Identification of GPM6A and GPM6B as potential new human lymphoid leukemia-associated oncogenes.
Montréal, Canada. In Cell Oncol (dordr), 2014
We observed over-expression of a variety of genes, including Arntl2, Bfsp2, Gfra2, Gpm6a, Gpm6b, Nln, Fbln1, Bmp7, Etv5 and Celsr1 and, in addition, provided evidence that Fmn2 and Parm-1 may act as novel oncogenes.
Polarity gene alterations in pure invasive micropapillary carcinomas of the breast.
In Breast Cancer Res, 2013
Whole-exome sequencing combined with RNA sequencing of IMPC allowed us to identify somatic mutations in genes involved in polarity, DNAH9 and FMN2 (8% and 2%, respectively) or ciliogenesis, BBS12 and BBS9 (2% each) or genes coding for endoplasmic reticulum protein, HSP90B1 and SPTLC3 (2% each) and cytoskeleton, UBR4 and PTPN21 (2% each), regardless of the genomic subset.
Symmetry breaking and polarity establishment during mouse oocyte maturation.
Kansas City, United States. In Philos Trans R Soc Lond B Biol Sci, 2012
This feedback loop not only maintains meiotic II spindle position during metaphase II arrest, but also brings about symmetry breaking during meiosis I. Prior to an Arp2/3-dependent phase of fast movement, meiotic I spindle experiences a slow and non-directional first phase of migration driven by a pushing force from Fmn2-mediated actin polymerization.