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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Forkhead box O3A

forkhead box O3A
Top mentioned proteins: FOXO3a, CAN, V1a, AP-1, Insulin
Papers on forkhead box O3A
Markers of autophagy are adapted to hyperglycaemia in skeletal muscle in type 2 diabetes.
New
Højlund et al., Odense, Denmark. In Diabetologia, Sep 2015
RESULTS: Muscle transcript levels of autophagy-related genes (ULK1, BECN1, PIK3C3, ATG5, ATG7, ATG12, GABARAPL1, MAP1LC3B, SQSTM1, TP53INP2 and FOXO3A [also known as FOXO3]), including some specific for mitophagy (BNIP3, BNIP3L and MUL1), and protein abundance of autophagy-related gene (ATG)7 and Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3), as well as content and phosphorylation of forkhead box O3A (FOXO3A) were similar among the groups.
Impaired interferon signaling in chronic hepatitis C patients with advanced fibrosis via the transforming growth factor beta signaling pathway.
Kaneko et al., Kanazawa, Japan. In Hepatology, 2014
Here, the effect of transforming growth factor (TGF)-β signaling on IFN signaling and hepatitis C virus (HCV) replication was examined in Huh-7.5 cells by evaluating the expression of forkhead box O3A (Foxo3a), suppressor of cytokine signaling 3 (Socs3), c-Jun, activating transcription factor 2, ras homolog enriched in brain, and mTORC1.
Downregulation of E3 ubiquitin ligases and mitophagy-related genes in skeletal muscle of physically inactive, frail older women: a cross-sectional comparison.
Marcus et al., Salt Lake City, United States. In J Gerontol A Biol Sci Med Sci, 2014
and forkhead box O3A (FOXO3A) gene expression (p = .047)
Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells.
Mi et al., Chongqing, China. In Cell Death Dis, 2013
Meanwhile, RSV remarkably reduced mtROS generation by promoting Sirt3 enrichment within the mitochondria and subsequent upregulation of forkhead box O3A (FoxO3A)-mediated mitochondria-encoded gene expression of ATP6, CO1, Cytb, ND2 and ND5, thereby leading to increased complex I activity and ATP synthesis.
Aldose reductase inhibition prevents colon cancer growth by restoring phosphatase and tensin homolog through modulation of miR-21 and FOXO3a.
Srivastava et al., Galveston, United States. In Antioxid Redox Signal, 2013
Further, AR inhibition also increased phosphatase and tensin homolog (PTEN) (a direct target of miR-21) and forkhead box O3A (FOXO3a) in colon cancer cells.
Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B.
Nebel et al., Kiel, Germany. In Eur J Hum Genet, 2013
Our study demonstrates that the genetic investigation of forkhead box O3A gene (FOXO3A), a validated human longevity gene, is greatly hampered by the fact that its exonic regions have 99% sequence homology with the FOXO3B pseudogene.
Anthocyanins in the black soybean (Glycine max L.) protect U2OS cells from apoptosis by inducing autophagy via the activation of adenosyl monophosphate-dependent protein kinase.
Kim et al., Seoul, South Korea. In Oncol Rep, 2012
In addition, siRNA against forkhead box O3A (FOXO3a), a downstream target of AMPK, suppressed ATC-induced autophagy and p27KIP1 siRNA increased apoptosis in ATC-treated cells.
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.
Impact
Duan et al., Baltimore, United States. In Nat Med, 2012
Notably, we show that mutant HTT interacts with Sirt1 and inhibits Sirt1 deacetylase activity, which results in hyperacetylation of Sirt1 substrates such as forkhead box O3A (Foxo3a), thereby inhibiting its pro-survival function.
Knockdown of FoxO3a induces increased neuronal apoptosis during embryonic development in zebrafish.
GeneRIF
Peng et al., Guangzhou, China. In Neurosci Lett, 2010
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
Glycome and transcriptome regulation of vasculogenesis.
Sengupta et al., Boston, United States. In Circulation, 2009
Specifically, we demonstrated that forkhead box O3A/5 proteins and insulin-like growth factor were key downstream signals in this process.
Association of FOXO3A variation with human longevity confirmed in German centenarians.
Nebel et al., Kiel, Germany. In Proc Natl Acad Sci U S A, 2009
The human forkhead box O3A gene (FOXO3A) encodes an evolutionarily conserved key regulator of the insulin-IGF1 signaling pathway that is known to influence metabolism and lifespan in model organisms.
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