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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Forkhead box N1

Foxn1, Whn, Rowett nude
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAIR, Tec, HAD, CAN, cytokeratin
Papers on Foxn1
Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development.
New
Kyewski et al., Heidelberg, Germany. In J Immunol, Jan 2016
To this end, we used conditional knockout mice (FoxN1-Gpr177) in which TECs are unable to secrete Wnt ligands.
Thymic Epithelial Cells Induced from Pluripotent Stem Cells by a Three-Dimensional Spheroid Culture System Regenerates Functional T Cells in Nude Mice.
New
Isobe et al., Nagoya, Japan. In Cell Reprogram, Oct 2015
Purified iPSC-derived TECs showed a sufficient expression level of FoxN1 comparable to TECs, and phenotypic analysis revealed that iPSC-derived TECs were expressing K5.
3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression.
Kyewski et al., In J Vis Exp, 2014
The 3D model preserved key functional features of mTEC biology: (i) proliferation and terminal differentiation of CD80(lo), Aire-negative into CD80(hi), Aire-positive mTECs, (ii) responsiveness to RANKL, and (iii) sustained expression of FoxN1, Aire and tissue-restricted genes in CD80(hi) mTECs.
Decline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation.
Takacs et al., Rio de Janeiro, Brazil. In Immun Ageing, 2014
RESULTS: As an initial approach, here we report that the decline of human thymic FOXN1 transcription correlates with age, while other genes, DLL1, DLL4 and WNT4, essential for thymopoiesis, are constitutively transcribed.
Whole-Exome Sequencing in a South American Cohort Links ALDH1A3, FOXN1 and Retinoic Acid Regulation Pathways to Autism Spectrum Disorders.
Lattig et al., Bogotá, Colombia. In Plos One, 2014
Two missense novel SNVs were found in the same child: ALDH1A3 (RefSeq NM_000693: c.1514T>C (p.I505T)) and FOXN1 (RefSeq NM_003593: c.146C>T (p.S49L)).
An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts.
Impact
Blackburn et al., Edinburgh, United Kingdom. In Nat Cell Biol, 2014
The transcription factor forkhead box N1 (FOXN1) is critically required for development of thymic epithelial cells (TECs), a key cell type of the thymic stroma.
Adult thymus contains FoxN1(-) epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineages.
Impact
Kyewski et al., Heidelberg, Germany. In Immunity, 2014
The FoxN1 transcription factor was dispensable for TSFCs maintenance in situ and for commitment to the medullary and cortical TEC lineages.
FOXN1 in organ development and human diseases.
Review
Pignata et al., Napoli, Italy. In Int Rev Immunol, 2014
A mutation in FoxN1 generates alymphoid cystic thymic dysgenesis due to defective TECs, causing primary T-cell immunodeficiency, named Nude/SCID syndrome, and leads to a hairless "nude" phenotype in both mice and humans.
Animal models of skin regeneration.
Review
Kur et al., Olsztyn, Poland. In Reprod Biol, 2014
However, we especially focused on the attributes of two unusual models of skin scar-free healing capabilities that occur in adult mammals, that is, those associated with nude, FOXN1-deficient mice and in wild-type African spiny mice.
Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo.
Impact
Deng et al., Shenzhen, China. In Cell Stem Cell, 2013
The hESC-derived TEPLCs expressed the key thymic marker gene FOXN1 and could further develop in vivo into thymic epithelium expressing the functional thymic markers MHC II and AIRE upon transplantation.
[Post-thymus transplant vitiligo in a child with Foxn1 deficiency].
GeneRIF
Lipsker et al., Strasbourg, France. In Ann Dermatol Venereol, 2012
This is the first description of leucoderma occurring in a patient with Foxn1 deficiency, as well as the first report of this pigment abnormality following thymus transplantation.
Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging.
GeneRIF
Shams et al., Tyler, United States. In Plos One, 2011
Findings provide the first evidence that K14-mediated FoxN1 deletion causes changes in T-cell function that mimic those in aging during an immune response to challenge with an infectious agent.
Insights on FoxN1 biological significance and usages of the "nude" mouse in studies of T-lymphopoiesis.
Review
Su et al., Fort Worth, United States. In Int J Biol Sci, 2011
Mutation in the "nude" gene, i.e. the FoxN1 gene, induces a hairless phenotype and a rudimentary thymus gland in mice (nude mouse) and humans (T-cell related primary immunodeficiency).
From murine to human nude/SCID: the thymus, T-cell development and the missing link.
Review
Pignata et al., Napoli, Italy. In Clin Dev Immunol, 2011
With this regard, the prototype of athymic disorders due to abnormal stroma is the Nude/SCID syndrome, first described in mice in 1966.
Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells.
GeneRIF
Le et al., Maywood, United States. In Blood, 2011
Manipulation of Foxn1 expression in the thymus ameliorates thymopoiesis in aged mice and offer a strategy to combat the age-associated decline in naive T-cell production and CD4 naive/memory ratios in the elderly.
Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence.
GeneRIF
Blackburn et al., Edinburgh, United Kingdom. In Plos Genet, 2011
regulation by Foxn1 of a suite of genes with diverse roles in thymus development and/or function, suggests it acts as a master regulator of the core thymic epithelial programme.
FOXN1 mutation abrogates prenatal T-cell development in humans.
GeneRIF
Pignata et al., Napoli, Italy. In J Med Genet, 2011
results show that FOXN1 is crucial for in utero T cell development, but not for B and NK cell differentiation
A thymus candidate in lampreys.
Impact
Boehm et al., Freiburg, Germany. In Nature, 2011
Only in the thymoids was expression of the orthologue of the gene encoding forkhead box N1 (FOXN1), a marker of the thymopoietic microenvironment in jawed vertebrates, accompanied by expression of CDA1 and VLRA.
Human clinical phenotype associated with FOXN1 mutations.
Review
GeneRIF
Amorosi et al., Napoli, Italy. In Adv Exp Med Biol, 2008
role of FOXN1 in immunological disorders characterized by abnormal T-cell development or abnormal T-cell regulatory homeostasis [Review]
Forkhead-box transcription factors and their role in the immune system.
Review
Impact
Burgering et al., Utrecht, Netherlands. In Nat Rev Immunol, 2004
This review focuses on FOXP3, FOXN1, FOXJ1 and members of the FOXO subfamily and their function in the immune system.
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