A cell biological view of the siderophore pyochelin iron uptake pathway in Pseudomonas aeruginosa.
Illkirch-Graffenstaden, France. In Environ Microbiol, 2015
Using (55) Fe uptake and binding assays, we showed that PCH-Fe uptake in P. aeruginosa involves, in addition to the highly studied outer membrane transporter FptA, the inner membrane permease FptX, which recognizes PCH-(55) Fe with an affinity of 0.6 ± 0.2 nM and transports the ferri-siderophore complex from the periplasm into the cytoplasm: fptX deletion inhibited (55) Fe accumulation in the bacterial cytoplasm.
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies.
San Francisco, United States. In Cancer Cell, 2006
Nine of these (FGFR1, IKBKB, ERBB2, PROCC, ADAM9, FNTA, ACACA, PNMT, and NR1D1) are considered druggable.