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Fibronectin leucine rich transmembrane protein 1

FLRT1
This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: fibronectin, FGFR1, V1a, Src, CAN
Papers on FLRT1
Critical role of FLRT1 phosphorylation in the interdependent regulation of FLRT1 function and FGF receptor signalling.
GeneRIF
Heath et al., Nottingham, United Kingdom. In Plos One, 2009
the phosphorylation state of FLRT1, which is itself FGFR1 dependent, may play a critical role in the potentiation of FGFR1 signalling and may also depend on a SFK-dependent phosphorylation mechanism acting via the FGFR
Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3.
Robertson et al., Oxford, United Kingdom. In Dev Biol, 2008
The present study describes the onset and pattern of FLRT1-3 expression in the early mouse embryo.
Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development.
GeneRIF
Rigby et al., London, United Kingdom. In Dev Biol, 2006
FLRT1 is expressed at brain compartmental boundaries in embryo
Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins.
Kunkel et al., Boston, United States. In Genomics, 2000
FLRT1, FLRT2, and FLRT3 comprise a novel gene family isolated in a screen for extracellular matrix proteins expressed in muscle.
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