gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Forkhead box P1

FOXP1
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: bcl-6, MUM1, bcl-2, HAD, FOXP2
Papers on FOXP1
Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1.
New
Tucker et al., Austin, United States. In Proc Natl Acad Sci U S A, Feb 2016
UNASSIGNED: High expression of the forkhead box P1 (FOXP1) transcription factor distinguishes the aggressive activated B cell (ABC) diffuse large B-cell lymphoma (DLBCL) subtype from the better prognosis germinal center B-cell (GCB)-DLBCL subtype and is highly correlated with poor outcomes.
EBV-Positive and EBV-Negative Posttransplant Diffuse Large B Cell Lymphomas Have Distinct Genomic and Transcriptomic Features.
New
Wlodarska et al., Leuven, Belgium. In Am J Transplant, Feb 2016
Our data indicate that the FOXP1 oncogene and the tumor suppressor CDKNA2 implicated in EBV(-) DLBCL, do not play a critical role in the pathogenesis of EBV(+) PT-DLBCL.
A genome-wide association study of pulmonary tuberculosis in Morocco.
New
Abel et al., Rabat, Morocco. In Hum Genet, Feb 2016
In the combined sample including 556 PTB subjects and 650 controls these four SNPs showed suggestive association (2 × 10(-6) < p < 4  × 10(-5)): rs358793 and rs17590261 were intergenic, while rs6786408 and rs916943 were located in introns of FOXP1 and AGMO, respectively.
Intrafollicular Epstein-Barr virus-positive large B cell lymphoma. A variant of "germinotropic" lymphoproliferative disorder.
New
Facchetti et al., Brescia, Italy. In Virchows Arch, Feb 2016
Lymph nodes showed an effaced nodular architecture with abnormal B follicles colonized by EBV+ large, pleomorphic atypical cells, including Reed-Sternberg-like cells, showing an activated B cell phenotype (CD10-FOXP1-Bcl6-IRF4+ or CD10-FOXP1+Bcl6+IRF4+) and intense expression of CD30.
Identification of genomic aberrations in hemangioblastoma by droplet digital PCR and SNP microarray highlights novel candidate genes and pathways for pathogenesis.
New
Toren et al., Tel Aviv-Yafo, Israel. In Bmc Genomics, Dec 2015
CONCLUSIONS: Our findings provide the first high-resolution genome-wide view of chromosomal changes in hemangioblastoma and identify 23 candidate genes: EGFR, PRDM16, PTPN11, HOXD11, HOXD13, FLT3, PTCH, FGFR1, FOXP1, GPC3, HOXC13, HOXC11, MKL1, CHEK2, IRF4, GPHN, IKZF1, RB1, HOXA9, and micro RNA, such as hsa-mir-196a-2 for hemangioblastoma pathogenesis.
Novel Biomarker Signature That May Predict Aggressive Disease in African American Men With Prostate Cancer.
New
Impact
Schaeffer et al., Philadelphia, United States. In J Clin Oncol, Oct 2015
FOXP1 (P = .041),
MicroRNAs in B-cell lymphomas: how a complex biology gets more complex.
Review
New
Mraz et al., Brno, Czech Republic. In Leukemia, May 2015
We focus on miR-contribution to the regulation of important signalling pathways (such as NF-κB, PI3K/AKT and TGF-β), BCR signalling and its modulators (such as PTEN, SHIP-1, ZAP-70, GAB1 and BTK), anti- and pro-apoptotic proteins (such as BCL2, MCL1, TCL1, BIM, p53 and SIRT1) and transcription factors (such as MYC, MYB, PU.1, FOXP1 and BCL6).
Targeting foxp1 for reinstating anticancer immunosurveillance.
Impact
Kroemer et al., Villejuif, France. In Immunity, 2014
(2014) reveal that tumor-derived TGF-β deactivates antitumor CD8(+) T cell responses through T cell upregulation of the FoxP1 transcription factor.
Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.
Impact
Conejo-Garcia et al., Philadelphia, United States. In Immunity, 2014
Here we have characterized a common mechanism of T cell unresponsiveness in cancer driven by the upregulation of the transcription factor Forkhead box protein P1 (Foxp1), which prevents CD8⁺ T cells from proliferating and upregulating Granzyme-B and interferon-γ in response to tumor antigens.
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
Impact
Vaughan et al., Seattle, United States. In Nat Genet, 2013
A third is at 3p14 (rs2687201: P = 5.5 × 10(-9)) near the transcription factor FOXP1, which regulates esophageal development.
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming.
Impact
Blencowe et al., Toronto, Canada. In Nature, 2013
Among the MBNL-regulated events is an ES-cell-specific alternative splicing switch in the forkhead family transcription factor FOXP1 that controls pluripotency.
Cancer genetics and genomics of human FOX family genes.
Review
Katoh et al., Tokyo, Japan. In Cancer Lett, 2013
FOXP1 is upregulated as a result of gene fusion or amplification in DLBCL and MALT lymphoma and also repression of miRNAs, such as miR-1, miR-34a and miR-504.
Azidothymidine is effective against human multiple myeloma: a new use for an old drug?
Review
Bydlowski et al., São Paulo, Brazil. In Anticancer Agents Med Chem, 2013
AZT up-regulated the expression of tumor suppressor gene FOXP1 and the pro-apoptotic genes encoding BID, Bcl-10, and caspase-8.
FOXP1 and estrogen signaling in breast cancer.
Review
Inoue et al., Saitama, Japan. In Vitam Horm, 2012
Interestingly, immunohistochemical analysis of breast cancer specimens has revealed that nuclear immunoreactivities of FOXP1 as well as those of FOXA1 are positively correlated with hormone receptor status, including ERα and progesterone receptor.
Forkhead box P1 overexpression and its clinicopathologic significance in peripheral T-cell lymphoma, not otherwise specified.
GeneRIF
Yamada et al., Nagoya, Japan. In Hum Pathol, 2012
forkhead box P1 overexpression was associated with an improved overall survival of the patients with peripheral T-cell lymphoma, not otherwise specified
Association of double-positive FOXA1 and FOXP1 immunoreactivities with favorable prognosis of tamoxifen-treated breast cancer patients.
GeneRIF
Inoue et al., Saitama, Japan. In Horm Cancer, 2012
Double-positive immunoreactivities of FOXA1 and FOXP1 were significantly associated with a favorable prognosis for the relapse-free and overall survival in with tamoxifen-treated breast cancer.
High expression of FoxP1 is associated with improved survival in patients with non-small cell lung cancer.
GeneRIF
Huang et al., Nantong, China. In Am J Clin Pathol, 2012
Expression of FoxP1 messenger RNA (mRNA) and protein was significantly higher in NonSmall Cell Lung Carcinoma tissue than in corresponding peritumoral tissue (P = .013 and P < .001, respectively).
Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.
GeneRIF
Morrisey et al., Philadelphia, United States. In Development, 2012
Loss of Foxp1/4 in the developing lung and in postnatal secretory epithelium leads to ectopic activation of the goblet cell fate program, in part, through de-repression of the protein disulfide isomerase anterior gradient 2 (Agr2).
Prognostic significance of FOXP1 as an oncogene in hepatocellular carcinoma.
GeneRIF
Huang et al., Nantong, China. In J Clin Pathol, 2012
These results support a role for FOXP1 as an oncogene in hepatocellular carcinoma.
The role of the FOXP family of transcription factors in ASD.
Review
Konopka et al., Dallas, United States. In Dis Markers, 2011
The FOXP family of genes includes three genes expressed in the central nervous system: FOXP1, FOPX2, and FOXP4.
share on facebooktweetadd +1mail to friends