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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Forkhead box D3

FoxD3, AISI, AIS1
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008] (from NCBI)
Top mentioned proteins: CAN, Sox2, Nanog, Slug, TUBE
Papers on FoxD3
In silico, in vitro and in vivo analysis identifies a potential role for steroid hormone regulation of FOXD3 in endometriosis-associated genes.
New
Hapangama et al., Liverpool, United Kingdom. In Hum Reprod, Feb 2016
SUMMARY ANSWER: Systems integration and analysis of existing complex (published) datasets, predicted a role for the novel transcription factor, Forkhead Box D3 (FOXD3) in healthy endometrium and in endometriosis, which was followed by the demonstration of decreased levels of the protein upon decidualisation of normal human endometrial stromal cells in vitro and differential endometrial expression in the stroma in endometriosis.
FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.
New
Impact
Blelloch et al., San Francisco, United States. In Cell Stem Cell, Feb 2016
Here, we evaluated regulation of enhancer activity during differentiation of embryonic stem to epiblast cells and uncovered the forkhead transcription factor FOXD3 as a major regulator of the developmental potential of both pluripotent states.
Growth-Arrest-Specific 7 Gene Regulates Neural Crest Formation and Craniofacial Development in Zebrafish.
New
Chao et al., Anyang, China. In Stem Cells Dev, Jan 2016
In addition, NC cell sublineages that migrate to form neurons, glial cells, and melanocytes were altered in Gas7 morphants as revealed by aberrant expression of neurod, foxd3, and mitfa, respectively.
Characterisation of human gingival neural crest-derived stem cells in monolayer and neurosphere cultures.
New
Häkkinen et al., Vancouver, Canada. In Eur Cell Mater, Dec 2015
Human GFs and GSCs expressed NC-related genes nestin, Snai1, Twist1, Pax3, Sox9 and FoxD3, and generated neurospheres.
FOXD3 suppresses tumor growth and angiogenesis in non-small cell lung cancer.
New
Zhou et al., Shanghai, China. In Biochem Biophys Res Commun, Nov 2015
The transcription factor forkhead box D3 (FOXD3), widely studied as a transcriptional repressor in embryogenesis, participates in the carcinogenesis of many cancers.
A novel FoxD3 Variant Is Associated With Vitiligo and Elevated Thyroid Auto-Antibodies.
New
Körner et al., Leipzig, Germany. In J Clin Endocrinol Metab, Oct 2015
One candidate region is the autoimmunity susceptibility locus on chromosome 1, which encompasses forkhead transcription factor D3 (FoxD3), a gene involved in embryonal melanogenesis.
Axud1 Integrates Wnt Signaling and Transcriptional Inputs to Drive Neural Crest Formation.
New
Bronner et al., Pasadena, United States. In Dev Cell, Oct 2015
Furthermore, it physically interacts with neural plate border genes Pax7 and Msx1 in vivo to directly activate transcription of stem cell factor FoxD3, initiating the neural crest program.
A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
New
Leist et al., Dortmund, Germany. In Arch Toxicol, Sep 2015
Finally, optimization of the classifier based on 100 probe sets showed that eight genes (F2RL2, TFAP2B, EDNRA, FOXD3, SIX3, MT1E, ETS1 and LHX2) are sufficient to separate HDACi from mercurials.
Graphene Nanoplatelets Based Protective and Functionalizing Coating for Stainless Steel.
New
Sammelselg et al., In J Nanosci Nanotechnol, Sep 2015
Here we report a promising application of graphene oxide and graphene nanoplatelets as effective corrosion inhibitors for AISI type 304 stainless steel alloy.
Reviewing and updating the major molecular markers for stem cells.
Review
Bonatto et al., Porto Alegre, Brazil. In Stem Cells Dev, 2013
The commonly cited markers for embryonic ESCs are Nanog, Oct-4, Sox-2, Rex-1, Dnmt3b, Lin-28, Tdgf1, FoxD3, Tert, Utf-1, Gal, Cx43, Gdf3, Gtcm1, Terf1, Terf2, Lefty A, and Lefty B. MSCs are primarily identified by the expression of CD13, CD29, CD44, CD49e, CD54, CD71, CD73, CD90, CD105, CD106, CD166, and HLA-ABC and lack CD14, CD31, CD34, CD45, CD62E, CD62L, CD62P, and HLA-DR expression.
Current perspectives of the signaling pathways directing neural crest induction.
Review
García-Castro et al., New Haven, United States. In Cell Mol Life Sci, 2012
In the second phase, BMP, Wnt, and Notch signaling maintain these progenitors and bring about the expression of definitive NC markers including Snail2, FoxD3, and Sox9/10.
Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors.
GeneRIF
Labosky et al., Nashville, United States. In Dev Biol, 2012
The findings highlighted the crucial roles played by Foxd3 during enteric nervous system development including progenitor proliferation, neural patterning, and glial differentiation.
Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population.
GeneRIF
Knapik et al., Nashville, United States. In Dev Biol, 2012
tfap2a and foxd3 are expressed during gastrulation prior to neural crest induction in distinct, complementary, domains; tfap2a is expressed in the ventral non-neural ectoderm and foxd3 in the dorsal mesendoderm and ectoderm
Loss of Foxd3 results in decreased β-cell proliferation and glucose intolerance during pregnancy.
GeneRIF
Labosky et al., Nashville, United States. In Endocrinology, 2011
Foxd3 is upstream of several pathways critical for beta-cell mass expansion in vivo.
Analysis of FOXD3 sequence variation in human ocular disease.
GeneRIF
Semina et al., Milwaukee, United States. In Mol Vis, 2011
Six nonsynonymous FOXD3 variants were identified in human ocular disease.
Regulation of melanocyte pivotal transcription factor MITF by some other transcription factors.
Review
He et al., Kunming, China. In Mol Cell Biochem, 2011
Both immunoglobulin transcription factor-2 (ITF2) and forkhead-box transcription factor D3 (FOXD3) can negatively regulate MITF expression.
Generation of melanocytes from neural crest cells.
Review
Sommer, Zürich, Switzerland. In Pigment Cell Melanoma Res, 2011
Several transcription factors, such as FoxD3, Sox10, Pax3, and Mitf, take part in a genetic network regulating melanocyte formation from the neural crest.
FOXD3 regulates migration properties and Rnd3 expression in melanoma cells.
GeneRIF
Aplin et al., Philadelphia, United States. In Mol Cancer Res, 2011
FOXD3 regulates migration properties and Rnd3 expression in melanoma cells
The making of a melanocyte: the specification of melanoblasts from the neural crest.
Review
Erickson et al., Davis, United States. In Pigment Cell Melanoma Res, 2008
The transcriptional repressor FoxD3 occupies a central role in melanocyte fate determination by repressing melanogenesis in premigratory NC cells and in other NC lineages.
Update on late relapse of germ cell tumor: a clinical and molecular analysis.
Impact
Einhorn et al., Indianapolis, United States. In J Clin Oncol, 2003
Available specimens were investigated for expression of the transcription regulator FoxD3 and apurinic/apyrimidinic endonuclease and the presence of chromosome 12 abnormalities.
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