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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neuromedin U receptor 1

FM3, NMU-R1, NMU1R
Top mentioned proteins: NMU, FM4, Neuropeptide, FasT, ACID
Papers on FM3
Evaluation of lower facial heights as related to different anthropometric measurements in dentate and completely edentulous subjects.
New
Hassan et al., In Quintessence Int, Dec 2015
Base of chin-subnasale measurement (FM1), base of chin-tip of the nose measurement (FM2), Willis' measurement (FM3), glabella-subnasale measurement (FM4), length of the index finger measurement (AM1), and tip of thumb-tip of index finger measurement (AM2) of subjects of G1 and G2 were measured by using a modified caliper while the subjects in G1 closed in centric occlusion, and the subjects of G2 were asked to close the maxillary and mandibular complete dentures in centric relation.
Neuromedin U inhibits food intake partly by inhibiting gastric emptying.
New
Jelsing et al., Hørsholm, Denmark. In Peptides, Jul 2015
Neuromedin U (NMU) is a gut-brain peptide, implicated in energy and glucose homeostasis via the peripherally expressed NMU receptor 1 (NMUR1) and the central NMUR2.
Discovery of potent hexapeptide agonists to human neuromedin u receptor 1 and identification of their serum metabolites.
New
Hayashi et al., Hachiōji, Japan. In Acs Med Chem Lett, Apr 2015
Neuromedin U (NMU) and S (NMS) display various physiological activities, including an anorexigenic effect, and share a common C-terminal heptapeptide-amide sequence that is necessary to activate two NMU receptors (NMUR1 and NMUR2).
Suppression of insulin production and secretion by a decretin hormone.
New
Impact
Kim et al., Stanford, United States. In Cell Metab, Mar 2015
NMUR1 is expressed in islet β cells, and purified NMU suppresses insulin secretion from human islets.
Identification of G Protein-Coupled Receptors (GPCRs) in Primary Cilia and Their Possible Involvement in Body Weight Control.
Furukawa et al., Suita, Japan. In Plos One, 2014
We found that several GPCRs whose ligands are involved in feeding behavior, including prolactin-releasing hormone receptor (PRLHR), neuropeptide FF receptor 1 (NPFFR1), and neuromedin U receptor 1 (NMUR1), localized to the primary cilia.
Identifying a Neuromedin U Receptor 2 Splice Variant and Determining Its Roles in the Regulation of Signaling and Tumorigenesis In Vitro.
Luo et al., Taipei, Taiwan. In Plos One, 2014
Neuromedin U (NMU) activates two G protein-coupled receptors, NMUR1 and NMUR2; this signaling not only controls many physiological responses but also promotes tumorigenesis in diverse tissues.
Application of Isfarzeh seed (Plantago ovate L.) mucilage as a fat mimetic in mayonnaise.
Ranjbar et al., Gorgān, Iran. In J Food Sci Technol, 2014
Fat was partially substituted by mucilage gels (2 and 3 % suspensions) at levels of 30, 40 and 50 % which were referred to as FM2-30 % (2 % gel and 30 % substitution level), FM2-40 %, FM2-50 %, FM3-30 %, FM3-40 %, and FM3-50 % formulations, respectively and the full fat (Ff) mayonnaise with 78 % oil was used as control.
Discovery of selective hexapeptide agonists to human neuromedin U receptors types 1 and 2.
Hayashi et al., Hachiōji, Japan. In J Med Chem, 2014
Neuromedin U (NMU) are bioactive peptides with a common C-terminal heptapeptide sequence (FLFRPRN-amide, 1a) among mammals, which is responsible for receptor activation, namely NMU receptor types 1 (NMUR1) and 2 (NMUR2).
Mediators involved in the hyperthermic action of neuromedin U in rats.
Adamik et al., Szeged, Hungary. In Regul Pept, 2014
Two receptors have been identified: NmU1R is mainly present in peripheral tissues, and Nmu2R in the central nervous system.
Neuromedin U type 1 receptor stimulation of A-type K+ current requires the βγ subunits of Go protein, protein kinase A, and extracellular signal-regulated kinase 1/2 (ERK1/2) in sensory neurons.
GeneRIF
Tao et al., Suzhou, China. In J Biol Chem, 2012
results suggested that NMU increases I(A) via activation of NMUR1 that couples sequentially to the downstream activities of Gbetagamma of the G(o) protein, PKA, and ERK
[The discovery of neuromedin U and its pivotal role in the central regulation of energy homeostasis].
Review
Zięba et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2011
Neuromedin U (NMU) is a structurally highly conserved neuropeptide and has been paired with the G-protein-coupled receptors (GPCRs) NMUR1 and NMUR2, which were formerly classified in the orphan receptor family.
Activation of neuromedin U type 1 receptor inhibits L-type Ca2+ channel currents via phosphatidylinositol 3-kinase-dependent protein kinase C epsilon pathway in mouse hippocampal neurons.
GeneRIF
Tao et al., Suzhou, China. In Cell Signal, 2010
neuromedin-U receptor 1 inhibits L-type HVGCC via activation of NMUR1 and downstream G(betagamma), PI3K, and a novel PKC epsilon signaling pathway.
Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S.
Review
Davenport et al., Cambridge, United Kingdom. In Br J Pharmacol, 2009
Neuromedin U (NMU) has been paired with the G-protein-coupled receptors (GPRs) NMU(1) (formerly designated as the orphan GPR66 or FM-3) and NMU(2) (FM-4 or hTGR-1).
Nmur1-/- mice are not protected from cutaneous inflammation.
GeneRIF
Hedrick et al., United States. In Biochem Biophys Res Commun, 2009
These data argues against a major role for Nmur1 in mediating the reported inflammatory functions of NmU.
Neuromedin S: discovery and functions.
Review
Kangawa et al., Suita, Japan. In Results Probl Cell Differ, 2007
Neuromedin S, a novel neuropeptide of 36 amino acids, was isolated from rat brain as an endogenous ligand for the orphan G protein-coupled receptors FM-3/GPR66 and FM-4/TGR-1, identified to date as type-1 and type-2 neuromedin U (NMU) receptors, respectively.
Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses.
GeneRIF
Murphy et al., United States. In Pain, 2007
the pro-nociceptive effects of neuromedin U in mice appear to be mediated through NMUR2, not NMUR1
Species-dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice.
GeneRIF
Shankley et al., San Diego, United States. In Br J Pharmacol, 2006
A study evaluating smooth muscle contraction in NMU1 receptor knockout mouse was used to determine which receptor subtype mediates the contractile responses generated by neuromedin in the mouse.[NMU1 receptor]
Identification of receptors for neuromedin U and its role in feeding.
Impact
Liu et al., Rahway, United States. In Nature, 2000
Here we show that the previously described orphan G-protein-coupled receptor FM-3 (ref.
Growth hormone releasing substances: types and their receptors.
Review
Howard et al., Houston, United States. In Horm Res, 1998
Three FMs GPR38, GPR39 and FM3 were isolated from human genomic libraries.
The immunogenic properties of human melanomas and melanoma-associated antigens recognized by cytotoxic T lymphocytes.
Review
Kirkin et al., Copenhagen, Denmark. In Bratisl Lek Listy, 1998
So far, only two such melanoma cell lines, FM3 and FM57 have been identified in this panel.
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