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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Forkhead box P3

Foxp3
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CD25, CAN, CD8, IL-10
Papers using Foxp3 antibodies
The Living Eye “Disarms” Uncommitted Autoreactive T Cells by Converting Them to Foxp3+ Regulatory Cells following Local Antigen Recognition
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Gregerson Dale S. et al., In Frontiers in Immunology, 2011
... Foxp3-GFP and Foxp3-DTR/GFP transgenic mice on the B6 ...
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
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Unutmaz Derya, In PLoS ONE, 2010
... FoxP3-FITC (eBioscience, San Diego, USA), ICOS-PE ...
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
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Baumgrass Ria et al., In Frontiers in Immunology, 2006
... fixed and permeabilized using the FOXP3 staining buffer set (eBioscience) and stained with antibodies against FOXP3-FITC (eBioscience), IL-2-APC (BD), IL-4-PE (BD), ...
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
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Han Xiaonan et al., In EMBO Molecular Medicine, 2006
... CD4, CD25 and Foxp3 were from eBioscience (San Diego, CA) ...
BAC to immunology – bacterial artificial chromosome-mediated transgenesis for targeting of immune cells
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Freitas Antonio A., In PLoS ONE, 2006
... ; The Jackson Laboratory) and Foxp3 BAC transgenic mice expressing a human diphtheria ...
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Papers on Foxp3
Elevated Levels of Serum IL-12 and IL-18 are Associated with Lower Frequencies of CD4(+)CD25 (high)FOXP3 (+) Regulatory T cells in Young Patients with Type 1 Diabetes.
New
Myśliwska et al., Gdańsk, Poland. In Inflammation, 31 Oct 2014
The overproduction of proinflammatory mediators is controlled by specialized T cell subset, namely regulatory T cells that express FOXP3 transcription factor.
New regulatory CD19(+)CD25(+) B-cell subset in clinically isolated syndrome and multiple sclerosis relapse. Changes after glucocorticoids.
New
Sánchez-Ramón et al., Madrid, Spain. In J Neuroimmunol, Jun 2014
We identified novel perforin-expressing regulatory B-cells (BReg) in patients with clinically isolated syndrome, significantly enriched within the cerebrospinal fluid when compared to peripheral blood, of memory B cell phenotype (CD19(+)CD25(+), CD19(+)CD25(+)FoxP3(+) and CD19(+)FoxP3(+), p=0.007, p=0.06 and p=0.03, respectively).
The intratumoural subsite and relation of CD8(+) and FOXP3(+) T lymphocytes in colorectal cancer provide important prognostic clues.
New
Palmqvist et al., Umeå, Sweden. In Br J Cancer, Jun 2014
BACKGROUND: To find improved tools for prognostic evaluation in patients with colorectal cancer (CRC), we have analysed how infiltration of cytotoxic T lymphocytes (CD8(+)) and regulatory T lymphocytes (FoxP3(+)) correlates to prognosis, not only according to quantity and relation, but also to subsite within tumours of different molecular characteristics (microsatellite instability and CpG island methylator phenotype status).
The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations.
New
FANTOM consortium et al., Regensburg, Germany. In Blood, May 2014
CD4(+)CD25(+)FOXP3(+) human regulatory T cells (Tregs) are essential for self-tolerance and immune homeostasis.
FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS.
New
Impact
Issazadeh-Navikas et al., Copenhagen, Denmark. In Nat Med, Mar 2014
FoxA1(+) Treg cells develop primarily in the central nervous system in response to autoimmune inflammation, have a distinct transcriptional profile and are CD4(+)FoxA1(+)CD47(+)CD69(+)PD-L1(hi)FoxP3(-).
Homeostatic control of regulatory T cell diversity.
New
Impact
Gray et al., Leuven, Belgium. In Nat Rev Immunol, Mar 2014
Dynamic homeostatic processes preserve the number of forkhead box P3-expressing (FOXP3(+)) TReg cells within a healthy range, with high rates of cell division being offset by apoptosis under steady-state conditions.
Autophagy in non-small cell lung carcinogenesis: A positive regulator of antitumor immunosurveillance.
Review
New
Kroemer et al., Vienna, Austria. In Autophagy, Mar 2014
The accelerated oncogenesis of autophagy-deficient tumors developing in KRas;Atg5(fl/fl) mice (as compared with autophagy-competent KRas;Atg5(fl/+) control tumors) correlates with an increased infiltration by FOXP3(+) regulatory T cells (Tregs).
A125: Immunomodulatory Factors Produced by Mesenchymal Stem Cells After in vitro Priming with Danger Signals.
