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PTK2 protein tyrosine kinase 2

focal adhesion kinase, FAK, Focal Adhesion Kinase 1
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: V1a, Akt, Src, CAN, Actin
Papers using focal adhesion kinase antibodies
Hyaluronic acid and thrombin upregulate MT1-MMP through PI3K and Rac-1 signaling and prime the homing-related responses of cord blood hematopoietic stem/progenitor cells
Supplier
Sheu Ming-Jyh et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2010
... Anti-ERK1/2, anti-PI3K, antifocal adhesion kinase (FAK), anti-p-FAK, and horseradish peroxidase-conjugated goat anti-mouse IgG antibody were purchased from Santa Cruz Biotechnology Co ...
Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands.
Supplier
Cookson Mark R., In PLoS ONE, 2008
... total paxillin, total p130Cas (Cell Signaling), and phospho-paxillin (Y118), phospho-p130Cas (Y410), total-Pyk2, phospho-Pyk2 (Y402) and phospho-FAK (Y577/Y578) from (BD Biosciences, San Jose, CA, USA) ...
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer
Supplier
Rondé Philippe et al., In Journal of Oncology, 2008
... Matrigel and mouse monoclonal antibody (Ab) directed against FAK kinase domain (amino acids 354–533) were from BD Biosciences.
Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer
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Schiff Rachel et al., In Breast Cancer Research : BCR, 2008
... The β1 inhibitory antibody AIIB2 (Aragen Bioscience, Morgan Hill, CA, USA, used at 0.24 mg/ml), FAK inhibitor PF 573228 (Tocris Bioscience, Bristol, UK, used ...
Mechanism of dietary salt-mediated increase in intravascular production of TGF-ss1.
Supplier
Means Robert E., In PLoS ONE, 2007
... The following antibodies were purchased, rabbit anti-FAK IgG (Upstate Biotechnology, Cat# 06-543); mouse mAb anti-FAK (Santa Cruz Biotechnology; clone # H-1); rabbit anti-phospho-FAK ...
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Papers on focal adhesion kinase
KLF5 promotes cell migration by up-regulating FYN in bladder cancer cells.
New
Guo et al., Xi'an, China. In Febs Lett, Feb 2016
We found that KLF5 increases cell migration and lamellipodia formation, expression of FYN and phosphorylation of FAK in bladder cancer cells.
The transport mechanism of integrin αvβ3 receptor targeting nanoparticles in Caco-2 cells.
New
Huang et al., Chengdu, China. In Int J Pharm, Feb 2016
Our results showed FQS peptide mediated multiple endocytosis pathways and could activate integrin αvβ3 receptor by interacting with FAK and Src-family kinases to induce receptor-mediated endocytosis of the NPs.
Tumor suppressive microRNA-138 inhibits metastatic potential via the targeting of focal adhesion kinase in Ewing's sarcoma cells.
New
Tsumura et al., Ōita, Japan. In Int J Oncol, Feb 2016
One miRNA, miR‑138, was significantly downregulated, whereas the expression of focal adhesion kinase (FAK) was significantly upregulated in all tested ES cells.
The role of the Src Homology-2 domain containing protein B (SHB) in β cells.
Review
New
Åkerblom et al., Uppsala, Sweden. In J Mol Endocrinol, Jan 2016
Specifically, first-phase insulin secretion in response to glucose was impaired and this effect was related to altered characteristics of focal adhesion kinase activation modulating signaling through Akt, ERK, β catenin and cAMP.
Syntenin is expressed in human gliomas and may correlate with tumor migration.
New
Wang et al., Chongqing, China. In Arch Med Sci, Jan 2016
Phosphorylated FAK in human gliomas was examined by western blot.
Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly.
New
Impact
Humphries et al., Manchester, United Kingdom. In Nat Cell Biol, Dec 2015
The consensus adhesome is likely to represent a core cell adhesion machinery, centred around four axes comprising ILK-PINCH-kindlin, FAK-paxillin, talin-vinculin and α-actinin-zyxin-VASP, and includes underappreciated IAC components such as Rsu-1 and caldesmon.
Integrin endosomal signalling suppresses anoikis.
New
Impact
Ivaska et al., Turku, Finland. In Nat Cell Biol, Nov 2015
We show that active focal adhesion kinase (FAK), an established marker of integrin-ECM downstream signalling, localizes with active integrins on endosomes.
