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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Fms-related tyrosine kinase 3 ligand

Flt3 ligand, Flt3L
Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011] (from NCBI)
Top mentioned proteins: FLT3, CsF, CAN, FMS, SCF
Papers on Flt3 ligand
A Matter of Perspective: Moving from a Pre-omic to a Systems-Biology Vantage of Monocyte-Derived Cell Function and Nomenclature.
New
Impact
Malissen et al., Gent, Belgium. In Immunity, Feb 2016
Given the complexity of the cells generated in GM-CSF BM cultures, we suggested that recently described Flt3L-based culture systems are better suited for the study of conventional DCs (cDCs) in vitro and the manufacture of cDC-based vaccines.
Delayed application of the haematopoietic growth factors G-CSF/SCF and FL reduces neonatal excitotoxic brain injury.
New
Griesmaier et al., Innsbruck, Austria. In Brain Res, Feb 2016
The effect of haematopoietic growth factors, such as granulocyte colony-stimulating factor (G-CSF), stem cell factor (SCF) and flt-3 ligand (FL) on neonatal brain injury is controversially discussed.
The combination of FLT3 and DNA methyltransferase inhibition is synergistically cytotoxic to FLT3/ITD acute myeloid leukemia cells.
New
Konig et al., Indianapolis, United States. In Leukemia, Jan 2016
DNA methyltransferase (DNMT) inhibitors such as decitabine (DEC) and 5-azacitidine (AZA) demonstrated clinical benefit in AML, are well tolerated, and are associated with minimal increases in FLT3 ligand, which can represent a potential resistance mechanism to FLT3 inhibitors.
3,3'-Diindolylmethane Inhibits Flt3L/GM-CSF-induced-bone Marrow-derived CD103(+) Dendritic Cell Differentiation Regulating Phosphorylation of STAT3 and STAT5.
New
Jeong et al., Ch'angwŏn, South Korea. In Immune Netw, Dec 2015
In this study, we found that AhR ligand 3,3'-diindolylmethane (DIM) inhibited the development of CD103(+) DCs from mouse bone marrow cells stimulated with Flt3L and GM-CSF.
Changes in plasma biomarkers following treatment with cabozantinib in metastatic castration-resistant prostate cancer: a post hoc analysis of an extension cohort of a phase II trial.
New
Joshua et al., Israel. In J Transl Med, Dec 2015
Plasma concentrations of VEGFA, FLT3L, c-MET, AXL, Gas6A, bone-specific alkaline phosphatase, interleukin-8 and the hypoxia markers CA9 and clusterin significantly increased during treatment with cabozantinib irrespective of response.
PI3-Kinase-γ Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development.
New
Impact
Kopf et al., Zürich, Switzerland. In Immunity, Nov 2015
Here we show that the Ras-PI3Kγ-Akt-mTOR signaling axis acted downstream of FLT3L signaling and was required for development of lung CD103(+) DCs and, to a smaller extent, for lung CD11b(+) DCs, but not related DC populations in other non-lymphoid organs.
Haematopoietic and immune defects associated with GATA2 mutation.
Review
New
Bigley et al., Newcastle upon Tyne, United Kingdom. In Br J Haematol, Apr 2015
Although often healthy in childhood, carriers of defective GATA2 alleles develop progressive loss of mononuclear cells (dendritic cells, monocytes, B and Natural Killer lymphocytes), elevated FLT3 ligand, and a 90% risk of clinical complications, including progression to myelodysplastic syndrome (MDS) by 60 years of age.
The Roles of IL-2, IL-7, and IL15 Ligands in B Cells Development from Cord Blood Mononuclear Cells.
Nozad Charoudeh et al., In Iran J Ped Hematol Oncol, 2014
It has been shown that B cells produced successfully in the presence of stem cell factor (SCF) and Flt3 ligand (Flt3L).
Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.
Impact
Krummel et al., San Francisco, United States. In Cancer Cell, 2014
These are uniquely dependent on IRF8, Zbtb46, and Batf3 transcription factors and are generated by GM-CSF and FLT3L cytokines.
Dendritic cell-based cancer immunotherapy: the stagnant approach and a theoretical solution.
Review
Subbotin, Madison, United States. In Drug Discov Today, 2014
I hypothesize that stable tumor transfection with fetal liver tyrosine kinase 3 ligand (Flt3-L) and granulocyte-macrophage colony-stimulating factor (GM-CSF) DNAs will induce homing, propagation and maturation of intratumoral DC.
Future considerations for dendritic cell immunotherapy against chronic viral infections.
Review
van Drunen Littel-van den Hurk et al., Saskatoon, Canada. In Expert Rev Clin Immunol, 2014
In vivo expansion and mobilization of DCs with Flt3L in combination with antigen and/or adjuvant targeting to critical DC receptors may be a more effective approach to control viral replication in chronically infected HIV, HBV and/or HCV patients than current DC immunotherapy approaches.
Fms-like tyrosine kinase 3 ligand-dependent dendritic cells in autoimmune inflammation.
Review
Lebre et al., Amsterdam, Netherlands. In Autoimmun Rev, 2014
Initial in vitro studies of cytokines in DC development revealed distinct and important roles for the receptor tyrosine kinases, granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF, also called CSF1) and fms-like tyrosine kinase 3 ligand (Flt3L) in the generation of DCs.
Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection.
Impact
Nussenzweig et al., New York City, United States. In Nat Med, 2013
Here we describe an innate sensing pathway triggered by Plasmodium infection that regulates dendritic cell homeostasis and adaptive immunity through Flt3 ligand (Flt3l) release.
Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen.
Impact
Lambrecht et al., Gent, Belgium. In Immunity, 2013
Studies in Flt3l(-/-) mice, lacking all cDCs, revealed that moDCs were also sufficient to induce Th2 cell-mediated immunity but only when high-dose HDM was given.
Gene therapy for brain tumors: basic developments and clinical implementation.
Review
Castro et al., Ann Arbor, United States. In Neurosci Lett, 2012
We also review the combined conditional cytotoxic immune stimulatory therapy that our lab has developed which is dependent on the adenovirus mediated expression of the conditional cytotoxic gene, Herpes Simplex Type 1 Thymidine Kinase (TK) and the powerful DC growth factor Fms-like tyrosine kinase 3 ligand (Flt3L).
Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis.
GeneRIF
Katayama et al., Tsu, Japan. In Br J Haematol, 2012
Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis.
Blockade of prostaglandin E2 signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells.
GeneRIF
Pelus et al., Indianapolis, United States. In Blood, 2012
A novel dendritic cell(DC) progenitor regulatory pathway in which PGE(2) signaling through EP1/EP3 receptors regulates Flt3 expression and downstream STAT3 activation and survivin expression, required for optimal progenitor survival and differentiation.
Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.
GeneRIF
Jacobsen et al., Lund, Sweden. In Blood, 2011
The mouse Flt3(ITD/ITD) myeloid phenotype is FLT3 ligand-independent.
Further activation of FLT3 mutants by FLT3 ligand.
GeneRIF
Small et al., Baltimore, United States. In Oncogene, 2011
FLT3 ligand(FL) leads to further activation of FLT3 mutants and is especially important in light of recent findings of elevated FL levels in acute myeloid leukemia patients in response to chemotherapy.
Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain.
GeneRIF
Liu et al., New York City, United States. In J Exp Med, 2011
Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain.
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