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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Forkhead box L1

FOXL1, fkh-6
Top mentioned proteins: FOXC2, Shh, Foxf1, Gli, Ihh
Papers on FOXL1
Genomic structure and promoter functional analysis of GnRH3 gene in large yellow croaker (Larimichthys crocea).
Wu et al., Zhoushan, China. In Gene, Feb 2016
Analysis of the 2576bp promoter fragment of LcGnRH3 showed a number of transcription factor binding sites, such as AP1, CREB, GATA-1, HSF, FOXA2, and FOXL1.
Inhibitory effects of forkhead box L1 gene on osteosarcoma growth through the induction of cell cycle arrest and apoptosis.
Wu et al., Bengbu, China. In Oncol Rep, Jul 2015
Forkhead box L1 (FOXL1), which is considered a novel candidate tumor suppressor, inhibits proliferation and invasion in certain types of cancer.
Identifying novel biomarkers of gastric cancer through integration analysis of single nucleotide polymorphisms and gene expression profile.
Hou et al., Beijing, China. In Int J Biol Markers, Jul 2015
In the regulatory network, transcription factor forkhead box L1 (FOXL1) regulated 26 DEGs with risk associated SNP loci, including Iroquois homeobox 1 (IRX1) rs11134044, sex determining region Y (SRY)-box1 (SOX1) rs9549447 and msh homeobox 1 (MSX1) rs41451149.
Integrative genomic analyses of a novel cytokine, interleukin-34 and its potential role in cancer prediction.
Xia et al., Guangzhou, China. In Int J Mol Med, 2015
The upstream transcription factor 1 (USF1), regulatory factor X-1 (RFX1), the Sp1 transcription factor 1 , POU class 3 homeobox 2 (POU3F2) and forkhead box L1 (FOXL1) regulatory transcription factor binding sites were identified in the IL-34 gene upstream (promoter) region, which may be involved in the effects of IL-34 in tumors.
Adaptation of peroxisome proliferator-activated receptor alpha to hibernation in bats.
Pan et al., Shanghai, China. In Bmc Evol Biol, 2014
Transcription factors such as FOXL1, NFYA, NFYB, SP1, TBP, and ERG were bioinformatically determined to have a higher binding affinity to the potential regulatory regions of Pparα in hibernating than in non-hibernating mammals.
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
Houlston et al., Riyadh, Saudi Arabia. In Sci Rep, 2014
The combined analysis identified new, significant associations with CRC at 1p36.2 marked by rs72647484 (minor allele frequency [MAF] = 0.09) near CDC42 and WNT4 (P = 1.21 × 10(-8), odds ratio [OR] = 1.21 ) and at 16q24.1 marked by rs16941835 (MAF = 0.21, P = 5.06 × 10(-8); OR = 1.15) within the long non-coding RNA (lncRNA) RP11-58A18.1 and ~500 kb from the nearest coding gene FOXL1.
MicroRNA-99a and 100 mediated upregulation of FOXA1 in bladder cancer.
Catto et al., Sheffield, United Kingdom. In Oncotarget, 2014
We confirm direct targeting of the FOXA1 3'UTR by microRNAs-99a/100 and also potential indirect regulation through microRNA-485-5p/SOX5/JUN-D/FOXL1 and microRNA-486/FOXO1a.
Forkhead box L1 is frequently downregulated in gallbladder cancer and inhibits cell growth through apoptosis induction by mitochondrial dysfunction.
Quan et al., Shanghai, China. In Plos One, 2013
BACKGROUND: Forkhead box L1 (FOXL1), considered as a novel candidate tumor suppressor, suppresses proliferation and invasion in certain cancers.
Association of osteoporosis susceptibility genes with bone mineral density and bone metabolism related markers in Koreans: the Chungju Metabolic Disease Cohort (CMC) study.
Kang et al., Seoul, South Korea. In Endocr J, 2013
The following 10 SNPs were genotyped: ZBTB40 rs6426749, MEF2C rs1366594, ESR1 rs2941740, TNFRSF11B rs3134070, TNFRSF11B rs2073617, SOX6 rs711785, LRP5 rs599083, TNFSF11 rs227438, TNFSF11 rs9594782, and FOXL1 rs10048146; and the association between these SNPs and bone metabolism-related markers was assessed.
Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed.
Kiel et al., Boston, United States. In J Clin Endocrinol Metab, 2012
Among 59 novel BMD GWAS loci that have not been reported by previous candidate gene association studies, some have been shown to be involved in key biological pathways involving the skeleton, particularly Wnt signaling (AXIN1, LRP5, CTNNB1, DKK1, FOXC2, HOXC6, LRP4, MEF2C, PTHLH, RSPO3, SFRP4, TGFBR3, WLS, WNT3, WNT4, WNT5B, WNT16), bone development: ossification (CLCN7, CSF1, MEF2C, MEPE, PKDCC, PTHLH, RUNX2, SOX6, SOX9, SPP1, SP7), mesenchymal-stem-cell differentiation (FAM3C, MEF2C, RUNX2, SOX4, SOX9, SP7), osteoclast differentiation (JAG1, RUNX2), and TGF-signaling (FOXL1, SPTBN1, TGFBR3).
FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1.
Mertens et al., Lund, Sweden. In Clin Cancer Res, 2011
FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1.
Genetic factors in esophageal atresia, tracheo-esophageal fistula and the VACTERL association: roles for FOXF1 and the 16q24.1 FOX transcription factor gene cluster, and review of the literature.
Shaw-Smith, Cambridge, United Kingdom. In Eur J Med Genet, 2010
Recently, microdeletions of the FOX gene cluster at 16q24.1, comprising four genes, FOXF1, MTHFSD, FOXC2 and FOXL1, were reported to cause a phenotype resembling VACTERL association, with vertebral anomalies, gastro-intestinal atresias (esophageal, duodenal and anal), congenital heart malformations, and urinary tract malformations, as well as a rare lethal developmental anomaly of the lung, alveolar capillary dysplasia.
Foxl1 promotes liver repair following cholestatic injury in mice.
Greenbaum et al., Philadelphia, United States. In Lab Invest, 2009
promotes liver repair after bile-duct-ligation-induced liver injury through activation of the canonical wnt/beta-catenin pathway
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
Genetic Factors for Osteoporosis (GEFOS) Consortium et al., Rotterdam, Netherlands. In Nat Genet, 2009
(LRP4, ARHGAP1, F2), 11p14.1 (DCDC5), 11p15 (SOX6), 16q24 (FOXL1), 17q21 (HDAC5) and 17q12 (CRHR1).
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Katoh et al., Japan. In Curr Mol Med, 2009
GLI activators bind to GACCACCCA motif to regulate transcription of GLI1, PTCH1, PTCH2, HHIP1, MYCN, CCND1, CCND2, BCL2, CFLAR, FOXF1, FOXL1, PRDM1 (BLIMP1), JAG2, GREM1, and Follistatin.
Foxl1 is a marker of bipotential hepatic progenitor cells in mice.
Greenbaum et al., Philadelphia, United States. In Hepatology, 2009
Foxl1 is a bona fide marker of the facultative progenitor cell in the mouse liver.
Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review).
Katoh et al., Japan. In Int J Mol Med, 2008
GLI activators then upregulate CCND1, CCND2 for cell cycle acceleration, FOXA2, FOXC2, FOXE1, FOXF1, FOXL1, FOXP3, POU3F1, RUNX2, SOX13, TBX2 for cell fate determination, JAG2, INHBC, and INHBE for stem cell signaling regulation.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
Hedgehog signals induce upregulation of SFRP1, JAG2 and FOXL1, and then FOXL1 induces BMP4 upregulation.
Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon.
Kaestner et al., Philadelphia, United States. In Genes Dev, 2005
Mesenchymal Modifier of Min, plays a key role in gastrointestinal tumorigenesis.
Foxl1 null mice have abnormal intestinal epithelia, postnatal growth retardation, and defective intestinal glucose uptake.
Kaestner et al., Philadelphia, United States. In Am J Physiol Gastrointest Liver Physiol, 2004
link between a mesenchymal factor, Foxl1, and the regulation of a specific epithelial transport process in intestinal epithelium
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