Avian dendritic cells: phenotype and ontogeny in lymphoid organs.
Budapest, Hungary. In Dev Comp Immunol, Feb 2016
Bursal secretory dendritic cells (BSDC) are elongated cells which express vimentin intermediate filaments, MHC II molecules, macrophage colony-stimulating factor 1 receptor (CSF1R), and produce 74.3+ secretory granules.
Role of endothelin in preeclampsia and hypertension following antiangiogenesis treatment.
Rotterdam, Netherlands. In Curr Opin Nephrol Hypertens, Jan 2016
PURPOSE OF REVIEW: Preeclampsia is a systemic, pregnancy-related disorder featuring hypertension and proteinuria arising from placental overproduction of soluble FMS-like tyrosine kinase-1, resulting in an antiangiogenic state because of the inhibition of the vascular endothelial growth factor (VEGF) family.
Therapeutic targeting of macrophages in lupus nephritis.
United States. In Discov Med, Jul 2015
The current literature explores targeting macrophages by several different means, including the CSF-1/CSF-1R signaling axis, the CX3CL1/CX3CR1 signaling axis, the CCL2/CCR2 signaling axis, and Bruton's Tyrosine Kinase (BTK), all of which hold promise as targets for future LN treatments.
Overexpression of CSF-1R in nasopharyngeal carcinoma.
China. In Rom J Morphol Embryol, 2014
OBJECTIVES: The aim of this study was to compare the expression of CSF-1R in nasopharyngeal carcinoma to nasopharyngitis for assessing the role CSF-1÷CSF-1R in nasopharyngeal carcinoma.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Memphis, United States. In N Engl J Med, 2014
Kinase-activating alterations were identified in 91% of patients with Ph-like ALL; rearrangements involving ABL1, ABL2, CRLF2, CSF1R, EPOR, JAK2, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2 and sequence mutations involving FLT3, IL7R, or SH2B3 were most common.