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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Aug 2015.

Forkhead box P3

Foxp3
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD4, CD25, CAN, IL-10, CD8
Papers using Foxp3 antibodies
The Living Eye “Disarms” Uncommitted Autoreactive T Cells by Converting Them to Foxp3+ Regulatory Cells following Local Antigen Recognition
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Gregerson Dale S. et al., In Frontiers in Immunology, 2011
... Foxp3-GFP and Foxp3-DTR/GFP transgenic mice on the B6 ...
Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells.
Supplier
Unutmaz Derya, In PLoS ONE, 2010
... FoxP3-FITC (eBioscience, San Diego, USA), ICOS-PE ...
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
Supplier
Baumgrass Ria et al., In Frontiers in Immunology, 2006
... fixed and permeabilized using the FOXP3 staining buffer set (eBioscience) and stained with antibodies against FOXP3-FITC (eBioscience), IL-2-APC (BD), IL-4-PE (BD), ...
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
Supplier
Han Xiaonan et al., In EMBO Molecular Medicine, 2006
... CD4, CD25 and Foxp3 were from eBioscience (San Diego, CA) ...
BAC to immunology – bacterial artificial chromosome-mediated transgenesis for targeting of immune cells
Supplier
Freitas Antonio A., In PLoS ONE, 2006
... ; The Jackson Laboratory) and Foxp3 BAC transgenic mice expressing a human diphtheria ...
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Papers on Foxp3
Exclusive Transduction of Human CD4+ T Cells upon Systemic Delivery of CD4-Targeted Lentiviral Vectors.
New
Buchholz et al., Langen, Germany. In J Immunol, 31 Aug 2015
The potential for in vivo delivery of the FOXP3 gene was also demonstrated, making CD4-LV a powerful tool for inducible regulatory T cell generation.
Foxp3(+) regulatory T cells are expanded in severe atopic dermatitis patients.
New
Werfel et al., Hannover, Germany. In Allergy, 30 Aug 2015
The detection of Tregs by FOXP3-expression may lead to false positive results since activated T cells without regulatory function may transiently upregulate this transcription factor.
Nonchimeric HLA-Identical Renal Transplant Tolerance: Regulatory Immunophenotypic/Genomic Biomarkers.
New
Miller et al., Chicago, United States. In Am J Transplant, 30 Aug 2015
We now add seven new subjects (two operationally tolerant), and demonstrate time-dependent increases of circulating CD4(+) CD25(+++) CD127(-) FOXP3(+) Tregs versus losses of Tregs in nontolerant subjects (p < 0.001).
Natural variation in IL-2 sensitivity influences regulatory T cell frequency and function in individuals with long-standing type 1 diabetes.
New
Tree et al., San Diego, United States. In Diabetes, 29 Aug 2015
UNASSIGNED: Defective immune homeostasis in the balance between FOXP3(+) regulatory T cells (Tregs) and effector T cells is a likely contributing factor in the loss of self-tolerance observed in type 1 diabetes (T1D).
AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy.
New
Impact
Jordan et al., Bethesda, United States. In Science, 24 Aug 2015
We found that LRBA colocalized with CTLA4 in endosomal vesicles and that LRBA deficiency or knockdown increased CTLA4 turnover, which resulted in reduced levels of CTLA4 protein in FoxP3(+) regulatory and activated conventional T cells.
Immune response regulation in the tumor microenvironment by hypoxia.
Review
New
Melero et al., Pamplona, Spain. In Semin Oncol, Jun 2015
Importantly, in the tumor microenvironment the hypoxia response modulates the expression levels for important molecular targets in immunotherapy such as CD137, OX-40, FOXP3, and PD-L1.
Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and triple-negative primary breast cancers.
New
Impact
Loibl et al., Rostock, Germany. In J Clin Oncol, Apr 2015
mRNA expression of immune-activating (CXCL9, CCL5, CD8A, CD80, CXCL13, IGKC, CD21) as well as immunosuppressive factors (IDO1, PD-1, PD-L1, CTLA4, FOXP3) was measured in 481 tumors.
Role and species-specific expression of colon T cell homing receptor GPR15 in colitis.
New
Impact
Habtezion et al., Stanford, United States. In Nat Immunol, Feb 2015
The TH2 transcriptional activator GATA-3 and the Treg-associated transcriptional repressor FOXP3 robustly bind human, but not mouse, GPR15 enhancer sequences, correlating with receptor expression.
Expression of Granulysin and FOXP3 in Cutaneous T Cell Lymphoma and Sezary Syndrome.
