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Farnesyltransferase, CAAX box, alpha

Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: V1a, ACID, CAN, SET, HAD
Papers on FNTA
A cell biological view of the siderophore pyochelin iron uptake pathway in Pseudomonas aeruginosa.
Schalk et al., Illkirch-Graffenstaden, France. In Environ Microbiol, 2015
Using (55) Fe uptake and binding assays, we showed that PCH-Fe uptake in P. aeruginosa involves, in addition to the highly studied outer membrane transporter FptA, the inner membrane permease FptX, which recognizes PCH-(55) Fe with an affinity of 0.6 ± 0.2 nM and transports the ferri-siderophore complex from the periplasm into the cytoplasm: fptX deletion inhibited (55) Fe accumulation in the bacterial cytoplasm.
Pore-forming pyocin S5 utilizes the FptA ferripyochelin receptor to kill Pseudomonas aeruginosa.
Cornelis et al., Brussels, Belgium. In Microbiology, 2014
The majority of S5-resistant mutants had an insertion in the fptA gene encoding the receptor for the siderophore pyochelin.
Synthesis and biological properties of thiazole-analogues of pyochelin, a siderophore of Pseudomonas aeruginosa.
Mislin et al., Illkirch-Graffenstaden, France. In Bioorg Med Chem Lett, 2014
FptA is the outer membrane transporter responsible of ferric-pyochelin uptake in P. aeruginosa.
Genome-wide screen for modulation of hepatic apolipoprotein A-I (ApoA-I) secretion.
Michael et al., Indianapolis, United States. In J Biol Chem, 2013
Repression of farnesyltransferase (FNTA) by siRNA and the enzyme inhibitor manumycin A caused elevation of ApoA-I secretion from hepatocytes and from transgenic mice expressing hApoA-I and cholesterol ester transfer protein transgenes.
Alteration of mevalonate pathway related enzyme expressions in pressure overload-induced cardiac hypertrophy and associated heart failure with preserved ejection fraction.
Hu et al., Hangzhou, China. In Cell Physiol Biochem, 2012
The tissue of the heart and the abdominal aorta proximal to the coarctation showed over-expression of several enzymes, including 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR), farnesyl diphosphate synthase (FDPS), farnesyltransferase-α (FNTA), farnesyltransferase-β (FNTB), geranylgeranyltransferase type I (GGTase-I) and the activation of their downstream proteins was enhanced.
Th17-stimulating protein vaccines confer protection against Pseudomonas aeruginosa pneumonia.
Priebe et al., Boston, United States. In Am J Respir Crit Care Med, 2012
MEASUREMENTS AND MAIN RESULTS: The proteins PopB, FpvA, FptA, OprL, and PilQ elicited strong IL-17 secretion in the screen, and purified versions of PopB, FpvA, and OprL stimulated high IL-17 production from immune splenocytes.
Ki-67 grading of nonfunctioning pancreatic neuroendocrine tumors on histologic samples obtained by EUS-guided fine-needle tissue acquisition: a prospective study.
Rindi et al., Roma, Italy. In Gastrointest Endosc, 2012
OBJECTIVE: To prospectively evaluate the feasibility, yield, and clinical impact of EUS-guided fine-needle tissue acquisition (EUS-FNTA) with a large-gauge needle to obtain tissue samples for histologic diagnosis and Ki-67 analysis in patients with suspected NF-PETs.
Inner-membrane transporters for the siderophores pyochelin in Pseudomonas aeruginosa and enantio-pyochelin in Pseudomonas fluorescens display different enantioselectivities.
Reimmann, Lausanne, Switzerland. In Microbiology, 2012
The iron-loaded forms of Pch (ferriPch) and of EPch (ferriEPch) are recognized stereospecifically (i) at the outer membrane by the siderophore receptors FptA in P. aeruginosa and FetA in P. fluorescens and (ii) in the cytoplasm by the two AraC-type regulators PchR, which are activated by their cognate siderophore.
Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.
Halayko et al., Winnipeg, Canada. In Am J Physiol Lung Cell Mol Physiol, 2012
our findings identify Geranylgeranyl transferase 1 as a key regulator of human airway smooth muscle cell viability
Proteomics of Pseudomonas aeruginosa Australian epidemic strain 1 (AES-1) cultured under conditions mimicking the cystic fibrosis lung reveals increased iron acquisition via the siderophore pyochelin.
Cordwell et al., Sydney, Australia. In J Proteome Res, 2012
Proteins associated with biosynthesis of the iron-scavenging siderophore pyochelin (PchDEFGH and FptA) were also present at elevated abundance in AES-1R and at much higher levels than in PAO1, whereas they were reduced in PA14.
A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.
Hughes et al., Novato, United States. In Plos Genet, 2011
These data indicate that mutant huntingtin exerts a pathogenic effect on this pathway that can be corrected at multiple intervention points including RRAS, FNTA/B, PIN1, and PLK1.
Constitutional trisomy 8p11.21-q11.21 mosaicism: a germline alteration predisposing to myeloid leukaemia.
Steinemann et al., Hannover, Germany. In Br J Haematol, 2011
MYST3, IKBKB, UBE2V2, GOLGA7, FNTA and MIR486--a finding with potential implications for the role of somatic trisomy 8 in myeloid malignancies.
The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner.
Giannakakou et al., Atlanta, United States. In J Biol Chem, 2009
FTase, via its tubulin-association, is a critical upstream regulator of HDAC6 activity
Molecular mechanism of ferricsiderophore passage through the outer membrane receptor proteins of Escherichia coli.
van der Helm et al., Johnson City, United States. In Biometals, 2007
The crystal structures of three outer membrane ferricsiderophore receptor proteins FepA, FhuA and FecA from Escherichia coli and two FpvA and FptA from Pseudomonas aeruginosa have recently been solved.
Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells.
Kowluru et al., Detroit, United States. In Diabetes, 2007
Geranylgeranyltransferase inhibitor-2147 (GGTI-2147), an inhibitor of protein prenylation, elicited significant inhibition of glucose-stimulated insulin secretion from INS 832/13 islet cells.
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies.
Gray et al., San Francisco, United States. In Cancer Cell, 2006
Nine of these (FGFR1, IKBKB, ERBB2, PROCC, ADAM9, FNTA, ACACA, PNMT, and NR1D1) are considered druggable.
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.
Beese et al., Durham, United States. In J Mol Biol, 2004
Results suggest that all peptide substrates adopt a common binding mode in the protein farnesyltransferase and geranylgeranyltransferase active site.
Pseudomonas aeruginosa antigens as potential vaccines.
Lam et al., Moscow, Russia. In Fems Microbiol Rev, 1997
Two of these in vivo-expressed proteins are FptA (ferripyochelin receptor protein) and a homologue of an LPS biosynthetic enzyme.
The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling.
Donahoe et al., Boston, United States. In Science, 1996
The alpha subunit of p21(RAS) farnesyltransferase (FNTA), which is also shared by geranylgeranyltransferase, was isolated as a specific cytoplasmic interactor of the transforming growth factor-beta (TGF-beta) and activin type I receptors with the use of the yeast two-hybrid system.
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