Haematopoietic and immune defects associated with GATA2 mutation.
Newcastle upon Tyne, United Kingdom. In Br J Haematol, Apr 2015
Although often healthy in childhood, carriers of defective GATA2 alleles develop progressive loss of mononuclear cells (dendritic cells, monocytes, B and Natural Killer lymphocytes), elevated FLT3 ligand, and a 90% risk of clinical complications, including progression to myelodysplastic syndrome (MDS) by 60 years of age.
Fms-like tyrosine kinase 3 ligand-dependent dendritic cells in autoimmune inflammation.
Amsterdam, Netherlands. In Autoimmun Rev, 2014
Initial in vitro studies of cytokines in DC development revealed distinct and important roles for the receptor tyrosine kinases, granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF, also called CSF1) and fms-like tyrosine kinase 3 ligand (Flt3L) in the generation of DCs.
Gene therapy for brain tumors: basic developments and clinical implementation.
Ann Arbor, United States. In Neurosci Lett, 2012
We also review the combined conditional cytotoxic immune stimulatory therapy that our lab has developed which is dependent on the adenovirus mediated expression of the conditional cytotoxic gene, Herpes Simplex Type 1 Thymidine Kinase (TK) and the powerful DC growth factor Fms-like tyrosine kinase 3 ligand (Flt3L).
Further activation of FLT3 mutants by FLT3 ligand.
Baltimore, United States. In Oncogene, 2011
FLT3 ligand(FL) leads to further activation of FLT3 mutants and is especially important in light of recent findings of elevated FL levels in acute myeloid leukemia patients in response to chemotherapy.