Heme and FLVCR-related transporter families SLC48 and SLC49.
Chicago, United States. In Mol Aspects Med, 2013
Feline leukemia virus subgroup C receptor (FLVCR1), a member of the SLC49 family of four paralogous genes, is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis.
The role of transporters in cellular heme and porphyrin homeostasis.
Memphis, United States. In Pharmacol Ther, 2007
In this review, we focus on the roles of the recently identified heme/porphyrin transport proteins heme carrier protein 1 (HCP1), FLVCR, Abcg2 and Abcb6 and discuss how these transporters contribute to intracellular heme and porphyrin homeostasis.
Recent advances in mammalian haem transport.
London, United Kingdom. In Trends Biochem Sci, 2006
FLVCR protects developing erythroid cells from haem toxicity during the early stages of differentiation, and ABCG2 averts protoporphyrin accumulation (particularly under hypoxic conditions).
Identification of a human heme exporter that is essential for erythropoiesis.
Seattle, United States. In Cell, 2004
FLVCR, a member of the major facilitator superfamily of transporter proteins, is the cell surface receptor for feline leukemia virus, subgroup C. Retroviral interference with FLVCR display results in a loss of erythroid progenitors (colony-forming units-erythroid, CFU-E) and severe anemia in cats.