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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Forkhead box O1

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Akt, Insulin, V1a, CAN, PI3K
Papers using FOXO1 antibodies
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
Bozza Patricia T., In PLoS ONE, 2008
... Antibodies to eIF4E-BP1, eIF4G1, p53, FoxO1, PGC1α, and eIF2α were purchased form Santa Cruz Biotechnology (Santa Cruz, CA, USA.) ...
Signalling to translation: how signal transduction pathways control the protein synthetic machinery
Takenaka Asako et al., In Journal of Clinical Biochemistry and Nutrition, 2006
... Anti IRS-1, anti-IRS-2, anti-phosphotyrosine (p-Tyr), anti-FKHR, and secondary antibodies for immunoblotting were purchased from Santa Cruz Biotechnology Inc ...
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation
Itoh Hiroshi et al., In The EMBO Journal, 2004
... Sigma; anti-cMyc (9E10), anti-FOXO1 (H128), anti-PGC-1 (H300), and anti-GST (Z-5) from Santa Cruz Biotechnology; and anti-phospho-FOXO1 (pT24), and anti-acetylated lysine polyclonal antibodies from Cell Signaling Technology ...
Regulation of insulin-like growth factor–dependent myoblast differentiation by Foxo forkhead transcription factors
Accili Domenico et al., In The Journal of Cell Biology, 2001
... , P19, and RD cells from the American Type Culture Collection, anti- Foxo1 antibodies from Santa Cruz Biotechnology, Inc., anti-HA antibody 12CA5 ...
Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation.
Gromoll Joerg, In PLoS ONE, 1999
... (M19; sc-6004), and p27 (C-19; sc-528) were procured from Santa Cruz Biotechnology Inc., CA and Anti-FKHR (#9462) from Cell Signaling Technology, Beverly, MA ...
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Papers on FOXO1
Leptin signalling pathways in hypothalamic neurons.
Kim et al., Seoul, South Korea. In Cell Mol Life Sci, Feb 2016
The signaling pathways known to mediate the actions of leptin include JAK-STAT signaling, PI3K-Akt-FoxO1 signaling, SHP2-ERK signaling, AMPK signaling, and mTOR-S6K signaling.
FOXO1 couples metabolic activity and growth state in the vascular endothelium.
Potente et al., Bad Nauheim, Germany. In Nature, Feb 2016
Here we report that the forkhead box O (FOXO) transcription factor FOXO1 is an essential regulator of vascular growth that couples metabolic and proliferative activities in ECs.
Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling.
Tosini et al., Atlanta, United States. In Invest Ophthalmol Vis Sci, Feb 2016
Protein kinase B (AKT) and forkhead box O (FOXO1) were assessed by Western blotting and immunohistochemistry. RESULTS: The number of nuclei in the ONL was significantly reduced in C3Hf+/+, MT1-/-, and MT2-/- mice at 18 months of age with respect to 3-month-old animals.
Enhanced cytotoxic T-cell function and inhibition of tumor progression by Mst1 deficiency.
Kinashi et al., Ōsaka, Japan. In Febs Lett, Jan 2016
The data suggest that Mst1 inhibits cytotoxicity via T-bet suppression by FoxO1 and FoxO3a.
The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program.
Dalla-Favera et al., New York City, United States. In Immunity, Jan 2016
In this study we show that FOXO1 transcription factor expression was restricted to the GC DZ and was required for DZ formation, since its absence in mice led to the loss of DZ gene programs and the formation of LZ-only GCs.
PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones.
Rajewsky et al., Berlin, Germany. In Immunity, Jan 2016
We show here abundant nuclear FOXO1 expression in the proliferative compartment of the germinal center (GC), its dark zone (DZ), and PI3K activity, downregulating FOXO1, in the light zone (LZ), where cells are selected for further differentiation.
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity.
Link et al., Faro, Portugal. In Aging Cell, Jan 2016
Studies have consistently revealed FOXO (Forkhead box O) transcription factors as important determinants in aging and longevity.
N-Acetylcysteine Restores Sevoflurane Postconditioning Cardioprotection against Myocardial Ischemia-Reperfusion Injury in Diabetic Rats.
Xia et al., Guangzhou, China. In J Diabetes Res, Dec 2015
Diabetes showed reduction of cardiac STAT3 activation (p-STAT3) and adiponectin with concomitantly increase of FoxO1 and CD36, which associated with reduced sevo-postC cardioprotection.
