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Forkhead box R1

FOXN5, FOXR1, DLNB13, Fox RI
This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MLL, ACID, HTLF, Foxn1, Foxn4
Papers on FOXN5
Cancer genetics and genomics of human FOX family genes.
Review
Katoh et al., Tokyo, Japan. In Cancer Lett, 2013
In neuroblastoma, the entire coding region of the FOXR1 (FOXN5) gene is fused to the MLL or the PAFAH1B gene owing to interstitial deletions.
Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastoma.
GeneRIF
Molenaar et al., Amsterdam, Netherlands. In Oncogene, 2012
FOXR1 is recurrently activated in neuroblastoma by intrachromosomal deletion/fusion events, resulting in overexpression of fusion transcripts
Characterization of human FOXN4 gene in silico.
Katoh et al., Japan. In Int J Mol Med, 2004
FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1) and FOXN6 (FOXR2) genes constitute the FOXN gene family.
Human FOX gene family (Review).
Review
Katoh et al., Japan. In Int J Oncol, 2004
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD5 (FOXD4L1), FOXD6 (FOXD4L3), FOXE1, FOXE2, FOXE3, FOXF1, FOXF2, FOXG1 (FOXG1B), FOXH1, FOXI1, FOXJ1, FOXJ2, FOXJ3, FOXK1, FOXK2, FOXL1, FOXL2, FOXM1, FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1), FOXN6 (FOXR2), FOXO1 (FOXO1A), FOXO2 (FOXO6), FOXO3 (FOXO3A), FOXO4 (MLLT7), FOXP1, FOXP2, FOXP3, FOXP4, and FOXQ1.
Germ-line mutation of Foxn5 gene in mouse lineage.
GeneRIF
Katoh et al., Narashino, Japan. In Int J Mol Med, 2004
Foxn5 was identified and characterized as a germ-line mutation.
Identification and characterization of TMEM24 family genes in silico.
Katoh et al., Narashino, Japan. In Int J Oncol, 2004
MLL gene at human chromosome 11q23.3 is frequently rearranged or amplified in hematological malignancies, while PHLDB1, BCL9L, FOXN5 (FOXR1), RNF26, and MFRP genes linked to MLL gene are deleted in neuroblastoma.
Identification and characterization of human FOXK1 gene in silico.
Katoh et al., Narashino, Japan. In Int J Mol Med, 2004
At least 42 FOX family genes, including FOXK1, FOXN5 (FOXR1) and FOXN6 (FOXR2), have been identified within the human genome.
Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico.
Katoh et al., Narashino, Japan. In Int J Oncol, 2004
FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4 and FOXN5 (FOXR1) constitute the FOXN family.
Identification and characterization of human FOXN5 and rat Foxn5 genes in silico.
Katoh et al., Narashino, Japan. In Int J Oncol, 2004
Here, we identified and characterized the FOXN5 gene, a novel member of FOXN gene family, by using bioinformatics.
Identification and characterization of human LL5A gene and mouse Ll5a gene in silico.
Katoh et al., Narashino, Japan. In Int J Oncol, 2003
ARCN1, KIAA0638, TREH, DDX6, BLR1, BCL9L, UPK2, DLNB13, DLNB14, RPS25, SBDN, G6PT1, HYOU1, VPS11, HMBS, H2AFX, DPAGT1, KIAA0285, MIZF, ABCG4, NOD9, PDZK2, CBL, MCAM, RNF26, C1QTNF5, MFRP, USP2, THY1, and PVRL1 genes are located within the commonly deleted region of neuroblastoma at human chromosome 11q23.3.
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