Avian dendritic cells: phenotype and ontogeny in lymphoid organs.
Budapest, Hungary. In Dev Comp Immunol, Feb 2016
Bursal secretory dendritic cells (BSDC) are elongated cells which express vimentin intermediate filaments, MHC II molecules, macrophage colony-stimulating factor 1 receptor (CSF1R), and produce 74.3+ secretory granules.
Clinical potential of pacritinib in the treatment of myelofibrosis.
Oxford, United Kingdom. In Ther Adv Hematol, Aug 2015
Pacritinib, a JAK2 and FMS-like tyrosine kinase 3 (FLT3) inhibitor, has shown promising results in early phase trials with limited myelotoxicity and clinical responses that are comparable with those seen with ruxolitinib, even in patients with severe thrombocytopenia.
Therapeutic targeting of macrophages in lupus nephritis.
United States. In Discov Med, Jul 2015
The current literature explores targeting macrophages by several different means, including the CSF-1/CSF-1R signaling axis, the CX3CL1/CX3CR1 signaling axis, the CCL2/CCR2 signaling axis, and Bruton's Tyrosine Kinase (BTK), all of which hold promise as targets for future LN treatments.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Memphis, United States. In N Engl J Med, 2014
Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common.
Osteoclasts: New Insights.
Birmingham, United States. In Bone Res, 2013
M-CSF binds to its receptor c-Fms to activate distinct signaling pathways to stimulate the proliferation and survival of osteoclast precursors and the mature cell.