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Forkhead box C2

FOXC2, Mfh1
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, V1a, CAN, PCL, SNAIL
Papers on FOXC2
The relationship between EMT, CD44(high) /EGFR(low) phenotype, and treatment response in head and neck cancer cell lines.
Roberg et al., Linköping, Sweden. In J Oral Pathol Med, Feb 2016
METHODS: mRNA expression of the EMT-associated genes CDH1 (E-cadherin), CDH2 (N-cadherin), FOXC2, TWIST1, VIM (vimentin), and FN1 (fibronectin) was determined using quantitative real-time PCR.
FOXC2 is up-regulated in pancreatic ductal adenocarcinoma and promotes the growth and migration of cancer cells.
Chen et al., Zhenjiang, China. In Tumour Biol, Feb 2016
UNASSIGNED: The transcriptional factor Forkhead box protein C2 (FOXC2) was recently demonstrated to be up-regulated in various cancer types.
Prognostic value of high FoxC2 expression in resectable non-small cell lung cancer, alone or in combination with E-cadherin expression.
Pang et al., Shanghai, China. In Bmc Cancer, Dec 2015
BACKGROUND: FoxC2 is an epithelial-mesenchymal transition (EMT) regulator which induces metastasis.
Lymphatic Markers in the Adult Human Choroid.
Reitsamer et al., Salzburg, Austria. In Invest Ophthalmol Vis Sci, Dec 2015
Sections were processed for immunohistochemistry of the lymphatic markers LYVE-1, PDPN, PROX1, FOXC2, VEGFR3, CCL21, and combined with α-smooth muscle-actin and 4',6-diamidino-2-phenylendole (DAPI).
Towards an understanding of kidney diseases associated with WT1 mutations.
Englert et al., Jena, Germany. In Kidney Int, Oct 2015
WT1 controls metanephric mesenchyme (MM) self-renewal and proliferation mainly by regulating FGF and BMP-pSMAD signaling pathways as well as Sall1 and Pax2, encoding key transcription factors; WT1 drives MM differentiation and mesenchyme-epithelial transition by targeting Fgf8 and Wnt4; WT1 defines podocyte identity by activation of other podocyte-specific transcription factors, including Mafb, Lmx1b, FoxC2, and Tcf21.
Protein kinase CK2 in breast cancer: the CK2β regulatory subunit takes center stage in epithelial plasticity.
Cochet et al., Grenoble, France. In Cell Mol Life Sci, Sep 2015
Importantly, decreased CK2β expression in breast tumors is correlated with inefficient phosphorylation and nuclear translocation of Snail1 and Foxc2, ultimately leading to EMT induction.
Why increased nuchal translucency is associated with congenital heart disease: a systematic review on genetic mechanisms.
Haak et al., Amsterdam, Netherlands. In Prenat Diagn, Jun 2015
Fifteen candidate genes involved in both cardiac and lymphatic development were identified: Adrenomedullin; Chicken ovalbumin upstream promoter-transcription factor 2 (COUP-TFII); Cyp51; Ephrin-B2; Forkhead box protein C2 (Foxc2); Nuclear factor of activated T cells, cytoplasmic 1 (Nfatc1); Neurofibromatosis type 1 (Nf1); Phosphoinositide 3-kinase encoding isoform p110α (Pik3ca); Podoplanin; Prospero-related homeobox 1 (Prox1); T-box 1 (Tbx1); Tyrosine kinase with immunoglobulin-like and endothelial growth factor-like domains 1 (Tie1); vascular endothelial growth factor (Vegf)-A; Vegf receptor-3 (Vegfr-3); and Vascular endothelial zinc finger 1 (Vezf1).
Expression of FOXC2 in renal cell carcinoma and its relationship to clinical pathological features.
Kong et al., Zhengzhou, China. In Int J Clin Exp Med, 2014
OBJECTIVE: This study aimed to investigate expression level of FOXC2 and its relationship to clinical pathological features of renal cell carcinoma (RCC).
Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst.
Ikegawa et al., Tokyo, Japan. In Plos One, 2014
We previously showed that familial SEDAC is caused by FOXC2 mutation; however, the causal gene of sporadic SEDAC has not been identified.
Genetic polymorphisms of vein wall remodeling in chronic venous disease: a narrative and systematic review.
Lazo-Langner et al., London, Canada. In Blood, 2014
Important candidate genes/proteins include the matrix metalloproteinases (extracellular matrix degradation), vascular endothelial growth factors (angiogenesis and vessel wall integrity), FOXC2 (vascular development), hemochromatosis (involved in venous ulceration and iron absorption), and various types of collagen (contributors to vein wall strength).
Interplay of mechanotransduction, FOXC2, connexins, and calcineurin signaling in lymphatic valve formation.
Petrova et al., China. In Adv Anat Embryol Cell Biol, 2013
In this chapter, we will discuss the main steps of lymphatic valve morphogenesis, the important role of mechanotransduction in this process, and the genetic program regulated by the transcription factor Foxc2, which is indispensable for all steps of valve development.
Prognostic role of Twist, Slug, and Foxc2 expression in stage I non-small-cell lung cancer after curative resection.
Xi et al., Shanghai, China. In Clin Lung Cancer, 2012
Increased expression of Foxc2 was observed in 27.7% of primary NSCLC tumors. Overexpression of Foxc2 in stage I NSCLC was associated with a worse overall survival and correlated with a shorter recurrence-free survival.
Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2.
Iñiguez-Lluhí et al., Ann Arbor, United States. In J Biol Chem, 2012
findings demonstrate that SC motifs mediate the inhibitory function of this region by serving as sites for SUMOylation and reveal a novel mechanism for acute and reversible regulation of FOXC1/C2 function
Novel mutation in the FOXC2 gene in three generations of a family with lymphoedema-distichiasis syndrome.
Szuba et al., Wrocław, Poland. In Gene, 2012
describe three generations of a family with lymphedema-distichiasis syndrome. The mutation is a frameshift due to a deletion of two nucleotides in C repeats between C586 and C591, leading to protein truncation from an earlier insertion of a stop codon.
Nuclear localization of GLI1 and elevated expression of FOXC2 in breast cancer is associated with the basal-like phenotype.
Zhou et al., Shanghai, China. In Histol Histopathol, 2012
Nuclear localization of GLI1 and elevated expression of FOXC2 in breast cancer is associated with the basal-like phenotype.
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.
Alitalo et al., Helsinki, Finland. In Nat Cell Biol, 2011
FoxC2 is a known regulator of Notch ligand and target gene expression, and Foxc2(+/-);Vegfr3(+/-) compound heterozygosity recapitulated homozygous loss of Vegfr3.
Gene expression of mesenchyme forkhead 1 (FOXC2) significantly correlates with the degree of lymph node metastasis in colorectal cancer.
Nagawa et al., Tokyo, Japan. In Int Surg, 2011
FOXC2 expression was significantly correlatd with the degree of lymph node metastasis in colorectal cancer.
Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors.
Black et al., San Francisco, United States. In Cell, 2009
We demonstrate that coexpression of the Forkhead protein FoxC2 and the Ets protein Etv2 induces ectopic expression of vascular genes in Xenopus embryos, and that combinatorial knockdown of the orthologous genes in zebrafish embryos disrupts vascular development.
Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis.
Alitalo et al., Helsinki, Finland. In Nat Med, 2004
In lymphedema-distichiasis (LD), lymphatic vessel function fails because of mutations affecting the forkhead transcription factor FOXC2.
FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance.
Enerbäck et al., Göteborg, Sweden. In Cell, 2001
We have identified the human winged helix/forkhead transcription factor gene FOXC2 as a key regulator of adipocyte metabolism.
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