How actin/myosin crosstalks guide the adhesion, locomotion and polarization of cells.
Review
New
Sackmann, München, Germany. In Biochim Biophys Acta, Nov 2015
Protrusion forces are generated by actin gelation triggered by molecular machines (focal adhesion kinase (FAK), Src-kinases and associated adaptors) which assemble around newly formed integrin clusters.
[Periostin in the Pathogenesis of Proliferative Vitreoretinopathy].
Review
New
Ishikawa, In Nihon Ganka Gakkai Zasshi, Nov 2015
In vitro, periostin increased proliferation, adhesion, migration and collagen production in primary human RPE cells through integrin αV-mediated FAK and AKT phosphorylation.
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members.
Review
New
Golemis et al., Philadelphia, United States. In Gene, Nov 2015
All family members are intermediates in integrin-dependent signaling pathways mediated at focal adhesions, and associate with FAK and SRC family kinases to activate downstream effectors regulating the actin cytoskeleton.
Nuclear FAK controls chemokine transcription, Tregs, and evasion of anti-tumor immunity.
New
Impact
Frame et al., Needham, United States. In Cell, Oct 2015
Focal adhesion kinase (FAK) promotes anti-tumor immune evasion.
Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour.
New
Impact
Pelkmans et al., Zürich, Switzerland. In Nature, Aug 2015
It acts by sensing the local crowding of a single cell through its ability to spread and activate focal adhesion kinase (FAK, also known as PTK2), resulting in adaptation of genes controlling membrane homeostasis.
Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling.
New
Impact
Sahai et al., Kyoto, Japan. In Cancer Cell, May 2015
This is linked to "paradoxical" activation of melanoma-associated fibroblasts by PLX4720 and the promotion of matrix production and remodeling leading to elevated integrin β1/FAK/Src signaling in melanoma cells.
The role of periostin in neoplastic processes.
Review
Dziegiel et al., Wrocław, Poland. In Folia Histochem Cytobiol, 2014
Due to its characteristic molecular structure containing integrin-binding domains, periostin is capable of binding to multiple integrin receptors (αvβ3, αvβ5, α6β4), thus affecting the regulation of the intracellular signaling pathways associated with protein kinases PI3K/AKT and focal adhesion kinase (FAK).
Inhibition by a retinoic acid receptor γ agonist of extracellular matrix remodeling mediated by human Tenon fibroblasts.
Sonoda et al., Ube, Japan. In Mol Vis, 2014
Phosphorylation of focal adhesion kinase (FAK) was examined with immunoblot analysis, and production of fibronectin and type I collagen was measured with immunoassays.
Thioredoxin reductase linked to cytoskeleton by focal adhesion kinase reverses actin S-nitrosylation and restores neutrophil β(2) integrin function.
GeneRIF
Bogush et al., Philadelphia, United States. In J Biol Chem, 2012
Thioredoxin reductase linked to cytoskeleton by focal adhesion kinase reverses actin S-nitrosylation and restores neutrophil beta(2) integrin function.
Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth.
GeneRIF
Rico et al., Alacant, Spain. In Development, 2012
FAK controls filopodia formation and actin nucleation during axonal development.
In oral squamous cell carcinoma, high FAK expression is correlated with low P53 expression.
GeneRIF
de Vicente et al., Gijón, Spain. In Virchows Arch, 2012
our results support the hypothesis that FAK activity might be involved in the down-regulation of p53 expression in oral squamous cell carcinoma
Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat.
GeneRIF
Cheng et al., New York City, United States. In Proc Natl Acad Sci U S A, 2012
FAK-Tyr(407) phosphorylation promotes BTB integrity by strengthening the actin filament-based cytoskeleton.
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
GeneRIF
Schlaepfer et al., San Diego, United States. In J Cell Biol, 2012
studies reveal new developmental and anti-inflammatory roles for kinase-inhibited FAK in limiting VCAM-1 production via nuclear localization and promotion of GATA4 turnover
More papers using focal adhesion kinase antibodies
Rac and Rap GTPase activation assays.
Supplier
Hartl Dominik, In PLoS ONE, 2006
... MO); p38 MAPK, phospho-p38 MAPK (Thr180/Thr182), p44/42 MAP kinase, phospho-p44/42, pSAPK/JNK (Thr183/Thr185,) SAPK/JNK (56G8), and FAK were from Cell Signaling (Danvers, MA); paxillin, E-cadherin, ...
