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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Forkhead box A3

Foxa3, HNF-3gamma, HNF3G
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HNF-3, Hepatocyte Nuclear Factor 3-beta, CAN, TCF, ACID
Papers on Foxa3
Transcription Factors and Medium Suitable for Initiating the Differentiation of Human Induced Pluripotent Stem Cells to the Hepatocyte Lineage.
Ishige et al., Yotsukaidō, Japan. In J Cell Biochem, Feb 2016
CCAAT/enhancer binding protein alpha (CEBPA), CCAAT/enhancer binding protein beta (CEBPB), forkhead box A1 (FOXA1), and forkhead box A3 (FOXA3) up-regulated AFP and down-regulated Nanog.
Alpha-cell dysfunctions and molecular alterations in male insulinopenic diabetic mice are not completely corrected by insulin.
Gosmain et al., Genève, Switzerland. In Endocrinology, Jan 2016
We identified genes coding for proteins involved in glucagon biosynthesis and secretion, α-cell differentiation and potential stress markers such as the glucagon, Arx, MafB, cMaf, Brain4, Foxa1, Foxa3, HNF4α, TCF7L2, Glut1, Sglt2, Cav2.1, Cav2.2, Nav1.7,
Calorie hoarding and thrifting: Foxa3 finds a way.
Mueller et al., Bethesda, United States. In Adipocyte, Oct 2015
Here we discuss how Forkhead box A3 (Foxa3), a family member of the forkhead box binding proteins, can potentially contribute to pathology by playing a double role in metabolism.
Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells.
Gosens et al., Groningen, Netherlands. In Thorax, Jul 2015
IL-13 decreased forkhead box protein A2 (FoxA2) expression (1.6-fold) and increased FoxA3 (3.6-fold) and SAM-pointed domain-containing ETS transcription factor (SPDEF) (5.2-fold) expression.
Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts.
Han et al., Seoul, South Korea. In Sci Rep, 2014
To elicit this direct conversion, we took advantage of an oriP/EBNA1-based episomal system to deliver a set of transcription factors, Gata4, Hnf1a, and Foxa3, to the fibroblasts.
Direct reprogramming of human fibroblasts to functional and expandable hepatocytes.
Hui et al., Shanghai, China. In Cell Stem Cell, 2014
Here, we generated human induced hepatocytes (hiHeps) from fibroblasts by lentiviral expression of FOXA3, HNF1A, and HNF4A.
Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors.
Hu et al., Shanghai, China. In Cell Stem Cell, 2013
We previously reported generation of induced hepatocyte-like (iHep) cells by transduction of Gata4, Hnf1α, and Foxa3 in p19 Arf null mouse embryonic fibroblasts (MEFs).
Reactive oxygen species signaling facilitates FOXO-3a/FBXO-dependent vascular BK channel β1 subunit degradation in diabetic mice.
Lee et al., Rochester, United States. In Diabetes, 2012
these results suggested that oxidative stress inhibited Akt signaling and facilitated the FOXO-3a/FBXO-dependent BK-beta(1) degradation in diabetic vessels.
FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program.
Lassar et al., Boston, United States. In Dev Cell, 2012
FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program
[Caloric restriction suppresses endothelial cells senescence via down-regulation of NOX4 induced by HNF3γ].
Wang et al., Hangzhou, China. In Yi Chuan, 2012
low caloric intake decreases the production of intracellular reactive oxygen species and suppresses endothelial cells senescence through promoting HNF3gamma binging to NOX4 promoter region and inhibiting NOX4 gene expression induced by up-regulated HNF3gamma
Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors.
Suzuki et al., Fukuoka, Japan. In Nature, 2011
Here, by screening the effects of twelve candidate factors, we identify three specific combinations of two transcription factors, comprising Hnf4α plus Foxa1, Foxa2 or Foxa3, that can convert mouse embryonic and adult fibroblasts into cells that closely resemble hepatocytes in vitro.
Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors.
Hui et al., Shanghai, China. In Nature, 2011
Here we demonstrate the direct induction of functional hepatocyte-like (iHep) cells from mouse tail-tip fibroblasts by transduction of Gata4, Hnf1α and Foxa3, and inactivation of p19(Arf).
FoxA transcription factors are essential for the development of dorsal axial structures.
Thisse et al., Charlottesville, United States. In Dev Biol, 2011
in FoxA2-FoxA3 double morphants, precursors of axial tissues are correctly induced at early gastrula stage, but their dorsal midline identity is not maintained during development
Testosterone induces redistribution of forkhead box-3a and down-regulation of growth and differentiation factor 9 messenger ribonucleic acid expression at early stage of mouse folliculogenesis.
Liu et al., Beijing, China. In Endocrinology, 2010
Intraovarian excess androgen in polycystic ovary syndrome may result in excess follicles by inducind Foxo 3a translocation.
The transcriptional regulation of the human CYP2C genes.
Goldstein et al., United States. In Curr Drug Metab, 2009
Other nuclear receptors and transcriptional factors including HNF4alpha, HNF3gamma, C/EBPalpha and more recently RORs, have been reported to regulate the constitutive expression of CYP2C genes in liver.
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
Dillin et al., Los Angeles, United States. In Nature, 2007
In the nematode worm Caenorhabditis elegans, the transcription factor PHA-4 has an essential role in the embryonic development of the foregut and is orthologous to genes encoding the mammalian family of Foxa transcription factors, Foxa1, Foxa2 and Foxa3.
Transcriptional regulation and expression of CYP3A4 in hepatocytes.
Gómez-Lechón et al., Valencia, Spain. In Curr Drug Metab, 2007
Several transcription factors and nuclear receptors contribute to the hepatic-specific expression of CYP3A4, including: C/EBPalpha, C/EBPbeta, HNF4alpha, HNF3gamma, CAR and PXR.
The Foxa family of transcription factors in development and metabolism.
Kaestner et al., Philadelphia, United States. In Cell Mol Life Sci, 2006
During this time its three members, Foxa1, Foxa2 and Foxa3, have been found to play important roles in multiple stages of mammalian life, beginning with early development, continuing during organogenesis, and finally in metabolism and homeostasis in the adult.
Winged-helix transcription factors and pancreatic development.
Kaestner et al., Philadelphia, United States. In Clin Sci (lond), 2005
The three Fox (forkhead box) group A genes, Foxa1, Foxa2 and Foxa3, are expressed in embryonic endoderm, the germ layer that gives rise to the digestive system, and contribute to the specification of the pancreas and the regulation of glucose homoeostasis.
Human FOX gene family (Review).
Katoh et al., Japan. In Int J Oncol, 2004
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD5 (FOXD4L1), FOXD6 (FOXD4L3), FOXE1, FOXE2, FOXE3, FOXF1, FOXF2, FOXG1 (FOXG1B), FOXH1, FOXI1, FOXJ1, FOXJ2, FOXJ3, FOXK1, FOXK2, FOXL1, FOXL2, FOXM1, FOXN1, FOXN2 (HTLF), FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1), FOXN6 (FOXR2), FOXO1 (FOXO1A), FOXO2 (FOXO6), FOXO3 (FOXO3A), FOXO4 (MLLT7), FOXP1, FOXP2, FOXP3, FOXP4, and FOXQ1.
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