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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Feline leukemia virus subgroup C cellular receptor 1

FLVCR, FLVCR1, hFLVCR, feline leukemia virus subgroup C receptor, feline leukemia virus subgroup C receptor FLVCR1
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: CAN, ACID, Transferrin, HAD, Hepcidin
Papers on FLVCR
Coordinate expression of heme and globin is essential for effective erythropoiesis.
Abkowitz et al., In J Clin Invest, Jan 2016
Mice lacking the heme exporter FLVCR1 have a severe macrocytic anemia; however, the mechanisms that underlie erythropoiesis dysfunction in these animals are unclear.
Alteration of heme metabolism in a cellular model of Diamond-Blackfan anemia.
Chiabrando et al., Torino, Italy. In Eur J Haematol, Jul 2015
Alternative spliced isoforms of FLVCR1 (feline leukemia virus subgroup C receptor 1) transcript coding for non-functional proteins have been reported in some DBA patients.
Heme exporter FLVCR is required for T cell development and peripheral survival.
Abkowitz et al., Seattle, United States. In J Immunol, Mar 2015
The feline leukemia virus subgroup C receptor (FLVCR) is a 12-transmembrane domain surface protein that exports heme from cells, and it was shown to be required for erythroid development.
Autosomal recessive posterior column ataxia with retinitis pigmentosa caused by novel mutations in the FLVCR1 gene.
Shinawi et al., Houston, United States. In Int J Neurosci, 2015
Recently, mutations in the FLVCR1 gene were described in four families with this condition.
Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status.
O'Brien et al., Rochester, United States. In Reproduction, 2014
LDL receptor-related protein 1 (LRP1) is a transmembrane receptor highly expressed in human placenta.
Quantitative expression of candidate genes affecting eggshell color.
Ning et al., Beijing, China. In Anim Sci J, 2014
Breast cancer resistance protein (BCRP), feline leukemia virus receptor (FLVCR), and heme-responsive gene-1 (HRG1) serve as primary transporters for both protoporphyrinogen and heme.
Comparison of protoporphyrin IX content and related gene expression in the tissues of chickens laying brown-shelled eggs.
Yang et al., Beijing, China. In Poult Sci, 2013
The results showed that expression of aminolevulinic acid synthase-1 (ALAS1) was higher in the liver of hens laying darker brown shelled eggs, whereas in the shell gland the expression levels of ALAS1, coproporphyrinogen oxidase (CPOX), ATP-binding cassette family members ABCB7 and ABCG2, and receptor for feline leukemia virus, subgroup C (FLVCR) were significantly higher in the hens laying darker brown shelled eggs.
FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function.
Abkowitz et al., Seattle, United States. In Blood, 2013
One mechanism is through active heme export by the group C feline leukemia virus receptor (FLVCR).
Identification and expression of iron regulators in human synovium: evidence for upregulation in haemophilic arthropathy compared to rheumatoid arthritis, osteoarthritis, and healthy controls.
Lafeber et al., Utrecht, Netherlands. In Haemophilia, 2013
The aim of this study was to investigate the synovial presence of the iron regulator proteins ferroportin (FPN), hepcidin, haemoglobin scavenger receptor CD163 (CD163), feline leukaemia virus subgroup C (FLVCR), and heme carrier protein 1 (HCP-1).
Heme and FLVCR-related transporter families SLC48 and SLC49.
Quigley et al., Chicago, United States. In Mol Aspects Med, 2013
Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis.
Mutations of FLVCR1 in posterior column ataxia and retinitis pigmentosa result in the loss of heme export activity.
Kishi et al., Kurashiki, Japan. In Blood Cells Mol Dis, 2012
FLVCR1 mutants failed to fold properly in the ER, were rapidly degraded in the lysosomes, and therefore, could not export heme out of cells. Thus, accumulation of heme in FLVCR1-mutant cells could cause cellular toxicity.
Genetic mapping and exome sequencing identify variants associated with five novel diseases.
Strauss et al., United States. In Plos One, 2011
Study identified sequence variants in the known disease-causing genes SLC6A3 and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1, SNIP1, CRADD, and HARS.
Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis.
Ganapathy et al., Augusta, United States. In Invest Ophthalmol Vis Sci, 2011
Hemochromatosis is associated not only with excessive accumulation of free iron in the retina and retinal pigment epithelium but also with excessive accumulation of heme.
Placental expression of the heme transporter, feline leukemia virus subgroup C receptor, is related to maternal iron status in pregnant adolescents.
O'Brien et al., Ithaca, United States. In J Nutr, 2011
relative protein expression of 2 heme transporters, Feline Leukemia Virus, Subgroup C, Receptor 1 (FLVCR1) and Breast Cancer Resistance Protein, was assessed in placental tissue in relation to maternal/neonatal iron status and placental iron concentration
Posterior column ataxia with retinitis pigmentosa in a Japanese family with a novel mutation in FLVCR1.
Tsuji et al., Tokyo, Japan. In Neurogenetics, 2011
Posterior column ataxia with retinitis pigmentosa is caused by mutations in FLVCR1.
Control of intracellular heme levels: heme transporters and heme oxygenases.
Quigley et al., Chicago, United States. In Biochim Biophys Acta, 2011
Here we review aspects of heme metabolism and discuss our current understanding of heme transporters, with emphasis on the function of the cell-surface heme exporter, FLVCR.
A heme export protein is required for red blood cell differentiation and iron homeostasis.
Abkowitz et al., Seattle, United States. In Science, 2008
data show that FLVCR exports heme & is required by erythroid progenitors to complete terminal differentiation; data show that FLVCR functions in macrophage heme-iron recycling and that systemic iron balance involves heme-iron trafficking via FLVCR
The role of transporters in cellular heme and porphyrin homeostasis.
Schuetz et al., Memphis, United States. In Pharmacol Ther, 2007
In this review, we focus on the roles of the recently identified heme/porphyrin transport proteins heme carrier protein 1 (HCP1), FLVCR, Abcg2 and Abcb6 and discuss how these transporters contribute to intracellular heme and porphyrin homeostasis.
Recent advances in mammalian haem transport.
McKie et al., London, United Kingdom. In Trends Biochem Sci, 2006
FLVCR protects developing erythroid cells from haem toxicity during the early stages of differentiation, and ABCG2 averts protoporphyrin accumulation (particularly under hypoxic conditions).
Identification of a human heme exporter that is essential for erythropoiesis.
Abkowitz et al., Seattle, United States. In Cell, 2004
FLVCR, a member of the major facilitator superfamily of transporter proteins, is the cell surface receptor for feline leukemia virus, subgroup C. Retroviral interference with FLVCR display results in a loss of erythroid progenitors (colony-forming units-erythroid, CFU-E) and severe anemia in cats.
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