Unraveling the Link Between Ectodermal Disorders and Primary Immunodeficiencies.
Napoli, Italy. In Int Rev Immunol, Apr 2015
Alterations in the transcription factor FOXN1 gene, expressed in the mature thymic and skin epithelia, are responsible for human and murine athymia and prevent the development of the T-cell compartment associated to ectodermal abnormalities such as alopecia and nail dystrophy.
Animal models of skin regeneration.
Olsztyn, Poland. In Reprod Biol, 2014
However, we especially focused on the attributes of two unusual models of skin scar-free healing capabilities that occur in adult mammals, that is, those associated with nude, FOXN1-deficient mice and in wild-type African spiny mice.
FOXN1 in organ development and human diseases.
Napoli, Italy. In Int Rev Immunol, 2014
A mutation in FoxN1 generates alymphoid cystic thymic dysgenesis due to defective TECs, causing primary T-cell immunodeficiency, named Nude/SCID syndrome, and leads to a hairless "nude" phenotype in both mice and humans.
A thymus candidate in lampreys.
Freiburg, Germany. In Nature, 2011
Only in the thymoids was expression of the orthologue of the gene encoding forkhead box N1 (FOXN1), a marker of the thymopoietic microenvironment in jawed vertebrates, accompanied by expression of CDA1 and VLRA.