Src kinase activity and SH2 domain regulate the dynamics of Src association with lipid and protein targets
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Henis Yoav I. et al., In The Journal of Cell Biology, 2006
... Murine anti-paxillin and anti-FAK were obtained from BD Biosciences.
A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions
Supplier
Alaoui-Jamali M A et al., In British Journal of Cancer, 2006
... Antibodies to RhoA and phospho-FAK-Y925 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth.
Supplier
Feghali-Bostwick Carol, In PLoS ONE, 2006
... For FAK inhibition and HSPGs cleavage experiments, after 24 h of spreading, cells in gels were treated with either 10 µM PF-228 (Santa Cruz Biotechnology) or 6.7 IU/L heparinase ...
Adrm1, a putative cell adhesion regulating protein, is a novel proteasome-associated factor
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Mandoki Juan J et al., In Cancer Cell International, 2005
... Antibodies against paxillin (sc-5574 rabbit polyclonal), β-tubulin (D-10 mouse monoclonal), FAK (H-1 mouse monoclonal), and phosphotyrosine (PY20 mouse monoclonal) as well as siRNAs were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Epigenetic disruption of two proapoptotic genes MAPK10/JNK3 and PTPN13/FAP-1 in multiple lymphomas and carcinomas through hypermethylation of a common bidirectional promoter
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Wu Chuanyue et al., In The Journal of Cell Biology, 2005
... Rabbit polyclonal anti-Src, anti-pY416 Src, anti-pY527 Src, rabbit anti-FAK, and anti-pY566/577-FAK antibodies were purchased from Cell Signaling Technology ...
PINCH-1 expression during early avian embryogenesis: implications for neural crest and heart development.
Supplier
Jagetia Ganesh Chandra, In PLoS ONE, 2005
... Antibodies against ILK, FAK, GSK3β (BD, Heidelberg, Germany), α-Parvin (Acris, Hiddenhausen, Germany), FAK Tyr397 ...
Type IV collagenase (matrix metalloproteinase-2 and -9) in prostate cancer
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Koul Hari K et al., In Molecular Cancer, 2003
... PDEF and phospho FAK antibodies were from Santa Cruz Biotechnology (CA, USA) ...
uPAR promotes formation of the p130Cas–Crk complex to activate Rac through DOCK180
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Marshall Christopher J. et al., In The Journal of Cell Biology, 2002
... (P1F6), antivitronectin (clone BV2; Millipore), anti-p130Cas, anti-Crk, anti-FAK (BD Biosciences), anti–α-tubulin, anti-total, phosphoERK (Sigma-Aldrich), ...
Protein kinase signaling in the modulation of microvascular permeability
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Mehta Dolly et al., In The Journal of Experimental Medicine, 2001
... Anti–phospho FAK PY397 was purchased from Invitrogen, anti–β catenin Ab was obtained from Abcam.
Integrin-mediated adhesion regulates membrane order
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Schwartz Martin A. et al., In The Journal of Cell Biology, 2001
... Antibodies against Cav1, pYCav1, and FAK were all obtained from BD Biosciences.
Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin
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Poole Alastair W. et al., In Biochemical and Biophysical Research Communications, 2001
... The focal adhesion kinase (FAK) inhibitor PF-573,228 (3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone) was purchased from Tocris (Bristol, UK) ...
Subtype specific roles of mitogen activated protein kinases in L6E9 skeletal muscle cell differentiation
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Dey Chinmoy S et al., In BMC Cell Biology, 2001
... Anti-FAK antibody was from Santa Cruz Biotechnology (CA, USA) ...
FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion
Supplier
Alaoui-Jamali Moulay A. et al., In The Journal of Cell Biology, 2001
... polyclonal anti–ErbB-2 (Ab-1; Oncogene Research Products); polyclonal anti–ErbB-3 (clone C-17), polyclonal anti-FAK (A-17; C-20), and antiphospho–FAK-Y925 (Santa Cruz Biotechnology, Inc.); antiphospho–FAK-Y397 and antiphospho–FAK-Y861 ...