New
Jones et al., Cleveland, United States. In Arthritis Rheumatol, Mar 2014
CCR-8 is a known biomarker identifying CD4(+) memory T-cells enriched for FoxP3(+) T-regulatory cells and is involved in delivery of immunosuppression.
Regulatory T cell proliferative potential is impaired in human autoimmune disease.
New
Impact
Matarese et al., Napoli, Italy. In Nat Med, Jan 2014
This is associated with decreased expression of the forkhead box P3 (FoxP3) 44- and 47-kDa splicing forms, overactivation of S6 ribosomal protein (a downstream target of the mammalian target of rapamycin, mTOR) and altered activity of the cyclin-dependent kinase inhibitor p27 (p27(kip1)) and extracellular signal-related kinases 1 and 2 (ERK1/2).
Epigenetic regulation in allergic diseases and related studies.
Review
New
Hung et al., Kao-hsiung, Taiwan. In Asia Pac Allergy, Jan 2014
Epigenetic marks (DNA methylation, modifications of histone tails or noncoding RNAs) work with other components of the cellular regulatory machinery to control the levels of expressed genes, and several allergy- and asthma-related genes have been found to be susceptible to epigenetic regulation, including genes important to T-effector pathways (IFN-γ, interleukin [IL] 4, IL-13, IL-17) and T-regulatory pathways (FoxP3).
Regulatory T cells as adjuvant target for enhancing the viral disease vaccine efficacy.
Review
New
Bayry, Paris, France. In Virusdisease, Jan 2014
CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) are critical for immune homeostasis and tolerance.
FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells.
New
Impact
Sa et al., Calcutta, India. In Immunity, Jan 2014
FoxP3, a lineage-specification factor, executes its multiple activities mostly through transcriptional regulation of target genes.
Molecular markers for breast cancer: prediction on tumor behavior.
Review
New
Watanabe et al., Londrina, Brazil. In Dis Markers, Dec 2013
Furthermore, this review shows the new molecular targets in breast cancer: CXCR4, caveolin, miRNA, and FOXP3, as promising candidates for future development of effective and targeted therapies, also with lower toxicity.
A degrading view of regulatory T cells.
New
Impact
O'Shea et al., Bethesda, United States. In Immunity, Sep 2013
and Chen et al. in this issue of Immunity provide evidence for previously unrecognized players that regulate FOXP3 degradation.
Searching for the Achilles Heel of FOXP3.
Review
Lasarte et al., Pamplona, Spain. In Front Oncol, 2012
FOXP3 is a multifaceted transcription factor with a major role in the control of immune homeostasis mediated by T regulatory cells (Treg).
Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut.
GeneRIF
von Boehmer et al., Boston, United States. In J Exp Med, 2012
binding of Smad3 to the foxp3 enhancer is dispensable for regulatory T cell development in newborn and adult mice with the exception of the gut
Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions.
GeneRIF
Gorochov et al., Paris, France. In Ann Rheum Dis, 2012
Active and diffuse forms of sclerosis are associated with a FoxP3 signature.
Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms.
GeneRIF
Hancock et al., Philadelphia, United States. In Sci Signal, 2012
Data indicate that although histone deacetylases HDAC6, HDAC9, and Sirt1 all deacetylated Foxp3, each protein had different effects on transcription factors that control expression of the gene encoding Foxp3.
Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
GeneRIF
Aurora et al., Saint Louis, United States. In Plos One, 2011
Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
FoxP3⁺ regulatory CD4 T cells control the generation of functional CD8 memory.
GeneRIF
Taoufik et al., Le Kremlin-Bicêtre, France. In Nat Commun, 2011
FoxP3 positive regulatory CD4 T cells control the generation of functional CD8 memory.
More papers using Foxp3 antibodies
FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.
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Kretschmer Karsten et al., In Frontiers in Immunology, 2006
... ) mice on the C57BL/6 background, as well as Foxp3 bacterial artificial chromosome (BAC) transgenic mice expressing a Cre recombinase-GFP ...
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Supplier
Zheng Song Guo, In PLoS ONE, 2004
... anti-CD86 (BU63, Serotec), anti-CD123 (9F5, BD Biosciences), anti-CD127 (HIL-7R-M21, BD Pharmingen), anti-CD303 (AC144, Miltenyi Biotec), anti-Foxp3 (259D, eBioscience), anti-CTLA-4 (BNI3, BD Biosciences) ...
Disrupted circadian rhythms in VIP and PHI deficeint mice
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Chen John J et al., In Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 2002
... The cells were then permeabilized in FoxP3 perm buffer (Biolegend Cat No ...
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.
Supplier
Aboody Karen S., In PLoS ONE, 1991
... Foxp3-FITC was purchased from ebioscience, primary antibodies for immunofluorescence ...
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