Chronic Uridine Administration Induces Fatty Liver and Pre-Diabetic Conditions in Mice.
Le et al., Las Vegas, United States. In Plos One, Dec 2015
We report that uridine administration was associated with O-GlcNAc modification of FOXO1, increased gluconeogenesis, reduced insulin signaling activity, and reduced expression of a liver-specific fatty acid binding protein FABP1.
FOXO1 and GSK-3β Are Main Targets of Insulin-Mediated Myogenesis in C2C12 Muscle Cells.
Orzechowski et al., Warsaw, Poland. In Plos One, Dec 2015
These indices focus on the roles of insulin, glycogen synthase kinase 3 beta (GSK-3β) and forkhead box protein O1 (FOXO1) on myogenesis using a combination of treatments and inhibitors.
Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry.
Weigert et al., München, Germany. In Lancet Oncol, Sep 2015
FINDINGS: We established a clinicogenetic risk model (termed m7-FLIPI) that included the mutation status of seven genes (EZH2, ARID1A, MEF2B, EP300, FOXO1, CREBBP, and CARD11), the Follicular Lymphoma International Prognostic Index (FLIPI), and Eastern Cooperative Oncology Group (ECOG) performance status.
ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation.
Hedrick et al., San Diego, United States. In Immunity, Mar 2015
We report that ICOS signaling inactivates the transcription factor FOXO1, and a Foxo1 genetic deletion allowed for generation of Tfh cells with reduced dependence on ICOS ligand.
Rhabdomyosarcoma: Advances in Molecular and Cellular Biology.
Duan et al., Boston, United States. In Sarcoma, 2014
The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually genetically heterogeneous.
Somova et al., In Adv Gerontol, 2014
Associations between APOE, FOXO1A, FOXO3A, AKT1 gene polymorphisms and human longevity were confirmed in independent studies.
Insights into Transcriptional Regulation of Hepatic Glucose Production.
Jitrapakdee et al., Bangkok, Thailand. In Int Rev Cell Mol Biol, 2014
Glucoregulatory hormones can alter the rate of enzyme synthesis at the transcriptional step by modulating the key transcription factors and coactivators, such as CREB/CRTC2, FoxO1, nuclear receptors, C/EBPα, hepatocyte nuclear factors, PGC1α, and CLOCK genes.
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
Egwuagu et al., Bethesda, United States. In J Biol Chem, 2012
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
Involvement of the up-regulated FoxO1 expression in follicular granulosa cell apoptosis induced by oxidative stress.
Liu et al., Nanjing, China. In J Biol Chem, 2012
up-regulation of FoxO1 by oxidative stress leads to apoptosis of granulosa cells, which eventually results in follicular atresia in mice.
FOXO1 in the ventromedial hypothalamus regulates energy balance.
Elmquist et al., Dallas, United States. In J Clin Invest, 2012
the transcriptional networks modulated by FOXO1 in ventromedial hypothalamus neurons are key components in the regulation of energy balance and glucose homeostasis.
FoxO1 target Gpr17 activates AgRP neurons to regulate food intake.
Accili et al., New York City, United States. In Cell, 2012
Study finds that transcription factor FoxO1 exerts integrative control of leptin, insulin, and amino acid signaling in AgRP neurons, effectively coordinating food intake with peripheral metabolism; and identifies of a heretofore unrecognized FoxO1 pathway that regulates food intake through the G protein-coupled receptor, Gpr17.
Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation.
Myers et al., Boston, United States. In Plos Genet, 2012
These results implicate FOXO1 as a Parkinson disease-relevant gene and warrant further functional analyses of its transcriptional regulatory mechanisms.
More papers using FOXO1 antibodies
Multidimentional transfer functions for volume rendering
Frankel Wayne, In PLoS Genetics, 1997
... Pax3:Fkhr transgenic mice have been previously ...
Direct effects of leptin on brown and white adipose tissue
Calbet Jose A. L., In PLoS ONE, 1996
... cytokine signaling 3 (SOCS3) were from Cell Signaling Technology (Danvers, MA, USA), antibodies against Akt, F4/80, FOXO1 and IRβ were from Santa Cruz Biotechnology Inc ...
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