicate that although histone deacetylases HDAC6, HDAC9, and Sirt1 all deacetylated Foxp3, each protein had different effects on transcription factors that control expression of the gene encoding Foxp3.
Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
GeneRIF
Aurora et al., Saint Louis, United States. In Plos One, 2011
Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
FoxP3⁺ regulatory CD4 T cells control the generation of functional CD8 memory.
GeneRIF
Taoufik et al., Le Kremlin-Bicêtre, France. In Nat Commun, 2011
FoxP3 positive regulatory CD4 T cells control the generation of functional CD8 memory.
More papers using Foxp3 antibodies
FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.
Supplier
Kretschmer Karsten et al., In Frontiers in Immunology, 2006
... ) mice on the C57BL/6 background, as well as Foxp3 bacterial artificial chromosome (BAC) transgenic mice expressing a Cre recombinase-GFP ...
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Supplier
Zheng Song Guo, In PLoS ONE, 2004
... anti-CD86 (BU63, Serotec), anti-CD123 (9F5, BD Biosciences), anti-CD127 (HIL-7R-M21, BD Pharmingen), anti-CD303 (AC144, Miltenyi Biotec), anti-Foxp3 (259D, eBioscience), anti-CTLA-4 (BNI3, BD Biosciences) ...
Disrupted circadian rhythms in VIP and PHI deficeint mice
Supplier
Chen John J et al., In Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 2002
... The cells were then permeabilized in FoxP3 perm buffer (Biolegend Cat No ...
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.
Supplier
Aboody Karen S., In PLoS ONE, 1991
... Foxp3-FITC was purchased from ebioscience, primary antibodies for immunofluorescence ...
share on facebooktweetadd +1mail to friends