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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Folate receptor 1

folate receptor, MOv18, FR-alpha
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, HAD, OUT
Papers on folate receptor
Imaging cancer cells expressing the folate receptor with carbon dots produced from folic acid.
New
Jelinek et al., Israel. In Chembiochem, Feb 2016
We show that fluorescent carbon dots (C-dots) synthesized from folic acid can serve as an effective vehicle for imaging cancer cells expressing the folate receptor on their surface.
Combinatorial optimization of sequence-defined oligo(ethanamino)amides for folate receptor-targeted pDNA and siRNA delivery.
New
Wagner et al., In Bioconjug Chem, Feb 2016
UNASSIGNED: Cationic polymers present a versatile platform for the non-viral delivery of therapeutic nucleic acids.
Folate-targeted nanoparticles for rheumatoid arthritis therapy.
Review
New
Cavaco-Paulo et al., Braga, Portugal. In Nanomedicine, Jan 2016
Activated macrophages are critical in the pathogenesis of RA and have been shown to specifically express a receptor for the vitamin folic acid (FA), folate receptor β (FRβ).
A study of the synergistic effect of folate-decorated polymeric micelles incorporating Hydroxycamptothecin with radiotherapy on xenografted human cervical carcinoma.
New
Wu et al., China. In Colloids Surf B Biointerfaces, Jan 2016
We found that FA-conjugated micelles had superior cytotoxicity against HeLa cells compared to non-conjugated micelles, and that they exerted this effect by folate receptor (FR)-mediated endocytosis.
Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic.
New
Wang et al., Chapel Hill, United States. In Biomaterials, Jan 2016
The folate receptor (FR) is known to be overexpressed in several tumor types, including head-and-neck, prostate, and non-small cell lung cancers.
Baicalin loaded in folate-PEG modified liposomes for enhanced stability and tumor targeting.
New
Zou et al., Shanghai, China. In Colloids Surf B Biointerfaces, Dec 2015
Several liposome systems of different composition i.e., lipid/cholesterol (L), long-circulating stealth liposome (L-PEG) and folate receptor (FR)-targeted liposome (L-FA) have been used as the drug carrier for BAI.
Preclinical development of small-molecular-weight folate-based radioconjugates: a pharmacological perspective.
Review
New
Müller et al., Switzerland. In Q J Nucl Med Mol Imaging, Sep 2015
The folate receptor (FR) has attracted attention as a target structure because of its frequent expression in cancer cells (FR-α) and activated macrophages (FR-β).
Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy.
Review
New
Hojjat-Farsangi et al., Shīrāz, Iran. In Tumour Biol, Aug 2015
It has been shown that cancer cells over-express folate receptor (FR) in order to improve their growth.
Potential for monocyte recruitment by IgE immunotherapy for cancer in a rat model of tumour metastasis.
New
Impact
Karagiannis et al., London, United Kingdom. In Lancet, Mar 2015
MOv18IgE, which targets folate receptor α (FRα), is a novel system to model this hypothesis.
Development of Cyclodextrin-based Cancer Treatment.
Review
Motoyama, Kumamoto, Japan. In Yakugaku Zasshi, 2014
For instance, folic acid (FA) as a tumor-targeting ligand is widely used because of overexpression of folate receptor-α (FR-α) in various kinds of epithelial tumor cells.
A current review of folate receptor alpha as a potential tumor target in non-small-cell lung cancer.
Review
Wang et al., Jinan, China. In Drug Des Devel Ther, 2014
Folate receptor alpha (FRA) is overexpressed in the majority of NSCLC, particularly in lung adenocarcinomas.
Juno is the egg Izumo receptor and is essential for mammalian fertilization.
Impact
Wright et al., Cambridge, United Kingdom. In Nature, 2014
Here we identify folate receptor 4 (Folr4) as the receptor for Izumo1 on the mouse egg, and propose to rename it Juno.
PRECEDENT: a randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer.
Impact
Messmann et al., Charlotte, United States. In J Clin Oncol, 2014
PURPOSE: Vintafolide (EC145) is a folic acid-desacetylvinblastine conjugate that binds to the folate receptor (FR), which is expressed on the majority of epithelial ovarian cancers.
Structural basis for molecular recognition of folic acid by folate receptors.
Impact
Melcher et al., Grand Rapids, United States. In Nature, 2013
The extensive interactions between the receptor and ligand readily explain the high folate-binding affinity of folate receptors and provide a template for designing more specific drugs targeting the folate receptor system.
Phase I study of folate conjugate EC145 (Vintafolide) in patients with refractory solid tumors.
Impact
Sausville et al., Baltimore, United States. In J Clin Oncol, 2012
PURPOSE: EC145 (vintafolide), a conjugate of folic acid and the vinca alkaloid desacetylvinblastine hydrazide (DAVLBH), is a ligand for the folate receptor (FR), with activity against FR-positive tumor xenografts in vivo.
Molecular characterization of folate receptor 1 mutations delineates cerebral folate transport deficiency.
GeneRIF
Steinfeld et al., Göttingen, Germany. In Brain, 2012
studies suggest that different clinical severities do not necessarily correlate with residual function of folate receptor alpha mutants.
Serous ovarian carcinoma patients with high alpha-folate receptor had reducing survival and cytotoxic chemo-response.
GeneRIF
Cheng et al., Taipei, Taiwan. In Mol Oncol, 2012
alpha-FR can be a potential biomarker for the prediction of chemotherapeutic responses and clinical prognosis.
Differential expression of folate receptor alpha in pituitary adenomas and its relationship to tumor behavior.
GeneRIF
Wang et al., Beijing, China. In Neurosurgery, 2012
FRalpha may play an important role in the development and progression of NFAs.
High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and EGFR [corrected] mutation.
GeneRIF
Wistuba et al., Houston, United States. In J Thorac Oncol, 2012
High folate receptor alpha is associated with adenocarcinoma in non-small-cell lung carcinoma and and EGFR [corrected] mutation.
A folate receptor alpha double-mutated haplotype 1816delC-1841A is distributed throughout Eurasia and associated with lower erythrocyte folate levels.
GeneRIF
Salumets et al., Örebro, Sweden. In Mol Biol Rep, 2012
An ancient double-mutated haplotype 1816delC-1841A in the FOLR1 gene, is demonstrated.
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