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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Zinc finger, MYND-type containing 10

Flu, Ubc13, BLU
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, Ubiquitin
Papers using Flu antibodies
Fluoxetine potentiates GABAergic IPSCs in rat hippocampal neurons
Whelan M. et al., In Frontiers in Neuroengineering, 2007
... R-(–)-Fluoxetine hydrochloride (FLU, Sigma Aldrich – F1678), CAS: 114247-09-5 ...
Papers on Flu
Palladium-benzodiazepine derivatives as promising metallodrugs for the development of antiepileptic therapies.
Meneghetti et al., Maceió, Brazil. In J Inorg Biochem, Feb 2016
The possible mechanism of action of the DZP-palladium(II) complexes was also confirmed with the use of flumazenil (FLU), a GABAA-benzodiazepine receptor complex site antagonist.
Flubendazole induces mitotic catastrophe and senescence in colon cancer cells in vitro.
Skálová et al., Hradec Králové, Czech Republic. In J Pharm Pharmacol, Feb 2016
OBJECTIVES: Flubendazole (FLU), a member of benzimidazole family of anthelmintic drugs, is able to inhibit proliferation of various cancer cells.
Vaccine induced antibody responses prevent the induction of Interferon type I responses upon a homotypic live virus challenge.
Alsharifi et al., Adelaide, Australia. In Scand J Immunol, Jan 2016
Mice were vaccinated with gamma-irradiated influenza A virus (γ-FLU) and challenged three weeks later with live virus.
Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.
Mailand et al., Copenhagen, Denmark. In Nature, Dec 2015
This depends on the sequential actions of the E3 ubiquitin ligases RNF8 and RNF168 (refs 1-6), and UBC13 (also known as UBE2N), an E2 ubiquitin-conjugating enzyme that specifically generates K63-linked ubiquitin chains.
[Effect of Acupuncture Intervention on Expression of NF-κB Signal Pathway in the Hippocampus of Chronic Stress-induced Depression Rats].
Tu et al., In Zhen Ci Yan Jiu, Oct 2015
METHODS: Thirty-six male Sprague-Dawley rats were randomly divided into four groups: control, model, acupuncture, and medication (fluoxetine, Flu) (n = 9 rats in each group).
Molecular Cloning and Functional Characterization of Two Brachypodium distachyon UBC13 Genes Whose Products Promote K63-Linked Polyubiquitination.
Xiao et al., Beijing, China. In Front Plant Sci, 2014
Here, we report the identification and functional characterization of two B. distachyon UBC13 genes.
Conformation and Linkage Studies of Specific Oligosaccharides Related to H1N1, H5N1, and Human Flu for Developing the Second Tamiflu.
Yoo, Kwangju, South Korea. In Biomol Ther (seoul), 2014
It is newly suggested that flu infection and transmission to humans require high affinity binding to the extended conformation with long length sialyl(α2-6)galactose containing oligosaccharides.
Viral M2 ion channel protein: a promising target for anti-influenza drug discovery.
Pratheepa et al., Porto, Portugal. In Mini Rev Med Chem, 2013
Influenza virus is an important RNA virus causing pandemics (Spanish Flu (1918), Asian Flu (1957), Hong Kong Flu (1968) and Swine Flu (2009)) over the last decades.
Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes.
Hasty et al., San Antonio, United States. In Nature, 2013
EF-PRR bypasses DNA incongruities that impede replication by ubiquitinating PCNA (proliferating cell nuclear antigen) using the RAD6-RAD18 and UBC13-MMS2-RAD5 ubiquitin ligase complexes.
Veterinary vaccines from transgenic plants: highlights of two decades of research and a promising example.
Conrad et al., Germany. In Curr Pharm Des, 2012
This up-and-coming tool was applied for the development of effective production and purification strategies for antigens against Avian Flu, a very important animal disease with a strong economic impact.
Molecular basis of Lys-63-linked polyubiquitination inhibition by the interaction between human deubiquitinating enzyme OTUB1 and ubiquitin-conjugating enzyme UBC13.
Fukai et al., Tokyo, Japan. In J Biol Chem, 2012
the crystal structure of human OTUB1 in complex with human UBC13 and MMS2
Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation.
Glover et al., Edmonton, Canada. In J Biol Chem, 2012
Data show RING finger (RNF) E3 ubiquitin ligase RNF8 dimerizes and binds to E2 ubiquitin-conjugating complex Ubc13/Mms2 with formation of Lys-63 ubiquitin chains, whereas the RNF168 RING domain is a monomer and does not catalyze Lys-6 ubiquitylation.
Tumor suppressor BLU enhances pro-apoptotic activity of sMEK1 through physical interaction.
Rho et al., South Korea. In Cell Signal, 2012
The N-terminal of BLU was observed to interact with the C-terminal of SMEK1, a regulatory subunit of protein phosphatase 4. Furthermore, we determined the binding domains that are required for interaction between BLU and sMEK1. The N-terminal of BLU was observed to interact with the C-terminal of sMEK1.
Ubc13 and COOH terminus of Hsp70-interacting protein (CHIP) are required for growth hormone receptor endocytosis.
Strous et al., Utrecht, Netherlands. In J Biol Chem, 2012
Data show that growth hormone receptor (GHR) endocytosis requires both ubiquitin-conjugating enzyme Ubc13 and the ubiquitin ligase COOH terminus of Hsp70 interacting protein (CHIP).
Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells.
Sun et al., Houston, United States. In Nat Immunol, 2012
Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells.
The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response.
Sasakawa et al., Tokyo, Japan. In Nature, 2012
OspI is a glutamine deamidase that selectively deamidates the glutamine residue at position 100 in UBC13 to a glutamic acid residue.
The mechanism of OTUB1-mediated inhibition of ubiquitination.
Wolberger et al., Baltimore, United States. In Nature, 2012
UBC13 (also known as UBE2N) is a ubiquitin-conjugating enzyme (E2) that heterodimerizes with UEV1A (also known as UBE2V1) and synthesizes K63-linked polyubiquitin (K63Ub) chains at DSB sites in concert with the ubiquitin ligase (E3), RNF168 (ref.
TRIM5 is an innate immune sensor for the retrovirus capsid lattice.
Luban et al., Genève, Switzerland. In Nature, 2011
Acting with the heterodimeric, ubiquitin-conjugating enzyme UBC13-UEV1A (also known as UBE2N-UBE2V1), TRIM5 catalyses the synthesis of unattached K63-linked ubiquitin chains that activate the TAK1 (also known as MAP3K7) kinase complex and stimulate AP-1 and NFκB signalling.
Kurinczuk et al., Southampton, United Kingdom. In Unknown Journal, 0001
DESIGN: A new UKOSS cohort study was designed, based on the 2009–10 study, and following consultation with the Pandemic Flu Planning Group at the Royal College of Obstetricians and Gynaecologists and the UKOSS Steering Committee, to identify potential previously unanswered questions.
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