Integrin α2β1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCγ2
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Watson Steve P. et al., In The Journal of Cell Biology, 2001
... integrin mAb (HMα2), hamster IgG1κ (A19-3), anti–SLP-76 mAb, and anti-FAK mAb (clone 8) for Western blotting were from Becton Dickinson.
FAK induces expression of Prx1 to promote tenascin-C–dependent fibroblast migration
Supplier
Jones Peter Lloyd et al., In The Journal of Cell Biology, 2000
... Rabbit polyclonal α-FAK (C-20) and normal rabbit IgG were obtained from Santa Cruz Biotechnology, Inc ...
Sustained Activation of Cell Adhesion Is a Differentially Regulated Process in B Lymphopoiesis
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Silberstein Leslie E. et al., In The Journal of Experimental Medicine, 1998
... Roberts, Dana Farber Cancer Institute, Boston, MA) and rabbit anti–FAK polyclonal antibody (Santa Cruz Biotechnology, Inc.) ...
Focal adhesion kinase promotes phospholipase C-gamma1 activity
Supplier
Huttenlocher Anna et al., In The Journal of Cell Biology, 1998
... The following rabbit polyclonal antibodies were used: anti-p34Arc, anti-pY421 cortactin (Millipore), anti-FAK (clone C-20), anti-Tks5/FISH (clone M-300; Santa Cruz Biotechnology, Inc.), anti-pY31 paxillin, anti-pY397 ...
Protein-tyrosine phosphatase SHP-2 regulates cell spreading, migration and focal adhesion
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Tremblay Michel L. et al., In The Journal of Cell Biology, 1997
... The following antibodies were purchased as indicated: rabbit anti–FAK (A17) from Santa Cruz Biotechnology, Inc. ...
Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity
Supplier
Wu Chuanyue et al., In The Journal of Cell Biology, 1997
... Rabbit polyclonal anti-FAK antibody C-20 was purchased from Santa Cruz Biotechnology, Inc ...
Developmental expression of the mu, kappa, and delta opioid receptor mRNAs in mouse
Supplier
Wei Li-Na et al., In The Journal of Cell Biology, 1997
... PF 573228 and FAK inhibitor 14 were obtained from Tocris Bioscience ...
Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling
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Cheresh David A. et al., In The Journal of Cell Biology, 1996
... A rabbit polyclonal antibody raised against the COOH terminus of human FAK (C-20; Santa Cruz Biotechnology) was used for immunoprecipitations ...
Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn
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Wang Qiuyan et al., In Journal of Experimental & Clinical Cancer Research : CR, 1995
... Monoclonal antibodies against human integrin α5 and β1, β-actin, rabbit polyclonal antibodies to human FAK, and Protein G PLUS agarose were from Santa Cruz Biotechnology Inc ...
Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold
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Klemke Richard L. et al., In The Journal of Cell Biology, 1995
... Antibodies to myc (9E10), ERK2, and FAK were from Santa Cruz Biotechnology.
Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: an in vitro model of osteoblast development
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Marie Pierre J et al., In BMC Cell Biology, 1991
... does not lead to specific degradation of any known cellular mRNA), ITGB1 shRNA and human FAK shRNA lentiviral particles (mixtures of viral particles containing 3 target-specific constructs that encode shRNA designed to knock down gene expression) were obtained from Santa Cruz Biotechnology (Heidelberg, Germany) ...
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.
Supplier
Hotchin Neil A., In PLoS ONE, 1987
... The blotting was conducted using mouse anti-V5 (Invitrogen), anti-human STC1 (R&D), human p-FAK (pY397) (BD Biosciences), rabbit anti-human p-GSK3β (Ser9), ...
Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons.
Supplier
Mei Lin, In PLoS ONE, 1987
... Dynein intermediate chain (MAB 1618, Chemicon), actin (C4, MAB1501, Chemicon), Vimentin (Abcam, Chemicon), Peripherin (Chemicon), FAK (N-20, Santa Cruz Biotechnology), Acetylated-Tubulin (Abcam), Tyrosinated Tubulin ...
Eosinophil adhesion under flow conditions activates mechanosensitive signaling pathways in human endothelial cells
Supplier
Patel Kamala D. et al., In The Journal of Experimental Medicine, 1984
... Antibodies directed against phospho-ERK1/2, phospho-p38, p38, phospho-JNK, phospho-FAK, phospho-paxillin, and FAK were purchased from Cell Signaling Technology, Inc ...
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