Multiple cystic lung disease.
Rio de Janeiro, Brazil. In Eur Respir Rev, Dec 2015
The main diseases in this group that are discussed in this review are lymphangioleiomyomatosis, pulmonary Langerhans cell histiocytosis and folliculin gene-associated syndrome (Birt-Hogg-Dubé); other rare causes of cystic lung disease, including cystic metastasis of sarcoma, are also discussed.
Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome.
Bethesda, United States. In Nat Rev Urol, Oct 2015
Germline mutations in the FLCN gene on chromosome 17 are responsible for BHD syndrome--BHD-associated renal tumours display inactivation of the wild-type FLCN allele by somatic mutation or chromosomal loss, confirming that FLCN is a tumour suppressor gene that fits the classic two-hit model.
[Prevention and Treatment of Atherosclerosis by Three Different Chinese Medical Compounds: a Mechanism Study].
In Zhongguo Zhong Xi Yi Jie He Za Zhi, Oct 2015
OBJECTIVE: To study the effect of Buyang Huanwu Decoction (BHD), Xuefu Zhuyu Decoction (XZD), and Sijunzi Decoction (SD) contained serums on expressions of Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signals, lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), tumor necrosis factor-α (TNF-α), vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and to explore possible anti-atherosclerotic mechanisms.
Oncotargets in different renal cancer subtypes.
Zürich, Switzerland. In Curr Drug Targets, 2014
FLCN, TSC1, TSC2, TFE3, TFEB, MITF, FH, SDHB, SDHD, MET, and PTEN and we review their role in renal tumor carcinogenesis, prognosis, and targeted therapy.
Birt-Hogg-Dubé syndrome: diagnosis and management.
Amsterdam, Netherlands. In Lancet Oncol, 2009
The condition is caused by germline mutations in the FLCN gene, which encodes folliculin; the function of this protein is largely unknown, although FLCN has been linked to the mTOR pathway.
Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis.
Columbus, United States. In Jama, 2005
Germline analysis of PTEN, BMPR1A, STK11 (sequence, deletion), SMAD4, and ENG (sequence), specific exon screening of BRAF, MYH, and BHD, and rereview of polyp histology results were performed.