Understanding Language from a Genomic Perspective.
Nijmegen, Netherlands. In Annu Rev Genet, Dec 2015
Heritable disorders offer a gateway into biological underpinnings, as illustrated by the discovery that FOXP2 disruptions cause a rare form of speech and language impairment.
Tuftsin-derived T-peptide prevents cellular immunosuppression and improves survival rate in septic mice.
Tianjin, China. In Sci Rep, 2014
When CD4(+)CD25(+) Tregs were treated with T-peptide for 24 hours, and co-cultured with normal CD4(+)CD25(-) T cells, the suppressive ability of CD4(+)CD25(+) Tregs on CD4(+)CD25(-) T cells was significantly lowered, along with decreased expression in forkhead/winged helix transcription factor p-3 (Foxp-3) as well as cytotoxic T lymphocyte-associated antigen (CTLA)-4, and secretion of transforming growth factor (TGF)-β.
Why we can talk, debate, and change our minds: neural circuits, basal ganglia operations, and transcriptional factors.
Providence, United States. In Behav Brain Sci, 2014
Basal ganglia operations, enhanced by mutations on FOXP2, confer human motor-control, linguistic, and cognitive capabilities.
Brain mechanisms of acoustic communication in humans and nonhuman primates: an evolutionary perspective.
München, Germany. In Behav Brain Sci, 2014
Furthermore, neurobiological and paleoanthropological data point at a two-stage model of the phylogenetic evolution of this crucial prerequisite of spoken language: (i) monosynaptic refinement of the projections of motor cortex to the brainstem nuclei that steer laryngeal muscles, presumably, as part of a "phylogenetic trend" associated with increasing brain size during hominin evolution; (ii) subsequent vocal-laryngeal elaboration of cortico-basal ganglia circuitries, driven by human-specific FOXP2 mutations.;>This
Environments organize the verbal brain.
Baltimore, United States. In Behav Brain Sci, 2014
FOXP2 expression in the evolution of language derives from its role in allowing vocal articulation that is sensitive to its consequences.
What can mice tell us about Foxp2 function?
Lisbon, Portugal. In Curr Opin Neurobiol, 2014
Disruptions of the FOXP2 gene cause a rare speech and language disorder, a discovery that has opened up novel avenues for investigating the relevant neural pathways.
The role of vitamin d in autoimmune hepatitis.
Westminster, United States. In J Clin Med Res, 2013
Genetic studies have provided the opportunity to determine which proteins link vitamin D to AIH pathology, namely, the major histocompatibility complex class II molecules, vitamin D receptors, toll-like receptors, cytotoxic T lymphocyte antigen-4, cytochrome P450 CYP2D6, regulatory T cells (Tregs) and the forkhead/winged helix transcription factor 3. Vitamin D also exerts its effect on AIH through non-genomic factors, namely, mitogen-activated protein kinase signaling pathways, γδT cells, interferon-gamma nitric oxide synthase, and reactive oxygen stress.