New
Wasfy et al., Ţanţā, Egypt. In Asian Pac J Cancer Prev, Dec 2014
AIM: The present study aimed to investigate the expression of granulysin and FOXP3 in mycosis fungoides (MF), its precursor lesion large plaque parapsoriasis and its leukemic form Sezary syndrome (SS).
Early-onset autoimmune disease as a manifestation of primary immunodeficiency.
Review
New
Coutinho et al., São Paulo, Brazil. In Front Immunol, Dec 2014
IPEX (due to FOXP3 mutation leading to Treg cell deficiency), usually appearing in the first months of life, was recently observed in miscarried fetuses with hydrops who presented with CD3+ infiltrating lymphocytes in the pancreas.
Glucocorticoid-induced tumour necrosis factor receptor-related protein: a key marker of functional regulatory T cells.
Review
New
Riccardi et al., Perugia, Italy. In J Immunol Res, Dec 2014
Furthermore, some Treg subsets including Tr1 cells express either low or no classical Treg markers (e.g., FoxP3 and CD25) and do express GITR.
Vitamin D Actions on CD4(+) T Cells in Autoimmune Disease.
Review
New
Nashold et al., Madison, United States. In Front Immunol, Dec 2014
Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3(+)CD4(+) T-regulatory cell and CD4(+) T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch.
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4.
New
Impact
Uzel et al., Bethesda, United States. In Science, Oct 2014
Whereas Ctla4 heterozygous mice have no obvious phenotype, human CTLA4 haploinsufficiency caused dysregulation of FoxP3(+) regulatory T (Treg) cells, hyperactivation of effector T cells, and lymphocytic infiltration of target organs.
The alarmin IL-33 promotes regulatory T-cell function in the intestine.
New
Impact
Powrie et al., Oxford, United Kingdom. In Nature, Oct 2014
FOXP3(+) regulatory T cells (Treg cells) are abundant in the intestine, where they prevent dysregulated inflammatory responses to self and environmental stimuli.
Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut.
GeneRIF
von Boehmer et al., Boston, United States. In J Exp Med, 2012
binding of Smad3 to the foxp3 enhancer is dispensable for regulatory T cell development in newborn and adult mice with the exception of the gut
Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions.
GeneRIF
Gorochov et al., Paris, France. In Ann Rheum Dis, 2012
Active and diffuse forms of sclerosis are associated with a FoxP3 signature.
Histone deacetylases 6 and 9 and sirtuin-1 control Foxp3+ regulatory T cell function through shared and isoform-specific mechanisms.
GeneRIF
Hancock et al., Philadelphia, United States. In Sci Signal, 2012
Data indicate that although histone deacetylases HDAC6, HDAC9, and Sirt1 all deacetylated Foxp3, each protein had different effects on transcription factors that control expression of the gene encoding Foxp3.
Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
GeneRIF
Aurora et al., Saint Louis, United States. In Plos One, 2011
Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
FoxP3⁺ regulatory CD4 T cells control the generation of functional CD8 memory.
GeneRIF
Taoufik et al., Le Kremlin-Bicêtre, France. In Nat Commun, 2011
FoxP3 positive regulatory CD4 T cells control the generation of functional CD8 memory.
Role of regulatory T cells in rheumatoid arthritis: facts and hypothesis.
Review
Gerli et al., Perugia, Italy. In Auto Immun Highlights, 2010
Although the intracellular transcription factor FoxP3 is thought to be the master regulator of Treg cell function, a number of other molecules expressed on the cell surface have been proposed for the identification of Treg cells.
More papers using Foxp3 antibodies
FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.
Supplier
Kretschmer Karsten et al., In Frontiers in Immunology, 2006
... ) mice on the C57BL/6 background, as well as Foxp3 bacterial artificial chromosome (BAC) transgenic mice expressing a Cre recombinase-GFP ...
IFN-g production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo
Supplier
Zheng Song Guo, In PLoS ONE, 2004
... anti-CD86 (BU63, Serotec), anti-CD123 (9F5, BD Biosciences), anti-CD127 (HIL-7R-M21, BD Pharmingen), anti-CD303 (AC144, Miltenyi Biotec), anti-Foxp3 (259D, eBioscience), anti-CTLA-4 (BNI3, BD Biosciences) ...
Disrupted circadian rhythms in VIP and PHI deficeint mice
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Chen John J et al., In Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 2002
... The cells were then permeabilized in FoxP3 perm buffer (Biolegend Cat No ...
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.
Supplier
Aboody Karen S., In PLoS ONE, 1991
... Foxp3-FITC was purchased from ebioscience, primary antibodies for immunofluorescence ...
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