gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Wings apart-like homolog

FOE, WAPL
Top mentioned proteins: Pds5, CAN, Scc1, P35, separase
Papers on FOE
α-Pinene, linalool, and 1-octanol contribute to the topical anti-inflammatory and analgesic activities of frankincense by inhibiting COX-2.
New
Tang et al., Wuhan, China. In J Ethnopharmacol, Jan 2016
ETHNOPHARMACOLOGICAL RELEVANCE: Frankincense oil and water extracts (FOE, FWE) have long been used for external treatment of inflammation and pain.
SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A-B56.
New
Poon et al., Hong Kong, Hong Kong. In Cell Cycle, Jan 2016
Shugoshin (SGO1) plays a pivotal role in sister chromatid cohesion during mitosis by protecting the centromeric cohesin from mitotic kinases and WAPL.
DNA Entry into and Exit out of the Cohesin Ring by an Interlocking Gate Mechanism.
New
Impact
Uhlmann et al., London, United Kingdom. In Cell, Jan 2016
DNA-sensing lysines trigger ATP hydrolysis to open the SMC head interface, whereas the Wapl subunit disengages kleisin, but only after ATP rebinds.
IL-17 Blockade in Psoriasis: Friend or Foe in Cardiovascular Risk?
New
Selores et al., Porto, Portugal. In Am J Clin Dermatol, Dec 2015
UNASSIGNED: Psoriasis is a chronic, immune-mediated inflammatory disorder associated with systemic inflammation and a significantly increased risk of cardiovascular disease.
Lithium in the Kidney: Friend and Foe?
New
de Groot et al., Nijmegen, Netherlands. In J Am Soc Nephrol, Dec 2015
UNASSIGNED: Trace amounts of lithium are essential for our physical and mental health, and administration of lithium has improved the quality of life of millions of patients with bipolar disorder for >60 years.
Treg(s) in Cancer: Friends or Foe?
Review
New
Wolf et al., Bonn, Germany. In J Cell Physiol, Nov 2015
Immune escape is a hallmark of cancer.
Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?
Review
New
Hardie, Dundee, United Kingdom. In Clin Cancer Res, Oct 2015
AMPK can therefore be either a friend or a foe in cancer, depending on the context.
M1 and M2 immune activation in Parkinson's Disease: Foe and ally?
Review
New
West et al., Birmingham, United States. In Neuroscience, Sep 2015
Parkinson's Disease (PD) is a chronic and progressive neurodegenerative disorder of unknown etiology.
Soluble elastin peptides in cardiovascular homeostasis: Foe or ally.
Review
New
Qin, San Antonio, United States. In Peptides, May 2015
Elastin peptides, also known as elastin-derived peptides or elastokines, are soluble polypeptides in blood and tissue.
The Role of BMP Signaling and NF-κB Signaling on Osteoblastic Differentiation, Cancer Development, and Vascular Diseases--Is the Activation of NF-κB a Friend or Foe of BMP Function?
Review
Jimi, Kitakyūshū, Japan. In Vitam Horm, 2014
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β family, were first identified as potent inducers of ectopic bone formation when implanted into muscle tissue.
Involvement of the Cohesin Cofactor PDS5 (SPO76) During Meiosis and DNA Repair in Arabidopsis thaliana.
Santos et al., Madrid, Spain. In Front Plant Sci, 2014
In yeast, the complex Wapl-Pds5 controls cohesion maintenance and colocalizes with cohesin complexes into chromosomes.
Wapl is an essential regulator of chromatin structure and chromosome segregation.
Impact
Peters et al., Vienna, Austria. In Nature, 2013
Using conditional mutagenesis in the mouse, here we show that depletion of the cohesin-associated protein Wapl stably locks cohesin on DNA, leads to clustering of cohesin in axial structures, and causes chromatin condensation in interphase chromosomes.
Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis.
Impact
Yu et al., Dallas, United States. In Nat Cell Biol, 2013
The complex of shugoshin and protein phosphatase 2A (SGO1-PP2A) protects cohesin at centromeres from premature removal by mitotic kinases and WAPL in prophase.
Cohesin's DNA exit gate is distinct from its entrance gate and is regulated by acetylation.
Impact
Nasmyth et al., Oxford, United Kingdom. In Cell, 2012
Cohesion requires acetylation of Smc3 by Eco1, whose role is to counteract an inhibitory (antiestablishment) activity associated with cohesin's Wapl subunit.
Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.
GeneRIF
Yu et al., Dallas, United States. In Genes Dev, 2012
Depletion of Wapl, a negative cohesin regulator, rescues sister chromatid homologous recombination defects of Mms21-deficient or Scc1 mutant-expressing cells
Sororin mediates sister chromatid cohesion by antagonizing Wapl.
Impact
Peters et al., Vienna, Austria. In Cell, 2010
Cohesin-DNA interactions can be reversed by the cohesion-associated protein Wapl, whereas a stably DNA-bound form of cohesin is thought to mediate cohesion.
Expression of various types of alternatively spliced WAPL transcripts in human cervical epithelia.
GeneRIF
Kuroda et al., Tokyo, Japan. In Gene, 2008
isolated a large number of additional alternatively spliced WAPL variants from various cervical epithelia. Each variant consists of a variable 5'-terminal region and the conserved remainder.
Unscheduled overexpression of human WAPL promotes chromosomal instability.
GeneRIF
Kuroda et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2007
our study suggests that unscheduled overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability.
Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.
GeneRIF
Hirano et al., New York City, United States. In Curr Biol, 2007
Wapl is a new regulator of sister chromatid resolution and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits
Wapl controls the dynamic association of cohesin with chromatin.
Impact
GeneRIF
Peters et al., Vienna, Austria. In Cell, 2007
Wapl is required to unlock cohesin from a particular state in which it is stably bound to chromatin.
share on facebooktweetadd +1mail to friends