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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Forkhead box N4

Foxn4
Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Foxn1, HTLF, FOXN5, CHES1, ACID
Papers on Foxn4
Conversion of the thymus into a bipotent lymphoid organ by replacement of FOXN1 with its paralog, FOXN4.
Boehm et al., Freiburg, Germany. In Cell Rep, 2014
A hypothetical primordial form of the thymus was established in mice by replacing FOXN1, the vertebrate-specific master regulator of thymic epithelial cell function, with its metazoan ancestor, FOXN4, thereby resetting the regulatory and coding changes that have occurred since the divergence of these two paralogs.
Autophagy is essential for cardiac morphogenesis during vertebrate development.
Amatruda et al., Dallas, United States. In Autophagy, 2014
Further analyses of cardiac development in autophagy-deficient zebrafish revealed defects in cardiac looping, abnormal chamber morphology, aberrant valve development, and ectopic expression of critical transcription factors including foxn4, tbx5, and tbx2.
Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors.
GeneRIF
Xiang et al., United States. In Proc Natl Acad Sci U S A, 2012
Foxn4 has an intrinsic activity to suppress the alternative photoreceptor cell fates of early retinal progenitors by selectively activating Dll4-Notch signaling.
A regulatory domain is required for Foxn4 activity during retinogenesis.
GeneRIF
Guillonneau et al., Paris, France. In J Mol Neurosci, 2012
Mouse Foxn4 transfection reduced by 2.7-fold the basal level of Tbx2 promoter transcription, but deletion of the AD domain increased transcription showing that this domain might be a transregulatory domain.
CD44+ cancer stem-like cells in EBV-associated nasopharyngeal carcinoma.
Lo et al., Hong Kong, Hong Kong. In Plos One, 2011
FOXN4, GLI1), immune response (CCR7, IL8) and transmembrane transport (e.g.
Foxn4 influences alveologenesis during lung development.
GeneRIF
Xiang et al., United States. In Dev Dyn, 2011
Foxn4 may have a non-cell-autonomous role critical for alveologenesis during lung development.
Foxn4 is required for retinal ganglion cell distal axon patterning.
GeneRIF
Goldberg et al., Miami, United States. In Mol Cell Neurosci, 2011
findings show that Foxn4 is required for proper outgrowth of retinal ganglion cell (RGC) axons in vivo, suggesting a role for an amacrine cell-RGC interaction in axon growth
Characterization of the human PANK2 promoter.
Hayflick et al., Portland, United States. In Gene, 2010
Moreover, we identify potential regulators of PANK2 expression, including NF-Y, FOXN4 and the human heterogeneous nuclear ribonucleoprotein A/B family.
Foxn4 directly regulates tbx2b expression and atrioventricular canal formation.
Stainier et al., San Francisco, United States. In Genes Dev, 2008
We show that the zebrafish gene slipjig, which encodes Foxn4, regulates the formation of the atrioventricular (AV) canal to divide the heart.
A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool.
GeneRIF
Richardson et al., London, United Kingdom. In Development, 2007
Foxn4 induces expression of delta-like 4 (Dll4) and Mash1 (Ascl1). Dll4 then signals through Notch1 to subdivide the p2 progenitor pool in the ventral spinal cord.
Characterization of human FOXN4 gene in silico.
Katoh et al., Japan. In Int J Mol Med, 2004
FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1) and FOXN6 (FOXR2) genes constitute the FOXN gene family.
Human FOX gene family (Review).
Review
Katoh et al., Japan. In Int J Oncol, 2004
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD5 (FOXD4L1), FOXD6 (FOXD4L3), FOXE1, FOXE2, FOXE3, FOXF1, FOXF2, FOXG1 (FOXG1B), FOXH1, FOXI1, FOXJ1, FOXJ2, FOXJ3, FOXK1, FOXK2, FOXL1, FOXL2, FOXM1, FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1), FOXN6 (FOXR2), FOXO1 (FOXO1A), FOXO2 (FOXO6), FOXO3 (FOXO3A), FOXO4 (MLLT7), FOXP1, FOXP2, FOXP3, FOXP4, and FOXQ1.
Expression of the winged helix/forkhead gene, foxn4, during zebrafish development.
GeneRIF
Steiner et al., Cambridge, United States. In Brain Res Dev Brain Res, 2004
adult thymus is the only major site of foxn4 expression outside of the nervous system
Identification and characterization of human FOXN6, mouse Foxn6, and rat Foxn6 genes in silico.
Katoh et al., Narashino, Japan. In Int J Oncol, 2004
FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4 and FOXN5 (FOXR1) constitute the FOXN family.
Identification and characterization of human FOXN5 and rat Foxn5 genes in silico.
Katoh et al., Narashino, Japan. In Int J Oncol, 2004
FOXN1, FOXN2 (HTLF), FOXN3 (CHES1) and FOXN4 constitute the FOXN family.
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