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Forkhead box L2

FOXL2, Pinto, BPES
This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jun 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, DMRT1, AGE
Papers using FOXL2 antibodies
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
Supplier
Ottolenghi Chris et al., In BMC Developmental Biology, 2005
... Foxl2 transgenic mouse embryonic gonads ...
Papers on FOXL2
Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT) Commonly Exhibits Positivity With Sex Cord Markers FOXL2 and SF-1 but Lacks FOXL2 and DICER1 Mutations.
New
McCluggage et al., Belfast, United Kingdom. In Int J Gynecol Pathol, Dec 2015
To further explore the sex cord lineage of UTROSCT, we studied 19 of these neoplasms and examined the expression of 2 recently described markers of ovarian sex cord-stromal tumors, FOXL2, and steroidogenic factor-1.
Comprehensive transcriptomic analysis of the process of gonadal sex differentiation in the turbot (Scophthalmus maximus).
New
Piferrer et al., Barcelona, Spain. In Mol Cell Endocrinol, Dec 2015
Although no genes mapped to the previously identified sex-related QTLs, two genes (foxl2 and 17βhsd) of the canonical reproduction-related genes mapped to growth-QTLs in linkage group (LG) 15 and LG6, respectively, suggesting that these genes are related to the growth dimorphism in this species.
Ovarian development and disease: The known and the unexpected.
Review
New
Chaboissier et al., Fribourg, Switzerland. In Semin Cell Dev Biol, Sep 2015
The role and interactions of WNT4, RSPO1 and other factors, such as FOXL2 as well as the possible role of chromatin modifiers such as the polycomb protein CBX2 in ovarian development and function will be discussed.
Minireview: Activin Signaling in Gonadotropes: What Does the FOX say… to the SMAD?
Review
New
Bernard et al., Toronto, Canada. In Mol Endocrinol, Jul 2015
The activin signaling molecules SMAD3 and SMAD4 appear to partner with the winged-helix/forkhead transcription factor, forkhead box L2 (FOXL2), to regulate expression of all 3 genes.
Maternal organism and embryo biosensoring: insights from ruminants.
Review
New
Charpigny et al., Jouy-le-Moutier, France. In J Reprod Immunol, Apr 2015
FOXL2, SOCS6).
Sexual Fate Reprogramming in the Steroid-Induced Bi-Directional Sex Change in the Protogynous Orange-Spotted Grouper, Epinephelus coioides.
Chang et al., Chi-lung, Taiwan. In Plos One, 2014
These male characteristics included increased plasma 11-ketotestosterone (11-KT), decreased estradiol (E2) levels, increased male-related gene (dmrt1, sox9, and cyp11b2) expression, and decreased female-related gene (figla, foxl2, and cyp19a1a) expression.
An integrative taxonomic approach to characterize Trichogramma marandobai (Hymenoptera: Trichogrammatidae).
Zucchi et al., Piracicaba, Brazil. In Zootaxa, 2014
Trichogramma is the largest genus of Trichogrammatidae, with nearly 210 species worldwide (Pinto 2006), of which 41 species occur in South America and 26 in Brazil (Zucchi et al. 2010).
Biological, morphological and morphometric studies of Triatoma melanocephala Neiva & Pinto, 1923 (Hemiptera: Reduviidae: Triatominae).
Rosa et al., Jaú, Brazil. In Zootaxa, 2014
Triatoma melanocephala Neiva & Pinto is found in the Brazilian states of Bahia, Paraíba, Pernambuco, Rio Grande do Norte, and Sergipe.
Adult granulosa cell tumours of the ovary.
Review
Colombo et al., Roma, Italy. In Curr Opin Oncol, 2014
RECENT FINDINGS: Novel biomarkers, including FOXL2, SMAD3 and GATA4, have been identified as potential diagnostic and therapeutic targets for this type of tumour.
Characterising novel pathways in testis determination using mouse genetics.
Review
Greenfield et al., United Kingdom. In Sex Dev, 2013
Studies in 2 broad areas have been especially revealing: (i) identification of pathways required for the appropriate expression of Sry, and (ii) characterisation of the antagonistic interactions between the core testis- (SRY-SOX9-FGF9) and ovary- (RSPO1-WNT4-CTNNB1-FOXL2) determining gene regulatory networks.
FOXL2 mutations in granulosa cell tumors occurring in males.
GeneRIF
Medeiros et al., Rochester, United States. In Arch Pathol Lab Med, 2012
The FOXL2 402C-->G (C134W) mutation is also present in adult-type granulosa cell tumors occurring in men, although in a smaller proportion when compared with women. FOXL2 can be a helpful in the diagnosis of granulosa cell tumors of the testis.
FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoter.
GeneRIF
Thackray et al., San Diego, United States. In Endocrinology, 2012
Protein-protein interactions among FOXL2, SMAD3, and progesterone receptor (PR) recruited to the Fshb promoter play a key role in facilitating Fshb transcription before the secondary FSH surge in rodents.
The C134W (402 C>G) FOXL2 mutation is absent in ovarian gynandroblastoma: insights into the genesis of an unusual tumour.
GeneRIF
Herrington et al., Dundee, United Kingdom. In Histopathology, 2012
The C134W (402 C>G) FOXL2 mutation is absent in ovarian gynandroblastoma.
Molecular pathogenesis of granulosa cell tumors of the ovary.
Review
Impact
Fuller et al., Australia. In Endocr Rev, 2012
Most recently, the finding that approximately 97% of adult GCT harbor a somatic missense mutation in the FOXL2 gene (c.402C→G;
Missense mutation outside the forkhead domain of FOXL2 causes a severe form of BPES type II.
GeneRIF
De Baere et al., Oxford, United Kingdom. In Mol Vis, 2011
A heterozygous FOXL2 missense mutation c.650C-->G (p.Ser217Cys) co-segregating with disease in members of a three-generation Iranian family with BPES type II is described.
[Mutation analysis of FOXL2 gene in Chinese patients with blepharophimosis-ptosis-epicanthus inversus syndrome].
GeneRIF
Zhang et al., Hangzhou, China. In Zhonghua Yan Ke Za Zhi, 2011
Two novel heterozygous mutations in FOXL2 were detected from Chinese blepharophimosis-ptosis-epicanthus inversus syndrome patients.
DMRT1 prevents female reprogramming in the postnatal mammalian testis.
Impact
Zarkower et al., Minneapolis, United States. In Nature, 2011
In females the primary sex-determining decision is not final: loss of the FOXL2 transcription factor in adult granulosa cells can reprogram granulosa cells into Sertoli cells.
A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population.
Impact
Zembutsu et al., Tokyo, Japan. In Nat Genet, 2010
Associations on chromosome 3 were observed at two separate linkage disequilibrium (LD) blocks: rs1511412 in the LD block including FOXL2 with P = 2.31 x 10(-13) (OR = 1.87) and rs940187 in another LD block with P = 1.80 x 10(-13) (OR = 1.98).
Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation.
Impact
GeneRIF
Treier et al., Heidelberg, Germany. In Cell, 2010
Study demonstrates in the mouse that a single factor, the forkhead transcriptional regulator FOXL2, is required to prevent transdifferentiation of an adult ovary to a testis.
Mutation of FOXL2 in granulosa-cell tumors of the ovary.
Impact
GeneRIF
Huntsman et al., Vancouver, Canada. In N Engl J Med, 2009
identified a single, recurrent somatic mutation (402C-->G) in FOXL2 that was present in almost all morphologically identified adult-type GCTs. Mutant FOXL2 is a potential driver in the pathogenesis of adult-type GCTs
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